CORONA Key Ingredient in Pfizer and Moderna COVID Shots Aids Cancer Development, New Study Shows

TFergeson

Non Solum Simul Stare
Chalk another one up to TB. We've been talking about vax induced AIDS and vax induced turbo cancers for over a year now.

Key Ingredient in Pfizer and Moderna COVID Shots Aids Cancer Development, New Study Shows​

Commentary
The role that a key ingredient in the COVID-19 mRNA vaccine plays in cancer development has been analyzed in a comprehensive review newly published in a peer-reviewed scientific journal. The conclusion: The specific form of this ingredient, pseudouridine, that Pfizer and Moderna use to make their vaccines aids cancer development.

N1-methyl-pseudouridine (I will call it pseudoU in this article) is a critical component of the mRNA vaccine. Pfizer and Moderna chemically introduce pseudoU into their vaccines to make the mRNA molecules last longer in the human body (escaping degradation by enzymes), and to avoid suppression by the innate immune system, the body’s first line of defense against foreign invaders.


The study, titled “Review: N1-methyl-pseudouridine: Friend or foe of cancer?” is authored by five scientists from Mexico, UK, Canada, United States, and Saudi Arabia and was published in the May 2024 issue of International Journal of Biological Macromolecules.

PseudoU Aids Cancer Development​

Messenger RNA is a single-stranded molecule made up of four types of nucleotides: A, C, G, and U. In their vaccines, Pfizer and Moderna replace all the “U” nucleotides with pseudoU, a chemically modified version. The invention was praised by many in the field.
However, since pseudoU is not native to the human body, is it safe?

For their study, the five scientists analyzed data in an article published in the peer-reviewed journal Frontiers in Immunology in October 2022, where a group of researchers in Thailand, using a melanoma mouse model, tested cancer development with mRNA vaccines. They found that all mRNA vaccines in which pseudoU replaced “U” stimulated cancer growth and metastasis (spread of cancer cells). The higher the percentage of pseudoU, the more severe the cancer growth.

Both the Pfizer and Moderna mRNA vaccines replace “U” with pseudoU 100 percent. This greatly contributed to the effectiveness of the COVID vaccines compared to unmodified mRNA vaccines, according to a 2021study titled “The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines.”
The body’s immune system can recognize the “U” component of foreign mRNA and trigger a cascade of immune responses. But substituting “U” with pseudoU removes that recognition and decreases innate immunogenicity, allowing cancer cells to grow uncontrollably.

Claims by Pfizer and Moderna​

The review article concluded that Pfizer and Moderna emphasized only the positive aspects related to replacing “U” with pseudoU when launching their vaccines. The new design makes the mRNA more stable, leading to more S (spike) protein produced and a more desirable immune response against SARS-CoV-2. The vaccine makers did not, however, provide information on the potential harms of the S protein, which is a known toxin, or on the potential side effects of avoiding an innate immune response.

I, for one, felt misled.

When I first learned that Pfizer was developing an mRNA-based vaccine, my reaction was “Oh, at least it’s not going to do much harm, as mRNA normally lasts only a few minutes in the body.” As a messenger, mRNA’s job is to deliver the message (of making a protein) and then quickly disappear.

My assumption was reinforced when the Centers for Disease Control and Prevention claimed: “After the body produces an immune response, it discards all of the vaccine ingredients, just as it would discard any substance that cells no longer need.”
Well, it turns out the mRNA is not what I thought.

By replacing every “U” with pseudoU, Pfizer and Moderna designed their vaccines to stay in the body longer to produce the S protein to trigger immune responses. The problem is that the modification made the molecules too stable, and thus they stay in the body for far too long.

Some of the consequences of this are now beginning to emerge.

S Protein Causes Cancer​

When we consider the possible harms from the COVID shot, we need to look at not only the components of the vaccine, i.e., the SARS-CoV-2 mRNA-LNP molecules that are being injected into human bodies, but also the recombinant S protein that the mRNA encodes for.
I wrote a column recently on the findings of a Japanese study on cancer development resulting from the COVID vaccine, in which I noted the additional harm caused by the S protein. A 2022 study by Oscar Solis and colleagues found that when the SARS-CoV-2 S protein is mixed with each of about 9,000 human proteins, the S protein binds well with human estrogen receptor alpha (ER-alpha).
ER-alpha is an important regulator in the body’s reproductive system. But when the cell carrying the vaccine molecules produces the S protein as encoded by the mRNA, the S protein then binds to ER-alpha, disrupting the cell’s normal function and leading to cancer development.

The mRNA vaccine is also found to weaken human cancer immunosurveillance, allowing easy growth of cancers.
As further proof, we now have the new review of N1-methyl-pseudouridine showing that pseudoU-containing mRNA vaccines foster cancer development.

Which Is Smarter, Science or Our Innate Immunity?​

National Institutes of Health scientists Dr. Jordan Meier and Dr. Kellie Nance have praised the invention of the COVID-19 vaccine using pseudoU.

“The modified nucleobase helps cloak mRNA vaccines from the immune system, limiting their undesired immune stimulation, and in certain circumstances may also enhance the synthesis of antigens by the protein-producing machinery of the cell,” they concluded in a 2021 paper. “This allows these vaccines to tap into the natural process of mRNA translation without triggering harmful side effects such as anaphylaxis.”

I wonder if Drs. Meier and Nance would draw the same conclusion today, given that so much information is emerging on the harms of the mRNA vaccine, especially when it comes to replacing “U” with pseudoU in the mRNA molecules.

The human body is a near-perfect design with a comprehensive immune system that protects it from harm while keeping a balance of things within the body’s environment. Weakening the immune system for short-term gain is dangerous and almost certain to have long-term adverse effects.

Replacing “U” with pseudoU may successfully protect mRNA vaccines from the recipient’s own immune system like a trojan horse; however, this trojan horse may eventually release hostile forces that could kill the host.

The “undesired immune stimulation” (from the NIH scientists and the mRNA vaccine’s perspective) is exactly what the body needs to protect itself, but the immune system can’t attack the invader because it’s been suppressed by pseudoU.

When treating a terminally ill patient, the doctor may endeavour to achieve the “desired” immune response to ensure survival at all costs, regardless of the side effects. However, that approach should not be used when healthy people are the subject.

Modern science is not yet advanced enough to fully understand the human immune system. For scientists to make “desired” versus “undesired” immune response decisions for hundreds of millions of healthy people via the jab is irresponsible and arrogant, to say the least.

In my recent column I commended the Springer Nature Group for allowing one of its medical journals, Cureus, to publish the Japanese study on cancer deaths after the third COVID shot. Now I’d like to commend Elsevier, the Dutch academic publishing company that owns renowned journals like The Lancet and Cell, for allowing its journal, International Journal of Biological Macromolecules, to publish the review article on pseudoU and cancer.

I am hopeful that top journals such as The Lancet and Nature will soon follow their sister publications and accept research papers on the harms of the COVID shot.

It is becoming increasingly clear that the mRNA vaccine is not safe and must be stopped.

 

psychgirl

Has No Life - Lives on TB
This sounds a lot like an adjuvant that was the “issue of the day” back when a vaccine came out for the h1n1 pandemic during Bbammy.
Wasn’t that one called squaline?…(or something like that I’m sure I’ve spelled it wrong)

I specifically remember DH and I searching which vaccines used it. He called a LOT of drugstores.

This was back when we both received flu vax for a couple of years, then never got any after that.
We were properly spooked.
 

dstraito

TB Fanatic
Find that pharmaceutical companies have been fraudulent resulting in death and injuries of people and impose the death penalty for all those involved, spreading the assets among the dead and injured.
 

Plain Jane

Just Plain Jane
Here's another one.


Health Canada Asked Pfizer For DNA Fragments Size In COVID Shots, Linked To 'Probability' Of Genomic 'Integration'​


BY TYLER DURDEN
TUESDAY, APR 30, 2024 - 09:40 PM
Authored by Noé Chartier via The Epoch Times (emphasis ours),
Canada’s drug regulator asked Pfizer to provide data on the size of DNA fragments in its COVID-19 vaccine, due to genomic integration concerns, shortly after learning the pharma giant withheld information on DNA sequences contained in its product.

“Concerning the residual plasmid DNA in the drug substance, provide data/information characterizing [...] the size distribution of the residual DNA fragments [and] residual intact circular plasmid,” says a request for clarification Health Canada issued to Pfizer on Aug. 4, 2023.

The information was released as part of records obtained through an access-to-information request. It shows, in part, that a Health Canada official was keeping the department’s counterparts in the United States and Europe apprised of the department’s interactions with Pfizer, in a bid to harmonize the regulators’ approaches regarding the recently discovered DNA fragment impurities.

“As you are aware, the fragment size is related to the probability of integration, and the WHO guidance assumes a fragment size of generally less than 200 bp,” Dr. Dean Smith, a senior scientific evaluator in Health Canada’s Vaccine Quality Division, wrote in an October 2023 email to counterparts at the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA).

DNA plasmids are used in the manufacturing process of mRNA vaccines and residual elements are supposed to be cleaned out below a certain threshold. Pfizer said DNA in its products is below the 10ng/dose guideline established by the World Health Organization (WHO) and followed by Health Canada, according to the official records.

This assertion has been challenged by independent scientists, who found quantities of DNA in the vaccines to be above the threshold. They have also found the DNA fragments are larger than 200 base pairs (bp).

Virologist Dr. David Speicher, who has studied Canadian mRNA vials, told The Epoch Times the average size of fragments his study found is 214 base pairs (bp), with some as large as 3.5 kilobase (kb).

While small fragments frequently integrate spontaneously into the genome, these mutations are stopped through either DNA repair mechanisms or cellular death, Dr. Speicher said.

Larger fragments are much more problematic, especially if attached to an SV40 enhancer, because they can integrate into the genome where they can get transcribed and then translated into proteins,” he added. Independent scientists like Dr. Speicher found the undisclosed SV40 enhancer in Pfizer shots, a piece of biotechnology used to drive gene expression.

Depending on the DNA fragment size, it can produce functional or aberrant proteins, Dr. Speicher explains. “These proteins can affect cellular metabolism, an immune response, as well as an increased risk for cancer. The risk of integration and associated health problems increases with the number of shots.”

The Florida State Surgeon General Dr. Joseph A. Ladapo has called for a halt of mRNA shots, citing concern about these risks. Dr. Philip Buckhaults, professor of cancer genomics and director of the Cancer Genetics Lab at the University of South Carolina, has initiated a study to investigate the risks.

Health Canada has not studied those risks, but told The Epoch Times last summer “the presence of residual plasmid DNA in the mRNA COVID-19 vaccines does not change the safety assessment of these vaccines.”

Seeking Clarifications

Despite providing this answer to media in the summer of 2023, Health Canada scientists were privately discussing working with international partners to have Pfizer remove DNA fragments and SV40 sequences from its vaccines and they prepared several requests for clarification to the company.

In an August 2023 email to a colleague providing information to relay to Pfizer, Health Canada senior biologist evaluator Dr. Michael Wall said his department would “continue to work with international regulatory partners to achieve harmonization regarding removal of these sequence elements from the plasmid for future strain changes.”

Records show Health Canada was blindsided by the presence of undisclosed genetic substances in the Pfizer-BioNTech vaccines, almost four years after the initial emergency authorization.

After Pfizer filed its submission for the authorization of its updated Omicron XBB.1.5 shot on July 21, 2023, Health Canada sent the company several Quality Clarifax—requests for additional information if deficiencies are identified in drug submissions—with the first one dated Aug. 4, 2023.

Regarding the residual plasmid DNA in the COVID-19 vaccines, Health Canada asked Pfizer to provide data on the size distribution of the DNA fragments and on residual intact circular plasmid.

Pfizer said this data was “not readily available and will require time to generate,” in a response on Aug. 11, 2023. The pharma giant added that Pfizer, the drug sponsor, and BioNTech, the manufacturer, had not been previously requested to provide this data across global markets.

Pfizer committed to provide the data by Dec. 1, but the response is not captured in the information package released under the access-to-information regime.

In a subsequent request for information sent on Aug. 22, 2023, Health Canada noted Pfizer’s commitment to provide the information and added a request by asking Pfizer to address “whether the residual DNA plasmid is capable of replication in bacteria.”

Virologist Dr. Speicher, commenting on the agency’s request, noted that plasmids need to be circular to be replicated in a bacterial host, and that fragments can’t do so.


So if they were intact circular plasmids and injected, they could be taken up by our host bacteria, especially in the gut,” he said. “If the plasmid could propagate in bacteria into our body it could lead to a bacterial spike factory and drive kanamycin/neomycin resistance.”

“This would cause an increase in antibiotic resistance of the bacteria including pathogens and increase spike production, and we know that spike is toxic on so many levels,” he said.

Dr. Speicher added that Pfizer should have tested for this before putting its products to market. The fact that it did not have the data indicates it did not test for it, he said.

SV40 Enhancer

The request for information that Health Canada sent to Pfizer mainly focused on the presence of the Simian Virus 40 (SV40) enhancer-promoter in the Pfizer-BioNTech shots.

Health Canada and other regulators like the FDA and EMA were not aware of its presence, since Pfizer “chose not to” disclose it, according to a separate email from Health Canada scientist Dr. Smith.

Many sections of the Clarifax are redacted under the Access to Information Act, with reasons such as content containing proprietary information or which could lead to a material gain or loss for a third party, in this case Pfizer and BioNTech.

The information disclosed shows that Health Canada challenged Pfizer on SV40 and asked for a “justification for the SV40 regulatory elements in the plasmid.”

Pfizer responded that the “SV40 regulatory region sequences [redacted] in the submission since this [redacted] is relevant neither for plasmid production in E. coli nor for production of mRNA.”

This is the position that has been adopted by Health Canada. In response to questions by the media and parliamentarians, the regulator has stated the SV40 enhancer-promoter is “inactive” and has “no functional role.”

But Pfizer and Health Canada have not addressed why the SV40 enhancer-promoter is present in the vaccine if it is not used in the production of mRNA and has no functional role. Genomics expert Kevin McKernan has questioned this when faced with responses from regulators.

Mr. McKernan made the initial DNA and SV40 fragments discovery and published his study in April 2023. His pre-print paper on the matter appears twice in the Health Canada information package released via access-to-information.

Mr. McKernan has pointed out that regulators could have discovered the SV40 sequences themselves had they run the plasmid through a computer annotation tool.

“If you ever used plasmid annotation tools, they annotate everything on the map and they don’t leave anything unannotated,” he told the International Covid Summit in February.

He provided his assessment to the summit of why Pfizer went this route. “They’re hiding the fact that this tool [SV40 enhancer] is used as a gene therapy tool and would classify their system as a gene therapy,” he said. “Because it’s a nuclear targeting sequence it moves DNA directly to the nucleus within hours in all cell lines.”

The American Society of Gene and Cell Therapy (ASGCT) classifies the mRNA injections as gene therapy, whereas Health Canada does not.

“The mRNA from the vaccines does not enter the cell nucleus or interact with the DNA at all, so it does not constitute gene therapy,” said Health Canada in a response to a parliamentarian on Dec. 13. The ASGCT also says the mRNA doesn’t alter the “recipient’s generic material” and is only present in the body “transiently.” However, because the vaccine introduces “new genetic material into cells for a short period of time to induce antibodies,” the American organization considers it gene therapy.

Pfizer said in a response to the Aug. 4 Health Canada request for information that the “SV40 promotor/enhancer DNA does not contain known oncogenes, infectious agents, or regions that could lead to functional transcripts, the DNA does not present any specific safety concerns.”

Health Canada also said in a document tabled in Parliament in March that “any claims the presence of the SV40 promoter enhancer sequence is linked to an increased risk of cancer are unfounded.” Health Canada itself has not studied the risks.

‘Drive Gene Expression’

A senior Health Canada’s scientist’s view on the role of SV40 fragments is captured in an Oct. 26 email written in response to questions from Chief Medical Officer Dr. Supriya Sharma.

Dr. Tong Wu of Health Canada’s Vaccine Quality Division responded that the “SV40 promoter enhancer is widely used to drive gene expression in mammalian cells.” He added, however, that it “serves no purpose in the manufacturing of Pfizer COVID-19 vaccines.”

Dr. Wu said it was unexpected to find the sequence in the finished product, since “Pfizer did not identify the presence of SV40 promoter enhancer on the plasmid template used to produce mRNA, in their original filing.”

Dr. Wu also said that “to the best of our knowledge,” no other vaccine approved in Canada contains the SV40 sequence.

Pfizer was contacted for comment, but the company hasn’t responded to inquiries.

Matthew Horwood contributed to this report.
 

Shadow

Swift, Silent,...Sleepy
Simian Virus 40 (SV40)
SV40 was also in the polio shot. When they suddenly discovered this contaminant they said "we will have a soft tissue cancer explosion in 30-40 years". This was about 1960 when a new generation electron microscope made the SV40 plainly evident.

I am suspicious though because it was well established that SV40 caused cancer prior to the polio vaccine development. One would think great effort would go into making sure it never entered a vaccine.

The CDC had this information on it's website for a short while. Someone may have saved it.

Shadow
 

energy_wave

Has No Life - Lives on TB
I had a friend who died two years ago from an unusually aggressive cancer. Most of her family were union teachers or in professions that have unions. Like clock work, she took the vacs and boosters. She made it into her late 50's before she died.
 

Hfcomms

EN66iq
Just found out today that I guy I work with his wife died from pancreatic cancer less than a month from being diagnosed. She had some lower back pain for awhile and by the time it was found it was already stage IV and growing rapidly. I don't know for sure whether or not either of them we're vaccinated but I have my suspicions. Lot's of people I know have had cancer within the last three years. Never have known this many people before for sure.
 
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