CRISIS Coronavirus Patent number: 10130701

beDplorable

beDplorable

Senior Member
With the current Coronavirus crisis ongoing, I thought it might be interesting to know where it originated. Note that it was designed to be used in a vaccine.

Coronavirus
Patent number: 10130701
Abstract: The present invention provides a live, attenuated coronavirus comprising a variant replicase gene encoding polyproteins comprising a mutation in one or more of non-structural protein(s) (nsp)-10, nsp-14, nsp-15 or nsp-16. The coronavirus may be used as a vaccine for treating and/or preventing a disease, such as infectious bronchitis, in a subject.
Type: Grant
Filed: July 23, 2015
Date of Patent: November 20, 2018
Assignee: THE PIRBRIGHT INSTITUTE
Inventors: Erica Bickerton, Sarah Keep, Paul Britton

Link to other patents of THE PIRBRIGHT INSTITUTE

Patents Assigned to The Pirbright Institute - Justia Patents Search

Justia - Patents - Patents and Patent Application Resources
patents.justia.com patents.justia.com

Link to the actual patent application (long and well above my knowledge level)

US Patent for Coronavirus Patent (Patent # 10,130,701 issued November 20, 2018) - Justia Patents Search

The present invention provides a live, attenuated coronavirus comprising a variant replicase gene encoding polyproteins comprising a mutation in one or more of non-structural protein(s) (nsp)-10, nsp-14, nsp-15 or nsp-16. The coronavirus may be used as a vaccine for treating and/or preventing a...
patents.justia.com patents.justia.com
 
beDplorable

beDplorable

Senior Member
summerthyme said:
Er... there are MANY different coronaviruses. Are we sure this is the Wuhan strain?
Click to expand...

That is a good question. Upon further investigation I see this.

[B]Eric Strong[/B]‏ @[B]DrEricStrong[/B] 6h6 hours ago
More
Replying to @[B]Jordan_Sather_[/B]
1. Diseases are not "fads". 2. Coronaviruses are a family of viruses. There are 7 known to infect humans. Others found only in animals. 3. The Wuhan virus appears to be a betacoronavirus, while the patent is for a gammacoronavirus (i.e. they aren't the same!)

My original information was from
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so maybe the original source is up for debate?
 
beDplorable

beDplorable

Senior Member
apparently they working a vaccine for it as we speak though:

amp.cnn.com

Vaccine for new Chinese coronavirus in the works

The National Institutes of Health is working on a vaccine against the new virus that has infected hundreds and killed four in Asia.
amp.cnn.com amp.cnn.com

Vaccine for new Chinese coronavirus in the works
By Elizabeth Cohen, CNN Senior Medical Correspondent
Updated 10:59 PM EST, Mon January 20, 2020

(CNN)The National Institutes of Health is working on a vaccine against the new virus that has infected hundreds and killed four in Asia.

"The NIH is in the process of taking the first steps towards the development of a vaccine," said Dr. Anthony Fauci, director of the National Institutes of Allergy and Infectious Diseases.

Coronavirus explained: What you need to know
Fauci said it would take a few months until the first phase of the clinical trials get underway and more than a year until a vaccine might be available.

The latest

The virus, which was first reported at the end of December, has infected more than 200 people, according to a Chinese government-appointed expert. The bulk of the cases have been in China, but there have been four cases in Thailand, South Korea and Japan.

The virus originated in animals and can be spread from person to person. While most of the patients visited an animal and seafood market in Wuhan, a city about 700 miles south of Beijing, some did not.

This new virus is a coronavirus, which is the same family as the virus that causes SARS, or Severe Acute Respiratory Syndrome, which was first reported in Asia in 2003 and killed more than 700 people. Middle East Respiratory Syndrome, or MERS, which has killed more than 800 people since 2012, is also caused by a coronavirus.

Working on a vaccine

A team of scientists in Texas, New York and China are also at work on a vaccine, according to Dr. Peter Hotez, a vaccine scientist at Baylor College of Medicine in Houston.

China's coronavirus cases likely grossly underestimated, study says
"The lesson we've learned is coronavirus infections are serious and one of the newest and biggest global health threats," Hotez said.

He added that it's less challenging to develop a vaccine for coronaviruses than for other viruses such as HIV or influenza.

"Every virus has its challenges, but coronaviruses can be a relatively straightforward vaccine target," Hotez said.

If a vaccine is developed, he said, health care workers might be among the first to receive it because they're exposed to infected patients.
A second person has died from a new SARS-like virus in China
It is "remarkable" that scientists are able to start developing a vaccine for a virus that was identified less than a month ago, he said.

He credited Chinese researchers, who quickly sequenced and published the virus's genome.

"With SARS, it took almost a year to be able to identify and map the full genetic code," he said. "Now we're doing this in just a few weeks."

'An evolving situation'

Fauci emphasized there are still many questions about this new virus.

"This is an evolving situation, and it's tough to predict ultimately where it will go," he said. "But we have to take it very seriously."

A few things are clear. One, the virus jumped from animals to humans, just like SARS did nearly two decades ago.

He added it's unclear whether just one type of animal is transmitting the virus to humans, or more than one type.

He also said while it's clear this new virus can be spread from person to person, it's unclear how easily that spread can happen.

"Is it a continual spread? Is it sustained? We're not quite sure yet," he said.

Michael Osterholm, director of the Center for Infectious Disease Research and Policy at the University of Minnesota, agreed there are many questions.

"This is one of those inflection moments in outbreak history where we have enough information to be very concerned, but not enough information to say this is going to be an international crisis," he said.
 
S

summerthyme

Administrator
_______________
Yeah, I'd say so. Clickbait headline and misinformation.

Not picking on you... any time a story like this breaks, the nutcases and profiteers come out of the woodwork. Discernment becomes vital.

Summerthyme
 
Reasonable Rascal

Reasonable Rascal

Veteran Member
alchemike said:
From 2012...

www.alarabiya.net

WHO on alert as new Mideast coronavirus kills two Saudis

<p>An outbreak of a virus as fatal to humans as the severe acute respiratory syndrome (SARS) is being observed by the World Health Organization (WHO) as two Saudis have already died of infection. <br/><br/>“As ...</br/></br/></p>
www.alarabiya.net www.alarabiya.net
Click to expand...

The story is from 2012. I believe those were index cases of the MERS-causing coronavirus, which has a case fatality rate in excess of 30% over the years. Fortunately we do not seem to be looking at that with the new coronavirus. That, or it is a slow killer.

www.who.int

Middle East respiratory syndrome coronavirus (MERS-CoV)

Middle East respiratory syndrome coronavirus (MERS-CoV)
www.who.int www.who.int

RR
 
vector7

vector7

Dot Collector
beDplorable said:
Coronavirus
Patent number: 10130701
Abstract: The present invention provides a live, attenuated coronavirus comprising a variant replicase gene encoding polyproteins comprising a mutation in one or more of non-structural protein(s) (nsp)-10, nsp-14, nsp-15 or nsp-16. The coronavirus may be used as a vaccine for treating and/or preventing a disease, such as infectious bronchitis, in a subject.
Type: Grant
Filed: July 23, 2015
Date of Patent: November 20, 2018
Assignee: THE PIRBRIGHT INSTITUTE
Inventors: Erica Bickerton, Sarah Keep, Paul Britton

Link to other patents of THE PIRBRIGHT INSTITUTE

Patents Assigned to The Pirbright Institute - Justia Patents Search

Justia - Patents - Patents and Patent Application Resources
patents.justia.com patents.justia.com

Link to the actual patent application (long and well above my knowledge level)

US Patent for Coronavirus Patent (Patent # 10,130,701 issued November 20, 2018) - Justia Patents Search

The present invention provides a live, attenuated coronavirus comprising a variant replicase gene encoding polyproteins comprising a mutation in one or more of non-structural protein(s) (nsp)-10, nsp-14, nsp-15 or nsp-16. The coronavirus may be used as a vaccine for treating and/or preventing a...
patents.justia.com patents.justia.com
Click to expand...

Hmmm...
 
N

night driver

ESFP adrift in INTJ sea
Probably developed as a gene-splicing vaccine for (As mentioned in the OP) pneumonia or bronchitis. We've been working on several different viri to vax against a number of SERIOUS diseases.
 
Shadow

Shadow

Swift, Silent,...Sleepy
If they had the vaccine for this corona virus and then turned the virus loose they can now discover the vaccine and charge whatever the market will bear.

Maybe the communists are discovering virulent capitalism.

Grist for the conspiracy mill.

Shadow
 
N

night driver

ESFP adrift in INTJ sea
Shadow said:
If they had the vaccine for this corona virus and then turned the virus loose they can now discover the vaccine and charge whatever the market will bear.

Maybe the communists are discovering virulent capitalism.

Grist for the conspiracy mill.

Shadow
Click to expand...
Read carefully. The coronavirus they have the patent for is a vax for OTHER DISEASES and is a (likely) gene-splicing vax virus.

NOT the one out in the wild which could be as innocent as a coronavirus that got into a pig and the pig did what pigs DO.
 
Reasonable Rascal

Reasonable Rascal

Veteran Member
Didn't take long for the conspiratorial-minded to come up with this one. We've both seen and heard of this before, and so far there haven't been any fortunes made off of these get-stuck-or-die vaccines that miraculously appear right after yet another doomsday outbreak.

RR
 
Shadow

Shadow

Swift, Silent,...Sleepy
On the other hand, If this did originate in wildlife, all of this locking down of cities is futile. The wildlife is not locked down. They have not determined which wildlife it originated in. And they may not know for a long time where that particular first animal came from. The resevoir of disease from those animals could be transported to many other smaller population areas without the medical reporting of larger cities.

If it originated in a BL4 lab in Wuhan, got out (never mind how) and is transmissible to animals, well... you get the point!

Shadow
 
O

Old Gray Mare

TB Fanatic
It could have a source endemic in nature that jumped to humans. It may have mutate since jumping species so now it can go Human to Human.

I haven't read any suggestions of asymptomatic carriers? Like a Typhoid Mary for the coronavirus?
 
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