[continued from above post]
Remember: You can not just stack infinite numbers of immune cells in your lungs!
With every new infection by this new corona virus, your body will devote more of its limited immunological capacity to whatever it was taught to devote to this corona virus. If your body had to learn on its own to deploy plasmacytoid dendritic cells and NK cells to this virus, then that’s what it will do during successive infections.
If on the other hand, your body was taught to deploy an antibody response and CD8+ T cells against this virus, then these are the elements of the immune response that will take up more and more of your body’s scarce capacity to fight this virus. That will help it keep this evolving virus at bay (for now), but because these cells and antibodies generally have little ability to deal with unrelated respiratory viruses, it gets harder over time to deal with other respiratory viruses.
The T cells and B cells that deal with SARS2 are in competition with NK cells, but they are also to some degree in competition with T cells and B cells that deal with the other respiratory pathogens. Just as
the adaptive immunity against the seasonal corona viruses interferes with immunity against SARS2, the opposite is seen too, as
SARS2 antibodies react with Influenza. This means there is interference with the adaptive immune response to other respiratory pathogens.
The adaptive immune response against respiratory viruses is intended for problems the innate immune system could not deal with on its own. It inherently takes the adaptive immune system more time to deal with an infection, hence we see that vaccinated people take longer to bring the viral load back to zero. As a result, the damage that these constant reinfections can do to the immune system is exacerbated too.
This affects everyone to some degree. If you were vaccinated, your body has a more difficult time fighting off these viruses. We have known this for a long time, we see it with the influenza vaccine too. We vaccinate children with inactivated vaccines against influenza and we observe that it works to protect them against influenza, but
now they’re more vulnerable to respiratory infections by other viruses! For SARS-COV-2, you can expect a similar effect.
For everyone who was not vaccinated, there is increased exposure to respiratory viruses, from all the people who are infected by these viruses. This leads to an increase in respiratory infections, especially in young children whose immune systems have not yet had sufficient training against the variety of those viruses that circulate.
This would be bad enough, if we now had a very competent highly specific immune response against SARS-COV-2. But as I have explained a number of times in previous articles, the immune response deployed by people’s bodies is not even well-suited for SARS-COV-2! People are now deploying IgG4 antibodies that are poorly suited for neutralizing viral particles, but worst of all, don’t tell your T cells and your NK cells to kill infected cells!
Instead, these IgG4 antibodies tell almost all your immune cells to calm down, by binding to their FcγRIIb receptor. This means that when these antibodies bind to your plasmacytoid dendritic cells,
they tell them to calm down and stop releasing interferon. This then in turn means that these plasmacytoid dendritic cells are not activating your natural killer cells either. And again, we can expect that this abnormal antibody response will interfere in the response against other respiratory pathogens too.
I can not sufficiently emphasize how nightmarish this problem is. It effectively shuts down all the pro-inflammatory messaging that your immune cells produce, that encourages infected cells to destroy the viral RNA that infected them, warns the neighboring vulnerable cells there is a virus present and encourages other immune cells to get active. You will have reduced symptoms of the infection as a result, while the virus happily spreads through your cells. That is insanely dangerous when dealing with a virus like this, that has the inherent ability to spread by fusing an infected cell together with an uninfected cells.
Infections don’t solve this problem, they make it steadily worse. The first signs are seen after two shots, but it only becomes significant once those two shots are followed by an infection. We have not seen a fraction yet of what this problem will cause, because respiratory pathogens like SARS2 will evolve in response to this abnormal immune response to abuse it. You can expect an increase in asymptomatic infections from a variety of respiratory pathogens. The absurd rates of pneumonia now seen in children may be largely a result of them constantly being exposed to those asymptomatic carriers. I have been warning for a long time now, that some solution needs to be sought to remove these B cells doing this, but nothing is being done.
I will emphasize once again: There is
still no evidence of this problem happening to anyone other than people who received these mRNA vaccines, because it’s not normal and not part of any sort of normal compensatory mechanism either. It’s what happens by placing extreme demands on the adaptive immune system, while intentionally fooling the cellular innate immune system into going along. Those two very contrasting signals coming from the innate and the adaptive immune system lead the immune system to think it’s overreacting to an environmental contaminant that does not infect cells, thus encouraging a class switch.
I have said from day one, that if we want to override how our immune system would normally respond to a new virus like this, we need to be really sure of what we’re doing. But for some reason, humanity decided to go with a very experimental new technique, that has now led to a very unusual adaptive immune response that is entirely incorrect for a virus of this nature.
If we were dealing with a new strain of influenza, this would be bad enough. But we’re dealing with a coronavirus, one most closely related to viruses that persistently infect bats. These viruses are very good at persistently infecting a host, if you give them a chance, because unlike Influenza, they are naturally good at suppressing the body’s interferon response. Well, if your body deploys antibodies against this virus that fail to instruct your NK cells and your CD8 T cells to kill infected cells, then that’s what you’re encouraging in these viruses.
The broken immune response people deploy against this virus is encouraging this virus to evolve into a persistent infection, that spreads by fusing an infected cell to neighboring cells. This is hugely damaging for your body, you don’t want your cells to be fusing together with neighboring cells. Yet, this is the best route to survival available for the virus, when the antibodies are IgG4 antibodies that don’t instruct cytotoxic cells to kill infected cells.
The broken balance of the immune response seen in people’s lungs due to vaccination, is not stable. It continues to escalate towards increasing dependence on B and T cells with every additional vaccine against SARS-COV-2, as well as with every additional SARS-COV-2 infection that recalls this poorly effective adaptive immune response.
The big change in the virus from Delta to Omicron did not encourage a new immune response, but
merely recalled the vaccine induced adaptive immune response. Every subsequent subtle change to the virus then again recalled this adaptive immune response.
The virus in turn continues to evolve to get better at evading this broken immune response, by reducing the immunogenicity of Spike and improving Interferon suppression. This then forces the immune system to rely even more on it. With the evidence we have, we can say that the cannabis plant appears like an effective candidate to address this harmful cycle.
So what’s going to happen now? Well as I explained before, the virus will continue to evolve, to use people’s broken immune response to its advantage. You see versions emerge everywhere now, that
have improved the Furin cleavage site, which allows it to fuse cells together. Fuse cells together and you never have to worry about the antibodies neutralizing your viral particles, you can spread undetected!
More importantly however, we have an increasingly clear picture of what is going to happen to the evolution of this virus. People’s immune systems are now very dependent on antibodies against a particular region of the N-Terminal Domain: The antigenic supersite. This site mostly consists of three loops (corresponding to amino acids 14-26 (N1), 141-156 (N3) and 246-260 (N5)). It now mostly seems to be IgM antibodies.
So what’s happening instead, is that these regions are undergoing deletions. The first example
has already been seen of this in South Africa. When this happens, the virus starts looking more like SARS1 and other Sarbecoviruses in bats. It avoids these antibodies, but has the added effect of making it easier to fuse cells together. The only reason it hasn’t happened on a wide scale yet, is because it makes transmission to other people more difficult.
You can see that this deletion of the antigenic supersite is the direction the virus is going, by looking at the variants now emerging. The recently seen South African variant deletes 15-27 and 136-146, so it gets rid of N1 and most of N3.
The important thing to keep in mind, is that IgM antibodies normally don’t last very long. They’re produced for a few weeks, then decline. When antibodies are needed to produce lasting protection against infection, you need IgG antibodies. This means that if protection now depends on IgM against the highly immunogenic region of the NTD, you will now have a situation where people are just reinfected after a few weeks.
This means you get suboptimal pressure on the immunogenic region of the NTD: These antibodies will neutralize most viral particles and stop the virus from spreading to other people, but they won’t effectively neutralize all viral particles. Under those conditions, you start to encourage rare mutations in the immunogenic region of the NTD to spread. This includes the rare large deletions in these loops.
So what’s going to happen now?
In the weeks ahead, we’re going to see versions of SARS2 spread that have improved their ability to establish chronic infections. There are multiple routes for this. The BA.2.86 versions can take the backbone of the other versions. But equally important, there’s a very easy path to improve the Furin cleavage site (S:679R), thereby making it easier to spread from one cell to another.
These increasingly chronic infections are hard to test for and they’re associated with other secondary viral and bacterial infections. A lot of the observed pneumonia in people right now is SARS2 that’s simply going unrecognized.
Eventually, we will see the same thing as we recently saw in South Africa: These persistent infections will end up with shorter loops in the N-Terminal Domain, turning this virus into something more similar to the original SARS. You will see deletions emerge in these regions: 14-26 (N1), 141-156 (N3) and 246-260 (N5).
You may also see mutations of amino acids to Serine or Threonine, either within these regions, or around them. Once you see this happen, you can expect a rapid increase in virulence. It will be impossible to deny something is seriously wrong. An awful lot of people will get very sick simultaneously.
Once we reach this point, there will be no places left where antibodies can bind and neutralize the Spike protein, because the whole RBD either looks similar to our own amino acids, or is shielded by the glycans. Binding to the glycans seems to be insufficient to neutralize the Spike protein, but causes autoimmune problems, as these antibodies also bind to your own cells glycans.
Because people’s immune systems have spent the past three years, devoting more and more of their limited capacity to this adaptive immune response of antibodies and T cells, proliferating these cells at the cost of the innate immune system’s ability to do its job, now treating this Spike protein as if it were a kind of strange new bee venom or pollen that is continually showing up in our lungs somehow, the loss of these immunogenic regions of the N-Terminal Domain would suddenly leave most people in highly vaccinated Western countries with no protection.
The immune system would likely resort to antibodies against the glycan shield (something already being observed in severe cases), which results in acute autoimmune problems and generally fails to neutralize the Spike protein.
It’s hard to see how that could result in anything other than a sudden outbreak of severe disease in most of the population.
On the other hand, among people with natural immunity, the innate immune system would continue to do its job:
-NK cells have proliferated, adjusted their receptor repertoire and know when to strike.
-Plasmacytoid dendritic cells have proliferated and are not told to shut down by IgG4 antibodies.
This is my warning. And as the unexplained deaths continue to pile up, as the children have record levels of pneumonia, as more people every week go to the doctor with coughs and respiratory infections that don’t seem to go away, I hope people will take it seriously. The problems you caused take time to reveal themselves, but they are now becoming undeniable.