CORONA Main Coronavirus thread
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Zoner
Veteran Member
According to the comments in the sub stack Malone is the one Geert is talking about.
naegling62
Veteran Member
I'll take Geert over Malone any day.
psychgirl
Has No Life - Lives on TB
Zpak IS what DH was prescribed when he was in dire straits with pneumonia!
He improved rapidly after starting those.
northern watch
TB Fanatic
Profit of Doom
Dismember
Too bad we don’t have any treatments against these kinds of virus.
Heliobas Disciple
TB Fanatic
Supreme Court Denies Appeal of AstraZeneca Employee Fired for Refusing the Shot for Religious Reasons
A former AstraZeneca employee sought unemployment benefits after she was fired for refusing the COVID-19 vaccine.
www.theepochtimes.com
Supreme Court Denies Appeal of AstraZeneca Employee Fired for Refusing the Shot for Religious Reasons
A former AstraZeneca employee sought unemployment benefits after she was fired for refusing the COVID-19 vaccine.
By Matthew Vadum
4/1/2024
The Supreme Court refused to hear an appeal from a former AstraZeneca sales manager who was denied unemployment benefits after the vaccine maker fired her for declining on religious grounds to receive a COVID-19 vaccination.
The British–Swedish company AstraZeneca makes the Oxford–AstraZeneca SARS-CoV-2 vaccine, which is marketed under the names Covishield and Vaxzevria. The company also makes Esomeprazole, which is sold as Nexium, a medication that treats gastroesophageal reflux disease.
The company experienced adverse publicity in the West a year ago when AstraZeneca’s Chinese division president, Wang Lei, said the company aims to be a “patriotic” company in China that “loves the Communist Party.”
The nation’s highest court refused to grant the petition for certiorari, or review, in Goede v. AstraZeneca Pharmaceuticals LP in an unsigned order on April 1. No justices dissented. The court did not explain its decision. The justices had considered the petition at their private conferences on Feb. 16 and March 28. For a petition to advance to the oral arguments stage, at least four of the nine justices must vote in favor of granting it.
The ruling leaves in place a June 2023 decision by the Minnesota Court of Appeals, which upheld the Minnesota Department of Employment and Economic Development’s determination that Tina Goede’s refusal of the vaccine was “employment misconduct” that rendered her ineligible for unemployment benefits. The state appeals court decision was affirmed by the Minnesota Supreme Court in September 2023.
Ms. Goede filed a petition with the Supreme Court on Dec. 18, 2023, stating that AstraZeneca fired her “because it refused to accommodate her sincerely held religious beliefs, and she refused to compromise those beliefs by taking a COVID-19 vaccine which she believes was developed using aborted fetal cells ... and which she also believes is harmful to her body, which she believes is a ‘temple of the Holy Spirit.’”
She considers herself a pro-life Catholic who believes that “abortion is the murder of an unborn child, and, therefore, she cannot, in good conscience, receive a medical intervention tested on or developed using cell lines from an aborted fetus without being complicit in sin.”
Ms. Goede said she has retained these beliefs for 20 years. For 10 years, “she has researched medical interventions she considers receiving and routinely verifies whether they involve materials derived from abortion before receiving them.”
She stopped taking over-the-counter painkillers a decade ago because she came to believe that “they were tested on cell lines from an aborted fetus.” She testified that “she would only ever use a substance tested on or derived from aborted fetal-cell lines to prevent her death,” the petition states.
Claim for Benefits Is Denied
When Ms. Goede sought unemployment benefits, the Minnesota Department of Employment and Economic Development, which is also a respondent in the Supreme Court proceeding, “wrongfully” denied her claim for benefits, according to the document.
She made clear her religious objections to the COVID-19 vaccine and her First Amendment rights throughout the administrative and court proceedings. In front of the department’s unemployment law judge, she said she could not receive the vaccination because of her religious principles. But despite this, the judge ruled against her.
Ms. Goede appealed to the Minnesota Court of Appeals, claiming that the denial of benefits ran afoul of her First Amendment rights. The court affirmed the judge’s ruling, rejecting her First Amendment arguments. She appealed to the Minnesota Supreme Court, but it rejected her petition.
On Jan. 12, AstraZeneca waived its right to respond to the petition, but on Feb. 23, Minnesota Attorney General Keith Ellison, a Democrat, filed a brief on behalf of the department opposing the petition.
“In her petition, Ms. Goede primarily objects to the misapplication of settled law and does not otherwise present compelling reasons for this Court to review this case. Even if she had presented compelling reasons, this case would be a poor vehicle to develop First Amendment jurisprudence,” the brief reads.
The department noted that Ms. Goede’s employment with AstraZeneca took place during the recent COVID-19 pandemic. At that time, the company implemented a policy requiring its employees to receive the COVID-19 vaccine, but Ms. Goede refused to comply.
She testified that some hospitals or clinics maintained a vaccination requirement for vendors, including one of the larger health systems in Minnesota, so she could not attend at their facilities because she was not vaccinated, even though her job responsibilities required visiting hospitals and clinics.
Ms. Goede asked the company to exempt her from the policy, but the request was denied, and she was removed from her position in April 2022. The department took the position that the vaccination policy was reasonable and that her failure to abide by it constituted employment misconduct, according to the brief.
The unemployment law judge asked her detailed questions about her beliefs and religion, and she testified that her priest urged her not to get vaccinated. She said she would never accept the vaccine regardless of how it was developed “because the vaccine doesn’t work.”
The judge held that Ms. Goede did not possess “a sincerely held religious belief that prevents her from receiving a COVID-19 vaccine and that it was not credible that she had such a sincerely held religious belief,” according to the brief.
The judge found that she “declined to be vaccinated because of a lack of trust and not because of a religious belief.” The company had a right to expect its employees to receive the vaccine, and her refusal to do so was “a serious violation of her employer’s reasonable expectations.”
Because applicants for unemployment benefits who are fired for employment misconduct are not eligible for those benefits under state law, the judge found Ms. Goede was ineligible.
“No compelling reasons warrant review” by the Supreme Court, the department stated.
Heliobas Disciple
TB Fanatic
https://kunstler.com/cluster****-nation/this-is-not-an-april-fools-gag/
(fair use applies)This Is Not an April Fool’s Gag
“I’m sorry for the harsh message, but somebody needs to tell the truth,” virologist Dr. Geert Vanden Bossche
Howard Kunstler
April 1, 2024
Did you have a fabulous Transgender Visibility Day, uncluttered with any loose talk about one Jesus Christ and his travails in the Roman Levant some 2000 years ago? The Easter Bunny desisted from twerking on the White House lawn this time around, but the Party of Chaos still nailed down the vote of the .000429 percent of the population that identifies as opposite the clerical error made upon their sexual assignment at birth. All in all, this may be the last grotesque frivolity the political class indulges in for a long time to come, and I’ll tell you why.
I had the honor of interviewing the Belgian virologist Geert Vanden Bossche on Friday for my podcast, and he had quite a sobering message. “What I am predicting,” he said, “is a massive, massive tsunami” of illness and death among highly-vaccinated populations with dysregulated immune systems.
“You commit errors or even crimes at the very small scale, you can hide them,” he said (at around 47:00 minutes into the hour-long discussion). “I have seen this happen with the Ebola vaccination with Africa a number of years ago. . . . However, if you do this at the very large scale, like what has happened with this mass [Covid] vaccination campaign, the truth will surface. And those who have committed these crimes who have been lying to the people, who have not been taking care of the health and safety of the people, will be severely, severely punished. . . . If these people would now go out and say, ‘Yeah, wait a minute, we have been making some mistakes, it wasn’t all right, we have to correct them, we have to revise our opinion,’ these people will be stoned in the streets. . . . They can only hope that something will happen that will distract from this issue, but it won’t. . . . The truth will surface: this has been a large-scale experiment of gain-of-function on the very human population. This will be something that will be reported in history for many many generations to come.”
A bit further on (around 55:20 minutes) he says, “You will see what will happen, for example, in the next coming weeks. . . is more and more cases of more serious long Covid. . . . They will start to replace the surge of the cancers. . . now we have a more chronic phase. It will end with a hyper-acute phase, a huge, huge wave. . . I’ve been studying this now for four years. I know what I’m talking about. I’m probably the only person, in all modesty, who understands the immunology behind this. . . . (At 1:00:12) The thing I want your audience to understand, what we will be facing in the hyper-acute Covid crisis that is imminent, is that we will have to build a completely new world. . . . It is very very clear that when this starts, our hospitals will collapse. And that means the chaos in all kinds of layers of society — financial, economic, social, you name it — will be complete. And that is what I’m very clearly predicting. . . . It’s very strange for me to make such statements, but I’m not hiding it because I’m two hundred percent convinced that it will happen.”
Now that you’ve had an ice-cold shower, consider some further implications of this scenario. One is that the government and its public health officials may try to attribute the blame for this to the “Disease X” story they’ve been peddling for about a year, the “next pandemic,” something entirely new. That will not be true. They will be trying to cover their asses. Rather, this next episode will be the result of the epic blunders they already made, beginning in 2020, with the emergence of Covid-19. The variant that causes the coming hyper-acute crisis will be quite different from the original “Wuhan” strain, but it will be a direct descendent of it, having mutated in the bodies of the vaccinated. It was, after all, Dr. Vanden Bossche who declared at the outset of the Covid vaxx melodrama in 2021 that vaccinating into the teeth of an ongoing pandemic disease was absolutely the wrong strategy from an immunological point-of-view, and sure to produce a grievous outcome.
What, if anything, can you do to prepare for this? Dr. Vanden Bossche is also very clear: “What I can advise. . . to all these vaccinated people: they need to avoid reinfection. It is the reinfection of vaccinated people that is responsible for this situation. . . . Well, the only thing they can do — it’s very simple — is take anti-virals, of course. The only difference is, you will not be able to wait to take anti-virals until you have symptoms. . . . As soon as people see that in one of the other countries, or one of the other states in the United States, when this starts with hospitalizations going up very rapidly, they need to take anti-virals prophylactically, not wait until they have any symptoms. I’m in Belgium. If it starts in the US, or starts in Israel, or starts in the UK, I bet you that within a few days, you will see the same scenario in many of the highly-vaccinated countries.”
By “anti-virals,” Dr. Vanden Bossche means specifically Ivermectin, the Nobel Prize-winning drug that the FDA and the CDC demonized brutally in order to distract the public from knowing that there was a safe and effective treatment for Covid. To acknowledge that would have vacated Pfizer’s and Moderna’s Emergency Use Authorization, which allowed them to make tens of billions of dollars on a very poorly tested pharma product while enjoying blanket protection against lawsuits.
“I have been predicting already a half a year ago, that the public health authorities are finally going to have mandates for ivermectin.” Dr. Vanden Bossche said. “The results with ivermectin are fabulous. It is very safe. It is the only anti-viral that is cost-effective, that is widely available, that can be supplemented in sufficient quantities. . . . There is simply no alternative.”
Note that just last week, as a result of a lawsuit brought in the Texas Southern District federal court, the FDA agreed to finally take down the social media messages it had put up to lawlessly block the use of ivermectin. Remember the mocking tweet: “You’re not a horse, you’re not a cow, come on y’all.” The truth was that the FDA had no authority to tell doctors how to practice medicine; nor to block FDA-approved drugs (including ivermectin), even for off-label treatments. Off-label treatment with approved drugs is routine in medicine. Instead of ivermectin, US public health officials pushed the use of unsafe remdesivir with intubation, resulting in many thousands of avoidable deaths. This is only one of the crimes they will have to answer for.
If Dr. Vanden Bossche’s scenario comes to pass, the “hyper-acute Covid crisis” will intersect with the elections of 2024, and not just in the USA. You would naturally expect some extreme despotic hysterics out of the “Joe Biden” government. They will surely try to run their “Disease X” ruse. But they have already lost the trust of the people they made war against in their own country. In which case, expect resistance among the un-sick. No more trips will be laid on us.
Link to podcast:
KunstlerCast 398 — Dr. Geert Vanden Bossche and the Coming Acute Crisis of Covid among the Vaccinated - Kunstler
S upport this blog by visiting Jim’s Patreon Page And thanks to all my Patrons for your support! Geert Vanden Bossche is a globally renowned virologist working in Belgium. He predicts a “hyper-acute crisis” of Covid-19 illness among highly-vaccinated populations emerging shortly across the...
kunstler.com
Zoner
Veteran Member
Thanks for posting this. This is going to be quite the year. Disease, war, financial collapse, supply line shortages leading to much sickness and death, and spiritual confusion everywhere.(fair use applies)
This Is Not an April Fool’s Gag
“I’m sorry for the harsh message, but somebody needs to tell the truth,” virologist Dr. Geert Vanden Bossche
Howard Kunstler
April 1, 2024
Did you have a fabulous Transgender Visibility Day, uncluttered with any loose talk about one Jesus Christ and his travails in the Roman Levant some 2000 years ago? The Easter Bunny desisted from twerking on the White House lawn this time around, but the Party of Chaos still nailed down the vote of the .000429 percent of the population that identifies as opposite the clerical error made upon their sexual assignment at birth. All in all, this may be the last grotesque frivolity the political class indulges in for a long time to come, and I’ll tell you why.
I had the honor of interviewing the Belgian virologist Geert Vanden Bossche on Friday for my podcast, and he had quite a sobering message. “What I am predicting,” he said, “is a massive, massive tsunami” of illness and death among highly-vaccinated populations with dysregulated immune systems.
“You commit errors or even crimes at the very small scale, you can hide them,” he said (at around 47:00 minutes into the hour-long discussion). “I have seen this happen with the Ebola vaccination with Africa a number of years ago. . . . However, if you do this at the very large scale, like what has happened with this mass [Covid] vaccination campaign, the truth will surface. And those who have committed these crimes who have been lying to the people, who have not been taking care of the health and safety of the people, will be severely, severely punished. . . . If these people would now go out and say, ‘Yeah, wait a minute, we have been making some mistakes, it wasn’t all right, we have to correct them, we have to revise our opinion,’ these people will be stoned in the streets. . . . They can only hope that something will happen that will distract from this issue, but it won’t. . . . The truth will surface: this has been a large-scale experiment of gain-of-function on the very human population. This will be something that will be reported in history for many many generations to come.”
A bit further on (around 55:20 minutes) he says, “You will see what will happen, for example, in the next coming weeks. . . is more and more cases of more serious long Covid. . . . They will start to replace the surge of the cancers. . . now we have a more chronic phase. It will end with a hyper-acute phase, a huge, huge wave. . . I’ve been studying this now for four years. I know what I’m talking about. I’m probably the only person, in all modesty, who understands the immunology behind this. . . . (At 1:00:12) The thing I want your audience to understand, what we will be facing in the hyper-acute Covid crisis that is imminent, is that we will have to build a completely new world. . . . It is very very clear that when this starts, our hospitals will collapse. And that means the chaos in all kinds of layers of society — financial, economic, social, you name it — will be complete. And that is what I’m very clearly predicting. . . . It’s very strange for me to make such statements, but I’m not hiding it because I’m two hundred percent convinced that it will happen.”
Now that you’ve had an ice-cold shower, consider some further implications of this scenario. One is that the government and its public health officials may try to attribute the blame for this to the “Disease X” story they’ve been peddling for about a year, the “next pandemic,” something entirely new. That will not be true. They will be trying to cover their asses. Rather, this next episode will be the result of the epic blunders they already made, beginning in 2020, with the emergence of Covid-19. The variant that causes the coming hyper-acute crisis will be quite different from the original “Wuhan” strain, but it will be a direct descendent of it, having mutated in the bodies of the vaccinated. It was, after all, Dr. Vanden Bossche who declared at the outset of the Covid vaxx melodrama in 2021 that vaccinating into the teeth of an ongoing pandemic disease was absolutely the wrong strategy from an immunological point-of-view, and sure to produce a grievous outcome.
What, if anything, can you do to prepare for this? Dr. Vanden Bossche is also very clear: “What I can advise. . . to all these vaccinated people: they need to avoid reinfection. It is the reinfection of vaccinated people that is responsible for this situation. . . . Well, the only thing they can do — it’s very simple — is take anti-virals, of course. The only difference is, you will not be able to wait to take anti-virals until you have symptoms. . . . As soon as people see that in one of the other countries, or one of the other states in the United States, when this starts with hospitalizations going up very rapidly, they need to take anti-virals prophylactically, not wait until they have any symptoms. I’m in Belgium. If it starts in the US, or starts in Israel, or starts in the UK, I bet you that within a few days, you will see the same scenario in many of the highly-vaccinated countries.”
By “anti-virals,” Dr. Vanden Bossche means specifically Ivermectin, the Nobel Prize-winning drug that the FDA and the CDC demonized brutally in order to distract the public from knowing that there was a safe and effective treatment for Covid. To acknowledge that would have vacated Pfizer’s and Moderna’s Emergency Use Authorization, which allowed them to make tens of billions of dollars on a very poorly tested pharma product while enjoying blanket protection against lawsuits.
“I have been predicting already a half a year ago, that the public health authorities are finally going to have mandates for ivermectin.” Dr. Vanden Bossche said. “The results with ivermectin are fabulous. It is very safe. It is the only anti-viral that is cost-effective, that is widely available, that can be supplemented in sufficient quantities. . . . There is simply no alternative.”
Note that just last week, as a result of a lawsuit brought in the Texas Southern District federal court, the FDA agreed to finally take down the social media messages it had put up to lawlessly block the use of ivermectin. Remember the mocking tweet: “You’re not a horse, you’re not a cow, come on y’all.” The truth was that the FDA had no authority to tell doctors how to practice medicine; nor to block FDA-approved drugs (including ivermectin), even for off-label treatments. Off-label treatment with approved drugs is routine in medicine. Instead of ivermectin, US public health officials pushed the use of unsafe remdesivir with intubation, resulting in many thousands of avoidable deaths. This is only one of the crimes they will have to answer for.
If Dr. Vanden Bossche’s scenario comes to pass, the “hyper-acute Covid crisis” will intersect with the elections of 2024, and not just in the USA. You would naturally expect some extreme despotic hysterics out of the “Joe Biden” government. They will surely try to run their “Disease X” ruse. But they have already lost the trust of the people they made war against in their own country. In which case, expect resistance among the un-sick. No more trips will be laid on us.
Link to podcast:
1hr 5min 51secKunstlerCast 398 — Dr. Geert Vanden Bossche and the Coming Acute Crisis of Covid among the Vaccinated - Kunstler
S upport this blog by visiting Jim’s Patreon Page And thanks to all my Patrons for your support! Geert Vanden Bossche is a globally renowned virologist working in Belgium. He predicts a “hyper-acute crisis” of Covid-19 illness among highly-vaccinated populations emerging shortly across the...kunstler.com
Zoner
Veteran Member
March 30, 2024
People often speculate that if my predictions come true (of which I remain 100% convinced), the unvaccinated will once again be scapegoated for exacerbating the public health damage caused by the virus. However, I firmly believe this won't be the case, as it will become unmistakably clear that cases of enhanced severe Covid-19 (C-19) disease will almost1 exclusively occur among the C-19 vaccinated, leaving healthy unvaccinated individuals unaffected.
However, what is more probable is that public health authorities and self-proclaimed health experts will assert that the pandemic, which they believed was receding, has suddenly surged again due to the growing vaccine hesitancy. Consequently, they may argue that the immune system of people who decline updated C-19 vaccines is at risk of being overwhelmed by the current circulating, highly infectious SARS-CoV-2 (SC-2) variants and that many of them will therefore contract chronic SC-2 infections. As a result, they would persistently shed their own ‘home-made’ variants , so-called ‘cryptic’ lineages2,3 that typically are very peculiar and always contained in one place (i.e., primarily localized where the allegedly chronically infected person resides).
Well, it’s just going to be another significant misinterpretation on their part. This misinterpretation, however, conveniently suits them well as it could absolve them of any guilt (but not in the mind of those who read some of my more recent contributions to this topic4).
I will now explain why this can be considered the final and most significant step in the virus's immune escape strategy, marking the beginning of the end of the immune escape pandemic:
7 Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant - Nature Communications
---
First, as the virus gains the upper hand, the pain worsens for vaccinated hosts. This is because diminished Ag uptake may no longer allow universal pathogen-derived peptides to activate CTL responses, but instead prime CD8+ T cells directed at the self-mimicking universal peptide. Provided sufficient upregulation of MHC molecules, the presentation of promiscuous/ universal microbial T cell (Tc) peptides, sharing sufficient structural homology with certain self-peptides, may lay the foundation for the pathogenesis of autoimmune diseases via a phenomenon termed degeneracy of Ag recognition of TCR (T cell receptor)
recognition8,9,10,11.
The priming of autoreactive T cells can be attributed to cross-reactivity between pathogen-derived and self-antigens (molecular mimicry). The chronic antigenic stimulation of circulating autoreactive T cells directed towards tissue-specific self-antigens, likely underlies the pathogenesis of Long Covid. The
severity of this chronic T cell-mediated autoimmune disease presumably hinges on the extent of virus internalization into APCs and subsequent presentation of universal Tc peptides on cell surface-expressed MHC class I molecules. This suggests that both the prevalence and severity of Long Covid cases are poised to rise alongside the evolution of the virus towards an increasingly narrow range of more transmissible variants causing vaccine breakthrough infections (VBTIs) in highly C-19 vaccinated populations. Since the pathogenesis of Long Covid likely involves the degenerate recognition of a universal self-like Tc peptide12,
it’s not surprising to observe that the occurrence and severity of Long Covid are independent of the patient’s genetic MHC background.
Anticipating that the potent and universal CTL activation (coupled with exhaustion of Ag-specific CD8+ T cells!) will be mitigated due to enhanced adsorption of more infectious variants to DC-tethered virions (see fig. 2), we may witness a surge in T cell-mediated autoimmune diseases replacing the surges of turbo cancers. Given that the onset or exacerbation of Long Covid is likely triggered by re-exposure to circulating virus, the diagnosis of Long Covid often correlates with a positive PCR assay or Ag test. However, correlation does not necessarily imply causation, and there's no evidence to support the notion that the chronicity of this condition stems from persistent viral replication.
Based on the proposed dynamics of the interaction between the virus and population-level immunity, it seems reasonable to attribute the chronicity of this condition to the recall of previously induced Ab responses in previously C-19 vaccinated individuals. Therefore, I would prefer to designate this chronic
disease as vaccine-associated autoimmune disease rather than Long Covid, as the former better underscores the immune pathological nature of this condition and its prevalence among C-19 vaccinees.
Finally, it is crucial to recognize that the days of the JN.1 descendants are numbered. With an increasing trend towards the adsorption of viral particles to URT-resident DCs, the concentration of Ab-virus complexes capable of recalling PNNAbs is declining while activated APCs become potent stimulators of autoreactive CD8+ T cells (see further below) but do not activate foreign-centered CD4+ T helper cells. Consequently, PNNAbs titers gradually become rate-limiting for inhibiting viral trans infection. As a result, highly C-19 vaccinated populations are exerting increasing immune pressure on the 'enhancing' antigenic site within the N-terminal domain of S protein (S-NTD) responsible for binding the PNNAbs13 in highly C- 19 vaccinated populations.
However, due to their misunderstanding of Long Covid's pathogenesis and their ignorance regarding the escalating immune pressure on viral virulence, public health authorities may conveniently attribute the increasing prevalence of Long Covid cases in highly C-19 vaccinated populations to the perceived inadequacy of the population’s coverage rate by updated C-19 vaccines.
Conclusion:
I hope this report unequivocally demonstrates that Long Covid patients are not a persistent source for currently detected highly transmissible lineages or for future highly virulent cryptic lineages. Instead, these patients suffer from immune pathological consequences stemming from SIR-enabling VBTIs within highly C-19 vaccinated populations. SIR-enabling VBTIs, and thus the sporadic and temporary emergence of cryptic SC-2 lineages and the accompanying so-called Long Covid cases, are merely the consequences of escalating immune escape and immune pressure originating from mass vaccination and eventually driving the virus to evolve with remarkable gain-of-function (see fig. 1).
Mass vaccination, rather than the lack of acceptance of updated C-19 vaccinations, is the sole cause of the seemingly perpetual cycle of viral immune escape and the accompanying rise in chronic immune pathology (referred to as ‘Long Covid’). However, the increasing incidence of Long Covid cases, coupled with the evolution of JN.1 descendants towards higher levels of intrinsic infectiousness, serves as the harbinger of a dramatic wave of highly virulent VBTIs that will ultimately put an end to the large-scale gain-of-function experiment conducted in highly C-19 vaccinated populations.
There shall be no doubt that the responsibility of this unprecedented gain-of-function experiment on the very human species solely lies with those who orchestrated this mass vaccination program. Neither patients dealing with Long Covid nor individuals who declined the C-19 vaccination or rejected the updated boosters, can be blamed for the increasing incidence of Long Covid and the looming disaster that could have been prevented if the principle of "First, do no harm" had been honored.
Fig.1: The immune escape pandemic in a nutshell. Large-scale infection-prevention measurescombined with mass C-19 vaccination resulted in large-scale gain-of-function (from asymptomatic-mild infection by Wuhan-Hu-1 lineage to (PNN)Ab-dependentenhancement of severe C-19 disease by HIVICRON).
Fig. 2: Early Omicron descendants enter target host cells via PNNAb-dependent enhancement of infection (1). PNNAbs bind to progeny virus tethered to these DCs, which subsequently migrate to the lungs and other distal organs (2). On the other hand, previously SIR-primed Abs bind with low-affinity to the antigenically more distant immune escape variant, thereby generating Ab-virus complexes that are taken up into patrolling APCs (3). Enhanced uptake of large Ab-virus complexes into APCs facilitates strong activation of CTLs, thereby enabling the elimination of virus-infected host while impeding T help to assist in boosting of previously SIR-primed Abs. Diminished boosting of previously primed anti-S Abs results in diminished production of PNNAbs. Highly infectious Omicron descendants do not rely on PNNAb-dependent enhancement of infection to enter target host cells. Replication of highly infectious variants generates an immunological environment that promotes their adsorption onto tissue-resident DCs. Due to their high level of intrinsic infectiousness, newly emerging, more transmissible Omicron descendants (e.g., members of the JN.1 clan) will therefore enhance the adsorption of progeny virions on migratory DCs and thereby reduce viral uptake by APCs. As these highly infectious variants are steadily growing in prevalence, diminished production of PNNAbs, combined with their enhanced binding to highly infectious DC-tethered progeny virions leads to a steadily increasing immune selection pressure on viral virulence in highly C-19 vaccinated populations. This is thought to eventually trigger the selection of a new family of cryptic viral lineages (i.e., ‘cryptic viral quasispecies’) that have the capacity to cause PNNAb-mediated enhancement of VBTIs in highly C-19-vaccinated populations, thereby causing a massive wave of enhanced severe C-19 disease.
More at the link... only posted half of it.
www.voiceforscienceandsolidarity.org
I can now spot the tsunami at the horizon
By Geert Vanden Bossche
Nature will unambiguously demonstrate that neither the unvaccinated nor the vaccinated who refused to re-vaccinate can be blamed for the imminent transition of this immune escape pandemic to its final, hyper-acute phase…
The emergence of cryptic lineages: Another example of how a lack of immunological insight leads to empty prejudices.
People often speculate that if my predictions come true (of which I remain 100% convinced), the unvaccinated will once again be scapegoated for exacerbating the public health damage caused by the virus. However, I firmly believe this won't be the case, as it will become unmistakably clear that cases of enhanced severe Covid-19 (C-19) disease will almost1 exclusively occur among the C-19 vaccinated, leaving healthy unvaccinated individuals unaffected.
However, what is more probable is that public health authorities and self-proclaimed health experts will assert that the pandemic, which they believed was receding, has suddenly surged again due to the growing vaccine hesitancy. Consequently, they may argue that the immune system of people who decline updated C-19 vaccines is at risk of being overwhelmed by the current circulating, highly infectious SARS-CoV-2 (SC-2) variants and that many of them will therefore contract chronic SC-2 infections. As a result, they would persistently shed their own ‘home-made’ variants , so-called ‘cryptic’ lineages2,3 that typically are very peculiar and always contained in one place (i.e., primarily localized where the allegedly chronically infected person resides).
Well, it’s just going to be another significant misinterpretation on their part. This misinterpretation, however, conveniently suits them well as it could absolve them of any guilt (but not in the mind of those who read some of my more recent contributions to this topic4).
I will now explain why this can be considered the final and most significant step in the virus's immune escape strategy, marking the beginning of the end of the immune escape pandemic:
7 Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant - Nature Communications
---
First, as the virus gains the upper hand, the pain worsens for vaccinated hosts. This is because diminished Ag uptake may no longer allow universal pathogen-derived peptides to activate CTL responses, but instead prime CD8+ T cells directed at the self-mimicking universal peptide. Provided sufficient upregulation of MHC molecules, the presentation of promiscuous/ universal microbial T cell (Tc) peptides, sharing sufficient structural homology with certain self-peptides, may lay the foundation for the pathogenesis of autoimmune diseases via a phenomenon termed degeneracy of Ag recognition of TCR (T cell receptor)
recognition8,9,10,11.
The priming of autoreactive T cells can be attributed to cross-reactivity between pathogen-derived and self-antigens (molecular mimicry). The chronic antigenic stimulation of circulating autoreactive T cells directed towards tissue-specific self-antigens, likely underlies the pathogenesis of Long Covid. The
severity of this chronic T cell-mediated autoimmune disease presumably hinges on the extent of virus internalization into APCs and subsequent presentation of universal Tc peptides on cell surface-expressed MHC class I molecules. This suggests that both the prevalence and severity of Long Covid cases are poised to rise alongside the evolution of the virus towards an increasingly narrow range of more transmissible variants causing vaccine breakthrough infections (VBTIs) in highly C-19 vaccinated populations. Since the pathogenesis of Long Covid likely involves the degenerate recognition of a universal self-like Tc peptide12,
it’s not surprising to observe that the occurrence and severity of Long Covid are independent of the patient’s genetic MHC background.
Anticipating that the potent and universal CTL activation (coupled with exhaustion of Ag-specific CD8+ T cells!) will be mitigated due to enhanced adsorption of more infectious variants to DC-tethered virions (see fig. 2), we may witness a surge in T cell-mediated autoimmune diseases replacing the surges of turbo cancers. Given that the onset or exacerbation of Long Covid is likely triggered by re-exposure to circulating virus, the diagnosis of Long Covid often correlates with a positive PCR assay or Ag test. However, correlation does not necessarily imply causation, and there's no evidence to support the notion that the chronicity of this condition stems from persistent viral replication.
Based on the proposed dynamics of the interaction between the virus and population-level immunity, it seems reasonable to attribute the chronicity of this condition to the recall of previously induced Ab responses in previously C-19 vaccinated individuals. Therefore, I would prefer to designate this chronic
disease as vaccine-associated autoimmune disease rather than Long Covid, as the former better underscores the immune pathological nature of this condition and its prevalence among C-19 vaccinees.
Finally, it is crucial to recognize that the days of the JN.1 descendants are numbered. With an increasing trend towards the adsorption of viral particles to URT-resident DCs, the concentration of Ab-virus complexes capable of recalling PNNAbs is declining while activated APCs become potent stimulators of autoreactive CD8+ T cells (see further below) but do not activate foreign-centered CD4+ T helper cells. Consequently, PNNAbs titers gradually become rate-limiting for inhibiting viral trans infection. As a result, highly C-19 vaccinated populations are exerting increasing immune pressure on the 'enhancing' antigenic site within the N-terminal domain of S protein (S-NTD) responsible for binding the PNNAbs13 in highly C- 19 vaccinated populations.
However, due to their misunderstanding of Long Covid's pathogenesis and their ignorance regarding the escalating immune pressure on viral virulence, public health authorities may conveniently attribute the increasing prevalence of Long Covid cases in highly C-19 vaccinated populations to the perceived inadequacy of the population’s coverage rate by updated C-19 vaccines.
Conclusion:
I hope this report unequivocally demonstrates that Long Covid patients are not a persistent source for currently detected highly transmissible lineages or for future highly virulent cryptic lineages. Instead, these patients suffer from immune pathological consequences stemming from SIR-enabling VBTIs within highly C-19 vaccinated populations. SIR-enabling VBTIs, and thus the sporadic and temporary emergence of cryptic SC-2 lineages and the accompanying so-called Long Covid cases, are merely the consequences of escalating immune escape and immune pressure originating from mass vaccination and eventually driving the virus to evolve with remarkable gain-of-function (see fig. 1).
Mass vaccination, rather than the lack of acceptance of updated C-19 vaccinations, is the sole cause of the seemingly perpetual cycle of viral immune escape and the accompanying rise in chronic immune pathology (referred to as ‘Long Covid’). However, the increasing incidence of Long Covid cases, coupled with the evolution of JN.1 descendants towards higher levels of intrinsic infectiousness, serves as the harbinger of a dramatic wave of highly virulent VBTIs that will ultimately put an end to the large-scale gain-of-function experiment conducted in highly C-19 vaccinated populations.
There shall be no doubt that the responsibility of this unprecedented gain-of-function experiment on the very human species solely lies with those who orchestrated this mass vaccination program. Neither patients dealing with Long Covid nor individuals who declined the C-19 vaccination or rejected the updated boosters, can be blamed for the increasing incidence of Long Covid and the looming disaster that could have been prevented if the principle of "First, do no harm" had been honored.
Fig.1: The immune escape pandemic in a nutshell. Large-scale infection-prevention measurescombined with mass C-19 vaccination resulted in large-scale gain-of-function (from asymptomatic-mild infection by Wuhan-Hu-1 lineage to (PNN)Ab-dependentenhancement of severe C-19 disease by HIVICRON).
Fig. 2: Early Omicron descendants enter target host cells via PNNAb-dependent enhancement of infection (1). PNNAbs bind to progeny virus tethered to these DCs, which subsequently migrate to the lungs and other distal organs (2). On the other hand, previously SIR-primed Abs bind with low-affinity to the antigenically more distant immune escape variant, thereby generating Ab-virus complexes that are taken up into patrolling APCs (3). Enhanced uptake of large Ab-virus complexes into APCs facilitates strong activation of CTLs, thereby enabling the elimination of virus-infected host while impeding T help to assist in boosting of previously SIR-primed Abs. Diminished boosting of previously primed anti-S Abs results in diminished production of PNNAbs. Highly infectious Omicron descendants do not rely on PNNAb-dependent enhancement of infection to enter target host cells. Replication of highly infectious variants generates an immunological environment that promotes their adsorption onto tissue-resident DCs. Due to their high level of intrinsic infectiousness, newly emerging, more transmissible Omicron descendants (e.g., members of the JN.1 clan) will therefore enhance the adsorption of progeny virions on migratory DCs and thereby reduce viral uptake by APCs. As these highly infectious variants are steadily growing in prevalence, diminished production of PNNAbs, combined with their enhanced binding to highly infectious DC-tethered progeny virions leads to a steadily increasing immune selection pressure on viral virulence in highly C-19 vaccinated populations. This is thought to eventually trigger the selection of a new family of cryptic viral lineages (i.e., ‘cryptic viral quasispecies’) that have the capacity to cause PNNAb-mediated enhancement of VBTIs in highly C-19-vaccinated populations, thereby causing a massive wave of enhanced severe C-19 disease.
More at the link... only posted half of it.
I can now spot the tsunami at the horizon | Voice for Science and Solidarity
There shall be no doubt that the responsibility of this unprecedented gain-of-function experiment on the very human species solely lies with
www.voiceforscienceandsolidarity.org
I have been busy...not kept up on the thread for while....
went ahead and grabbed this book to add to the bookshelf....it brought to mind a very old book I have...Folk Medicine....New England almanac of natural health care from noted Vermont country doctor...D.C. Jarvis, M.D...copywrite 1958...it may still be in print..he also writes about iodine
have done some reading on various things... and what they are useful for and changed our routine a bit..in the face of the election? this fall...and the possibilities of multiple "things" being released..
In addition to whatever is coming in with the invaders..
We continue to use D3 10,000 IU with K2 and beta carotene.. also Vit C...500 to 1000 per day.. ivermectin (per weight) 3 days on 5 days off... because of the shedding..
Olive leaf extract and beta glucan....
After the reminder I will add Kelp for the iodine..
We continue to research.
Antiviral,
antibiotic,
antifungal,
antiparasitic
and anticancer
Last edited:
jward
passin' thru
Paul Sperry
@paulsperry_
BREAKING: Biden is mandating Americans reentering US give CDC contact tracing info or face "criminal penalties," even though CDC's COVID health emergency expired May 2023. Meantime, WH is meeting with "pandemic experts" over possible "avian influenza" outbreak. Here we go again?
2:38 PM · Apr 2, 2024
39.3K
Views
@paulsperry_
BREAKING: Biden is mandating Americans reentering US give CDC contact tracing info or face "criminal penalties," even though CDC's COVID health emergency expired May 2023. Meantime, WH is meeting with "pandemic experts" over possible "avian influenza" outbreak. Here we go again?
2:38 PM · Apr 2, 2024
39.3K
Views
In October of 2021....I became very ill with a respiratory infection.... was tested not C-19...
It was bacterial.....I was given Z- pack (250 mg)..same as your husband..it slowed it down but didn't kill it....The second round of antibotics was Cefuroxime Axetil..500 mg twice a day for 5 days...I was not tested for the bacteria...the second rx killed if not much improved after 3 days..was to return for lung xray and blood test..
To determine what bacterial..they never said pneumonia..but if it wasn't it was very close..
Interesting Dr Z's protocol calls for azithromycin in the 500 mg strength rather than the 250 mg strength used in the Zpacks...
naegling62
Veteran Member
Geert, Clif and Degal are lining up simultaneously.
Zoner
Veteran Member
links please?
naegling62
Veteran Member
Just an observation from Geert's latest interview and his assertion the deaths will occur quickly even as fast as 24hrs and along with the volume of deaths. Sounds eerily similar to Clif and the Degal report.
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Tristan
Has No Life - Lives on TB
Profit of Doom
Dismember
And how about the invaders? Any contact information from them?
Profit of Doom
Dismember
Like Mars, Jupiter, and Saturn?
Heliobas Disciple
TB Fanatic
I'm going to post two articles from Rintrah (I post from him often lately) on the new strain of bird flu now found in cows because as you will see, he thinks it's related to the vaxx and what it did to immunity (the vaxx exacerbating other main issues that caused this according to his analysis). I will then post three news articles about this strain of bird flu which I think will read differently for you after reading Rintrah's analysis. And finally Thailand Medical News' interpretation. So read all of them together.
~~~~~~~~~~~~~~~~
(fair use applies)
You still have a choice
Radagast
April 2, 2024
So we now have the first case in Texas, of someone who caught bird flu from an infected cow. It infected his eye, which should give you a hint as to how much masks are going to help. This has happened within days of the first cows being infected. By now we have 7 herds in Texas, 2 in Kansas, 1 in Michigan, 1 in New Mexico and 1 in Idaho. The poor cows are an intermediary step, for this abnormally deadly virus that evolves in the chicken concentration camps to jump into humans. Time will tell whether it needs pigs as an intermediary step before the final jump.
But I do know this: Once this thing escalates, there’s no going back. And please realize, you will want to go back and undo what caused this. These bird flu viruses don’t seem to target the lungs in mammals, they mostly seem to damage the brain.
It could be my gut feeling is right and it won’t take more than a few months for this to go horribly wrong. It could also take a few years. But the reality, whether you like it or not, is that you started this yourselves:
This is the problem. You started this war and I don’t get the impression that nature is planning to sit around and let you all kill off the Amazon rain forest in a death spiral of droughts and forest fires that destroy its ability to generate its own clouds.
Half the world’s arable land is directly or indirectly used for meat production. If all that land was released, nature would produce shrubs there, that store and release moisture. Methane concentrations in the atmosphere would begin to reduce within a few years. Carbon dioxide would start to be sequestered. The plants that grow on land no longer used for food production would regulate rainfall, regulate global and local temperatures and sequester carbon.
Don’t be an idiot and show up here insisting that your grassfed beef grazes on natural pastures. We’re above 420 parts per million. The world you remember is gone. Grasslands around the world are supposed to be transitioning to shrubs and forests, to do their job of enabling life to survive.
Look, you just have this ability. Your governments can just decide that enough is enough. You can just start feeding the population the plants that you’re now feeding to the animals in these concentration camps. Soybeans and grain are fed to cattle. Chickens receive grains and even fish from the ocean. This is stuff you can feed to humans. You can also wait of course for Mother Nature to solve the problem. You’ll all insist it was some monstrous conspiracy of course, you’ll go into your grave denying what happened.
But I just don’t get it. Why isn’t there some kind of global emergency program by governments to revamp the food production system and get rid of this reliance on 1200 million tonnes of animals eaten by humans? Do they not realize how late into the game we are, with entire ecosystems being screwed up by man-made superinfluenza viruses jumping from the chickens into wild birds? You literally just have your wild sea bird populations dying out in Scotland now, with wave after wave of avian influenza killing the birds, year after year. Why doesn’t the population recognize how screwed up all of this is?
Why isn’t this something discussed in the news? “Well gee, we found a dead fox with brain damage from bird flu. Well gee, some cows are sick. Well gee, now a man has it.” WHY DON’T THEY TELL YOU HOW WE ENDED UP WITH THESE HYPERVIRULENT INFLUENZA STRAINS? Do these retards think it’s just normal to have entire bird populations die off from influenza? Hey morons, can I just remind you all for a moment of something: You see influenza viruses with polybasic cleavage sites emerge under two conditions: In factory farms and in cell cultures.
Anyway, we have to ask ourselves what happens when the bird flu jumps into the human population. It’s unlikely to be like SARS2, with one single introduction. A single introduction makes it relatively easy to produce a vaccine, because everyone gets roughly the same virus. We’re likely to see numerous strains jump into humans over time. Vaccinating against one strain will then just mean that you’re giving an advantage to the other strains.
Here’s another fun fact: The first jumps into mammal species of these polybasic cleavage site influenza viruses tend to be mild. There is then a very brief period, in which they have to regain their virulence, as they adopt to the new host species. But the polybasic cleavage site (which only evolves under the high densities of the chicken farms, not in nature), ensures that it ends up becoming a virulent virus again.
This polybasic cleavage site is also what allows these viruses to behave very different from regular influenza: It allows this virus to infect your endothelial cells that line all your blood vessels, just like SARS2 does! That’s probably part of the reason these versions of influenza tend to gravitate towards higher virulence: They use different cell types to replicate themselves. So right now the cows getting sick are mostly fine. Give it a few jumps from one cow into another and see if the cows are still fine.
You completely ****ed up the natural balance that exists for these viruses. Influenza is normally mild in birds, because it’s spread by birds that have to fly for days from one place to another. Sick birds will struggle to spread influenza, so mild strains are favored. When humans are the ones moving chickens from one place to another, chickens that spend most of their time inside with other chickens, you screw up this dynamic. You’re also moving cows from one state to another, without checking if they have influenza. And of course you dramatically reduced the genetic diversity of domesticated animals, allowing these viruses to spread very rapidly. The cows in the Western world today are almost all Holstein cows descended from two bulls that lived in the late 19th century. Oh and you decided to vaccinate chickens.
Infections from SARS2 force lymphocytes into the brain. After vaccination, this will be mainly T cells, although some antibodies may help protect their brains too. In the unvaccinated, it will be mainly NK cells. The NK cells should be able to offer some protection against the neurovirulent influenza viruses too. They also have the ability to produce acetylcholine, which helps the brain cope with some of the consequences caused by neurovirulent viruses.
Oh while I’m at it, I can not emphasize this enough. We know what discriminates against virulent influenza strains: NK cells. We just have the evidence for this. They preferentially go after cells infected with the highly pathogenic bird flu. Humans and non-human animals are supposed to spread mild influenza strains, so that these abnormal man-made influenza strains from our factory farms with polybasic cleavage sites fail to grow dominant. But this is failing. The polybasic cleavage site variants of infuenza are growing dominant across the web of life, first the Auschwitz chickens, then wild birds, now our cows, soon Homo not-so-Sapiens.
We can receive a surprise strain of SARS2, against which antibodies suddenly dramatically fail, this is hard to predict. But as I have gone through great lengths to document, the constant stimulation of the adaptive immune response against SARS2 comes at the cost of the generalist innate immune system. That’s why you see various signs of elevated infectious disease in the population. When we have an avian influenza pandemic, you can expect that this problem again reveals itself.
It takes a lot of effort, to create this grand finale. But you pulled it off.
I mean, please be intellectually honest to yourself for a moment. The world is filled with giant concentration camps for genetically identical chickens, that weigh more when put together than all of the world’s wild birds put together. Those chickens were vaccinated with vaccines that bred vaccine-resistant influenza viruses. Those influenza viruses have started killing millions of wild birds worldwide, entire species have had their population reduced by more than half in some countries.
Now it jumped into your cows. The first cases are jumping from cows into humans. Eventually it will jump into pigs, there it gets to recombine with other influenza viruses. How do you see this ending yourself? Why am I the weirdo, for pointing out how screwed up this is? Why does everyone just passively continue going through the motions, stuck together in this giant machine that is clearly marching towards a cliff? Are you all going to beg your government to be locked up at home again, when you realize the machine is falling off a cliff again?
If two years from now, we have a billion people dead from bird flu, a billion dead from starvation and another two billion with severe brain damage, are you really going to tell me that this all comes as a shock to you, instead of recognizing it as a logical consequence of humans distorting the entire balance of life on this planet?
You can just stop breeding cattle, pigs and chickens. You can euthanize the living animals. You can embark on survival mode. Or you can just wait and see how nature goes about solving this stinking mess of course. It’s very strange, to see this kind of situation where different lines of evidence all lead to the same conclusion.
It’s cruel how humans treat chickens, pigs and cows.
It’s dangerous, how it spreads severe influenza viruses around the world.
It’s causing deforestation.
It’s causing climate change.
It’s poisoning the soil in the Netherlands with all the manure.
It’s causing harmful algae blooms.
It’s causing hunger.
It’s causing soil erosion.
So is this really going to continue, until mother nature puts a stop to it?
I just really wish people would tell me: What exactly makes you look at all of this and think to yourself “that will sort itself out”? It just reminds me of Dutch people in 1939, who were completely convinced there was no way we would end up involved in the new world war, because we managed to skip the first one.
But how can you look at this and NOT expect it to go terribly wrong at some point?
~~~~~~~~~~~~~~~~
(fair use applies)
You still have a choice
Radagast
April 2, 2024
So we now have the first case in Texas, of someone who caught bird flu from an infected cow. It infected his eye, which should give you a hint as to how much masks are going to help. This has happened within days of the first cows being infected. By now we have 7 herds in Texas, 2 in Kansas, 1 in Michigan, 1 in New Mexico and 1 in Idaho. The poor cows are an intermediary step, for this abnormally deadly virus that evolves in the chicken concentration camps to jump into humans. Time will tell whether it needs pigs as an intermediary step before the final jump.
But I do know this: Once this thing escalates, there’s no going back. And please realize, you will want to go back and undo what caused this. These bird flu viruses don’t seem to target the lungs in mammals, they mostly seem to damage the brain.
It could be my gut feeling is right and it won’t take more than a few months for this to go horribly wrong. It could also take a few years. But the reality, whether you like it or not, is that you started this yourselves:
This is the problem. You started this war and I don’t get the impression that nature is planning to sit around and let you all kill off the Amazon rain forest in a death spiral of droughts and forest fires that destroy its ability to generate its own clouds.
Half the world’s arable land is directly or indirectly used for meat production. If all that land was released, nature would produce shrubs there, that store and release moisture. Methane concentrations in the atmosphere would begin to reduce within a few years. Carbon dioxide would start to be sequestered. The plants that grow on land no longer used for food production would regulate rainfall, regulate global and local temperatures and sequester carbon.
Don’t be an idiot and show up here insisting that your grassfed beef grazes on natural pastures. We’re above 420 parts per million. The world you remember is gone. Grasslands around the world are supposed to be transitioning to shrubs and forests, to do their job of enabling life to survive.
Look, you just have this ability. Your governments can just decide that enough is enough. You can just start feeding the population the plants that you’re now feeding to the animals in these concentration camps. Soybeans and grain are fed to cattle. Chickens receive grains and even fish from the ocean. This is stuff you can feed to humans. You can also wait of course for Mother Nature to solve the problem. You’ll all insist it was some monstrous conspiracy of course, you’ll go into your grave denying what happened.
But I just don’t get it. Why isn’t there some kind of global emergency program by governments to revamp the food production system and get rid of this reliance on 1200 million tonnes of animals eaten by humans? Do they not realize how late into the game we are, with entire ecosystems being screwed up by man-made superinfluenza viruses jumping from the chickens into wild birds? You literally just have your wild sea bird populations dying out in Scotland now, with wave after wave of avian influenza killing the birds, year after year. Why doesn’t the population recognize how screwed up all of this is?
Why isn’t this something discussed in the news? “Well gee, we found a dead fox with brain damage from bird flu. Well gee, some cows are sick. Well gee, now a man has it.” WHY DON’T THEY TELL YOU HOW WE ENDED UP WITH THESE HYPERVIRULENT INFLUENZA STRAINS? Do these retards think it’s just normal to have entire bird populations die off from influenza? Hey morons, can I just remind you all for a moment of something: You see influenza viruses with polybasic cleavage sites emerge under two conditions: In factory farms and in cell cultures.
Anyway, we have to ask ourselves what happens when the bird flu jumps into the human population. It’s unlikely to be like SARS2, with one single introduction. A single introduction makes it relatively easy to produce a vaccine, because everyone gets roughly the same virus. We’re likely to see numerous strains jump into humans over time. Vaccinating against one strain will then just mean that you’re giving an advantage to the other strains.
Here’s another fun fact: The first jumps into mammal species of these polybasic cleavage site influenza viruses tend to be mild. There is then a very brief period, in which they have to regain their virulence, as they adopt to the new host species. But the polybasic cleavage site (which only evolves under the high densities of the chicken farms, not in nature), ensures that it ends up becoming a virulent virus again.
This polybasic cleavage site is also what allows these viruses to behave very different from regular influenza: It allows this virus to infect your endothelial cells that line all your blood vessels, just like SARS2 does! That’s probably part of the reason these versions of influenza tend to gravitate towards higher virulence: They use different cell types to replicate themselves. So right now the cows getting sick are mostly fine. Give it a few jumps from one cow into another and see if the cows are still fine.
You completely ****ed up the natural balance that exists for these viruses. Influenza is normally mild in birds, because it’s spread by birds that have to fly for days from one place to another. Sick birds will struggle to spread influenza, so mild strains are favored. When humans are the ones moving chickens from one place to another, chickens that spend most of their time inside with other chickens, you screw up this dynamic. You’re also moving cows from one state to another, without checking if they have influenza. And of course you dramatically reduced the genetic diversity of domesticated animals, allowing these viruses to spread very rapidly. The cows in the Western world today are almost all Holstein cows descended from two bulls that lived in the late 19th century. Oh and you decided to vaccinate chickens.
Infections from SARS2 force lymphocytes into the brain. After vaccination, this will be mainly T cells, although some antibodies may help protect their brains too. In the unvaccinated, it will be mainly NK cells. The NK cells should be able to offer some protection against the neurovirulent influenza viruses too. They also have the ability to produce acetylcholine, which helps the brain cope with some of the consequences caused by neurovirulent viruses.
Oh while I’m at it, I can not emphasize this enough. We know what discriminates against virulent influenza strains: NK cells. We just have the evidence for this. They preferentially go after cells infected with the highly pathogenic bird flu. Humans and non-human animals are supposed to spread mild influenza strains, so that these abnormal man-made influenza strains from our factory farms with polybasic cleavage sites fail to grow dominant. But this is failing. The polybasic cleavage site variants of infuenza are growing dominant across the web of life, first the Auschwitz chickens, then wild birds, now our cows, soon Homo not-so-Sapiens.
We can receive a surprise strain of SARS2, against which antibodies suddenly dramatically fail, this is hard to predict. But as I have gone through great lengths to document, the constant stimulation of the adaptive immune response against SARS2 comes at the cost of the generalist innate immune system. That’s why you see various signs of elevated infectious disease in the population. When we have an avian influenza pandemic, you can expect that this problem again reveals itself.
It takes a lot of effort, to create this grand finale. But you pulled it off.
I mean, please be intellectually honest to yourself for a moment. The world is filled with giant concentration camps for genetically identical chickens, that weigh more when put together than all of the world’s wild birds put together. Those chickens were vaccinated with vaccines that bred vaccine-resistant influenza viruses. Those influenza viruses have started killing millions of wild birds worldwide, entire species have had their population reduced by more than half in some countries.
Now it jumped into your cows. The first cases are jumping from cows into humans. Eventually it will jump into pigs, there it gets to recombine with other influenza viruses. How do you see this ending yourself? Why am I the weirdo, for pointing out how screwed up this is? Why does everyone just passively continue going through the motions, stuck together in this giant machine that is clearly marching towards a cliff? Are you all going to beg your government to be locked up at home again, when you realize the machine is falling off a cliff again?
If two years from now, we have a billion people dead from bird flu, a billion dead from starvation and another two billion with severe brain damage, are you really going to tell me that this all comes as a shock to you, instead of recognizing it as a logical consequence of humans distorting the entire balance of life on this planet?
You can just stop breeding cattle, pigs and chickens. You can euthanize the living animals. You can embark on survival mode. Or you can just wait and see how nature goes about solving this stinking mess of course. It’s very strange, to see this kind of situation where different lines of evidence all lead to the same conclusion.
It’s cruel how humans treat chickens, pigs and cows.
It’s dangerous, how it spreads severe influenza viruses around the world.
It’s causing deforestation.
It’s causing climate change.
It’s poisoning the soil in the Netherlands with all the manure.
It’s causing harmful algae blooms.
It’s causing hunger.
It’s causing soil erosion.
So is this really going to continue, until mother nature puts a stop to it?
I just really wish people would tell me: What exactly makes you look at all of this and think to yourself “that will sort itself out”? It just reminds me of Dutch people in 1939, who were completely convinced there was no way we would end up involved in the new world war, because we managed to skip the first one.
But how can you look at this and NOT expect it to go terribly wrong at some point?
Last edited:
Heliobas Disciple
TB Fanatic
(fair use applies)
Cross-reactive natural immunity between bird flu and SARS2
Radagast
April 3, 2024
So, as we see the first cases emerge of humans infected with bird flu, with mammals as an intermediary step, you may have found yourself wondering how the experience of the past four years will impact this development. Are people better prepared for the eventual jump into our species, thanks to our SARS2 experience? Or are we merely worse off, with immune systems that have been damaged?
To answer that question, we first have to look at what these two viruses have in common. Both are single-stranded RNA respiratory viruses. Both viruses have also developed a polybasic cleavage site, that allows them to infect endothelial cells (the cells lining your blood vessels), which they would normally not be able to do.
“Polybasic cleavage site” means these two viruses have a site right in the place where they bind to receptors (doors on our cells used to enter), that is composed of multiple basic (the opposite of acidic) amino acids (the building blocks of proteins). Such a site can attract enzymes, that have the effect of cutting the protein up into the right sized bits that allow it to do its job and take over the cell. This is why these polybasic cleavage sites often show the effect of allowing a virus to take over cell types it could otherwise not infect.
Under normal conditions in nature, such polybasic cleavage sites do not evolve, at least not in influenza. They look weird to the immune system, unlikely any chain of amino acids your own proteins contain. Birds that were infected by influenza with such a site and managed to survive it would be expected to develop antibodies that concentrate on this weird polybasic cleavage site (although such antibodies are insufficient on their own to prevent infection). As a result, they can still catch and transmit influenza, but they will be less likely to transmit influenza with a polybasic cleavage site anymore.
In nature, geese live for multiple decades, traveling around the world, getting infected by influenza, spreading influenza, developing immunity against it, then getting reinfected by other influenza strains that look different and transmitting those. In our chicken farms, the average life expectancy of a chicken is 42 days. In other words, our birds can not discriminate against these very deadly strains of influenza, as they die before they ever get reinfected.
Older wild birds on the other hand make sure that influenza stays a mild virus, both for their own species, as well as for mammals like humans. Our own elderly did the same job for us after the 1918 pandemic. They lived out the rest of their lives, with antibodies that specifically prohibit the 1918 virus from spreading, without really stopping other influenza viruses from spreading. Unfortunately for us, those elderly who had such excellent immunity have died by now.
Your body has a wide range of different tools that it uses to protect itself from viruses. The big divide is between adaptive immunity (which includes the antibodies) and innate immunity. With inactivated vaccines, not based on a live virus capable of actually infecting cells, we mainly stimulate adaptive immunity. This has resulted in the situation in which people who were vaccinated against SARS-COV-2, rely more on antibodies to deal with future infections from that virus, than people who were not vaccinated against it. You can see this difference reveal itself whenever you compare vaccinated and unvaccinated people’s response to new strains of that virus.
Here you see antibodies in unvaccinated adults against SARS2:
Here you can see the response in vaccinated adults, who received two shots of mRNA:
You can see that vaccinated adults have some neutralizing antibodies that are on stand-by against the virus, that also bind to the newest versions of the virus. The adaptive immune system has simply taken on a bigger role in preventing reinfections in vaccinated people, than it has in unvaccinated people.
Natural immunity against SARS2 is not a free lunch, it would be dishonest for me to argue that. What I have always argued instead, is that it results in a better outcome for people in the long run, that is, over a period of multiple years. It means that endothelial cells will be infected. This means surrounding endothelial cells will respond by going on high alert, along with the infected endothelial cells (if they survive it). Studies suggest an increased risk of cardiovascular events after a SARS2 infection, particularly among the unvaccinated. That risk is of course concentrated among people who already had poor cardiovascular health.
But what I have always said, is that humans settled on deploying the wrong tool for the job, which will reveal its impact in the long run. They are forcing people’s bodies, to deploy a lot of adaptive immune capacity, against a single respiratory virus. This comes at the cost of their lungs ability to deal with other respiratory viruses. That’s why you can see a gradual rise in respiratory problems in the Dutch population, as growing numbers of people go to their doctor, complaining of a cough that just won’t go away:
Whether we will see a sudden unexpected failure of the adaptive immune response against SARS2, because of a sudden mutation to the virus, is something that is hard to predict. I have explained some mechanisms through which this could suddenly happen here.
But I want to answer instead, what this experience will mean for the eventual bird flu pandemic our species will have to face.
It has been known for a long time, that exposure to unrelated respiratory viruses, can help dampen influenza pandemics. The 1918 influenza pandemic had the worst impact on isolated islands in the Pacific. Whereas on Hawaii just 0.4% of the population died, on Samoa 22% died.
In the above image you can see why this is. Alveolar macrophages are altered by the experience, memory NK cells establish themselves in the lungs (which I have told you about many times before). On the other hand, in isolated communities, a whole bunch of influenza specific T-cells are deployed against the 1918 flu, that suddenly trigger a very aggressive immune response, damaging the lungs and thereby allowing bacteria to join the party too.
The body does not depend on T cells and B cells, to learn from previous respiratory infections. There are also alterations to lymphatic and vascular tissues. Tissues that were under severe stress in a previous infection, will have alterations that help them cope with future infections, similar to how muscles under stress during exercise get better vascular system to help them cope with future exercise.
Some people tell you that your body does not learn from viral infections. Those people are wrong.
The endothelial cells that are infected by both SARS2 and by bird flu, can effectively be thought of as immune cells in their own right. They are equipped with a wide range of innate immune tools. When they are infected by an RNA virus, they will learn to produce the sort of receptors within the cell, that allows a cell to check whether there’s a big chunk of strange RNA and deletes that RNA when necessary. These responses are recalled more rapidly next time they’re dealing with a virus.
Most important of all perhaps are the NK cells, that have migrated into the tissues where SARS2 showed up, at least in people who were infected before ever being vaccinated against SARS2. Those NK cells have receptors that allow them to recognize whether a cell is sick or healthy. They use those receptors, in combination with specific receptors that recognize the sort of proteins covered in sugar molecules, that viruses use to enter cells. Importantly, we know that the exact same receptors the NK cells use for influenza, are the ones they use for SARS2: NKp44 and NKp46 among others.
When NK cells see the same virus again in a cell, they are less aggressive against it: They prefer to release interferon Gamma, to let the cell solve it on its own, rather than killing the cell. On the other hand, when they see a different virus in a cell, they tend to be cautious again and kill the cell. This makes perfect sense of course, when you think about it.
Unfortunately, this has to be contrasted with adaptive immunity. The antibodies produced by the B cells and plasma cells in response to SARS2, are useful against SARS2. Some of those antibodies may bind to influenza too, but they’re not going to be very useful against it. Often they bind to a place on SARS2 that neutralizes the virus, but bind to a place on influenza where it doesn’t neutralize influenza. To make matters worse, these antibodies can then prevent the immune system from deploying a response against influenza that does work. They can even prevent an NK cell from recognizing what’s going on.
This matters a lot, because whereas most people are vaccinated against measles or polio and then never encounter these viruses during their lives, people who were vaccinated against SARS2 are constantly getting infected by different versions of SARS2, that force more and more T cells and B cells to populate their tissues to focus on this particular virus. This adaptive immune response interferes in the response to unrelated viruses, like Dengue.
For SARS2 to overcome the adaptive immune response induced by these vaccines, it needs a lucky monster: A strain that is radically different from the currently circulating strains. It’s hard to predict when and if that will happen, but it can happen very suddenly.
Unfortunately, for bird flu that’s just not true. Once it jumps into our species, it will inherently look very different, most of the T cells and B cells people’s bodies deployed against SARS2 will be of little use to it. Rather, they will be interfering in developing a proper response to bird flu.
If bird flu could immediately jump from birds into humans and spread through our species, we would have probably already seen that happen by now. Instead, it seems that it first needs to use another mammal, as an intermediary state before the big jump.
I’m not a genius with a crystal ball, I can’t tell you whether we’ll have bird flu pandemic a month from now, a year from now or a decade from now. But I can read studies. Those studies very clearly demonstrate: Natural infections with unrelated respiratory pathogens protect people against severe influenza viruses.
In contrast, an adaptive immune response, induced by multiple breakthrough infections after vaccination with inactive vaccines against a particular respiratory infection, has no such effect. Rather, it increases vulnerability to unrelated pathogens. People’s lungs are now filled with T cells and B cells, that are trying desperately to keep out SARS2.
That’s not my theory. It’s not Geert van den Bossche’s theory either. It’s simply what humanity knows, from the numerous studies that have been done on this subject.
We live in the pandemic era. That’s the logical consequence, of a number of things:
-Climate change forcing animals in contact that would normally never meet each other.
-Human overpopulation.
-Many millions of immunocompromised people kept alive with various therapies.
-Humans traveling around the world in airplanes, that can put you from London in Brazzaville within hours, a journey that would take our ancestors weeks.
-Human factory farms, full of inbred animals.
-The stupid decision to vaccinate the chickens in the factory farms against influenza.
Vaccinating people of all age categories with these inactivated vaccines, against a respiratory virus (SARS2) that killed less than 1% of people it infected, almost all elderly in poor health, is a luxury humanity could not afford. Yet they decided to do it anyway.
It did not work, it caused constant reinfections with waves of more infectious variants of the virus. The fortunate side-effect of that, is that unvaccinated people in good health have built up competent immunity that will help protect them against the bird flu pandemic.
We spent our ammunition on the wrong bug. We went into the woods at night and emptied our gun on a wolf, not realizing the bear approaching us from the back.
Cross-reactive natural immunity between bird flu and SARS2
Radagast
April 3, 2024
So, as we see the first cases emerge of humans infected with bird flu, with mammals as an intermediary step, you may have found yourself wondering how the experience of the past four years will impact this development. Are people better prepared for the eventual jump into our species, thanks to our SARS2 experience? Or are we merely worse off, with immune systems that have been damaged?
To answer that question, we first have to look at what these two viruses have in common. Both are single-stranded RNA respiratory viruses. Both viruses have also developed a polybasic cleavage site, that allows them to infect endothelial cells (the cells lining your blood vessels), which they would normally not be able to do.
“Polybasic cleavage site” means these two viruses have a site right in the place where they bind to receptors (doors on our cells used to enter), that is composed of multiple basic (the opposite of acidic) amino acids (the building blocks of proteins). Such a site can attract enzymes, that have the effect of cutting the protein up into the right sized bits that allow it to do its job and take over the cell. This is why these polybasic cleavage sites often show the effect of allowing a virus to take over cell types it could otherwise not infect.
Under normal conditions in nature, such polybasic cleavage sites do not evolve, at least not in influenza. They look weird to the immune system, unlikely any chain of amino acids your own proteins contain. Birds that were infected by influenza with such a site and managed to survive it would be expected to develop antibodies that concentrate on this weird polybasic cleavage site (although such antibodies are insufficient on their own to prevent infection). As a result, they can still catch and transmit influenza, but they will be less likely to transmit influenza with a polybasic cleavage site anymore.
In nature, geese live for multiple decades, traveling around the world, getting infected by influenza, spreading influenza, developing immunity against it, then getting reinfected by other influenza strains that look different and transmitting those. In our chicken farms, the average life expectancy of a chicken is 42 days. In other words, our birds can not discriminate against these very deadly strains of influenza, as they die before they ever get reinfected.
Older wild birds on the other hand make sure that influenza stays a mild virus, both for their own species, as well as for mammals like humans. Our own elderly did the same job for us after the 1918 pandemic. They lived out the rest of their lives, with antibodies that specifically prohibit the 1918 virus from spreading, without really stopping other influenza viruses from spreading. Unfortunately for us, those elderly who had such excellent immunity have died by now.
Your body has a wide range of different tools that it uses to protect itself from viruses. The big divide is between adaptive immunity (which includes the antibodies) and innate immunity. With inactivated vaccines, not based on a live virus capable of actually infecting cells, we mainly stimulate adaptive immunity. This has resulted in the situation in which people who were vaccinated against SARS-COV-2, rely more on antibodies to deal with future infections from that virus, than people who were not vaccinated against it. You can see this difference reveal itself whenever you compare vaccinated and unvaccinated people’s response to new strains of that virus.
Here you see antibodies in unvaccinated adults against SARS2:
Here you can see the response in vaccinated adults, who received two shots of mRNA:
You can see that vaccinated adults have some neutralizing antibodies that are on stand-by against the virus, that also bind to the newest versions of the virus. The adaptive immune system has simply taken on a bigger role in preventing reinfections in vaccinated people, than it has in unvaccinated people.
Natural immunity against SARS2 is not a free lunch, it would be dishonest for me to argue that. What I have always argued instead, is that it results in a better outcome for people in the long run, that is, over a period of multiple years. It means that endothelial cells will be infected. This means surrounding endothelial cells will respond by going on high alert, along with the infected endothelial cells (if they survive it). Studies suggest an increased risk of cardiovascular events after a SARS2 infection, particularly among the unvaccinated. That risk is of course concentrated among people who already had poor cardiovascular health.
But what I have always said, is that humans settled on deploying the wrong tool for the job, which will reveal its impact in the long run. They are forcing people’s bodies, to deploy a lot of adaptive immune capacity, against a single respiratory virus. This comes at the cost of their lungs ability to deal with other respiratory viruses. That’s why you can see a gradual rise in respiratory problems in the Dutch population, as growing numbers of people go to their doctor, complaining of a cough that just won’t go away:
Whether we will see a sudden unexpected failure of the adaptive immune response against SARS2, because of a sudden mutation to the virus, is something that is hard to predict. I have explained some mechanisms through which this could suddenly happen here.
But I want to answer instead, what this experience will mean for the eventual bird flu pandemic our species will have to face.
It has been known for a long time, that exposure to unrelated respiratory viruses, can help dampen influenza pandemics. The 1918 influenza pandemic had the worst impact on isolated islands in the Pacific. Whereas on Hawaii just 0.4% of the population died, on Samoa 22% died.
In the above image you can see why this is. Alveolar macrophages are altered by the experience, memory NK cells establish themselves in the lungs (which I have told you about many times before). On the other hand, in isolated communities, a whole bunch of influenza specific T-cells are deployed against the 1918 flu, that suddenly trigger a very aggressive immune response, damaging the lungs and thereby allowing bacteria to join the party too.
The body does not depend on T cells and B cells, to learn from previous respiratory infections. There are also alterations to lymphatic and vascular tissues. Tissues that were under severe stress in a previous infection, will have alterations that help them cope with future infections, similar to how muscles under stress during exercise get better vascular system to help them cope with future exercise.
Some people tell you that your body does not learn from viral infections. Those people are wrong.
The endothelial cells that are infected by both SARS2 and by bird flu, can effectively be thought of as immune cells in their own right. They are equipped with a wide range of innate immune tools. When they are infected by an RNA virus, they will learn to produce the sort of receptors within the cell, that allows a cell to check whether there’s a big chunk of strange RNA and deletes that RNA when necessary. These responses are recalled more rapidly next time they’re dealing with a virus.
Most important of all perhaps are the NK cells, that have migrated into the tissues where SARS2 showed up, at least in people who were infected before ever being vaccinated against SARS2. Those NK cells have receptors that allow them to recognize whether a cell is sick or healthy. They use those receptors, in combination with specific receptors that recognize the sort of proteins covered in sugar molecules, that viruses use to enter cells. Importantly, we know that the exact same receptors the NK cells use for influenza, are the ones they use for SARS2: NKp44 and NKp46 among others.
When NK cells see the same virus again in a cell, they are less aggressive against it: They prefer to release interferon Gamma, to let the cell solve it on its own, rather than killing the cell. On the other hand, when they see a different virus in a cell, they tend to be cautious again and kill the cell. This makes perfect sense of course, when you think about it.
Unfortunately, this has to be contrasted with adaptive immunity. The antibodies produced by the B cells and plasma cells in response to SARS2, are useful against SARS2. Some of those antibodies may bind to influenza too, but they’re not going to be very useful against it. Often they bind to a place on SARS2 that neutralizes the virus, but bind to a place on influenza where it doesn’t neutralize influenza. To make matters worse, these antibodies can then prevent the immune system from deploying a response against influenza that does work. They can even prevent an NK cell from recognizing what’s going on.
This matters a lot, because whereas most people are vaccinated against measles or polio and then never encounter these viruses during their lives, people who were vaccinated against SARS2 are constantly getting infected by different versions of SARS2, that force more and more T cells and B cells to populate their tissues to focus on this particular virus. This adaptive immune response interferes in the response to unrelated viruses, like Dengue.
For SARS2 to overcome the adaptive immune response induced by these vaccines, it needs a lucky monster: A strain that is radically different from the currently circulating strains. It’s hard to predict when and if that will happen, but it can happen very suddenly.
Unfortunately, for bird flu that’s just not true. Once it jumps into our species, it will inherently look very different, most of the T cells and B cells people’s bodies deployed against SARS2 will be of little use to it. Rather, they will be interfering in developing a proper response to bird flu.
If bird flu could immediately jump from birds into humans and spread through our species, we would have probably already seen that happen by now. Instead, it seems that it first needs to use another mammal, as an intermediary state before the big jump.
I’m not a genius with a crystal ball, I can’t tell you whether we’ll have bird flu pandemic a month from now, a year from now or a decade from now. But I can read studies. Those studies very clearly demonstrate: Natural infections with unrelated respiratory pathogens protect people against severe influenza viruses.
In contrast, an adaptive immune response, induced by multiple breakthrough infections after vaccination with inactive vaccines against a particular respiratory infection, has no such effect. Rather, it increases vulnerability to unrelated pathogens. People’s lungs are now filled with T cells and B cells, that are trying desperately to keep out SARS2.
That’s not my theory. It’s not Geert van den Bossche’s theory either. It’s simply what humanity knows, from the numerous studies that have been done on this subject.
We live in the pandemic era. That’s the logical consequence, of a number of things:
-Climate change forcing animals in contact that would normally never meet each other.
-Human overpopulation.
-Many millions of immunocompromised people kept alive with various therapies.
-Humans traveling around the world in airplanes, that can put you from London in Brazzaville within hours, a journey that would take our ancestors weeks.
-Human factory farms, full of inbred animals.
-The stupid decision to vaccinate the chickens in the factory farms against influenza.
Vaccinating people of all age categories with these inactivated vaccines, against a respiratory virus (SARS2) that killed less than 1% of people it infected, almost all elderly in poor health, is a luxury humanity could not afford. Yet they decided to do it anyway.
It did not work, it caused constant reinfections with waves of more infectious variants of the virus. The fortunate side-effect of that, is that unvaccinated people in good health have built up competent immunity that will help protect them against the bird flu pandemic.
We spent our ammunition on the wrong bug. We went into the woods at night and emptied our gun on a wolf, not realizing the bear approaching us from the back.
Heliobas Disciple
TB Fanatic
Bird flu that infected Texan HAS mutated to spread more easily, CDC
The CDC said tests on the H5N1 sample showed it had a mutation that was 'known to be associated with viral adaptation to mammalian hosts'.
Bird flu that infected Texas farm worker HAS mutated to spread more easily, CDC reveals - as three pet CATS die from virus and America's biggest egg producer is hit with outbreak
By Luke Andrews Senior Health Reporter For Dailymail.Com
Published: 09:19 EDT, 3 April 2024 | Updated: 11:23 EDT, 3 April 2024
- Testing by CDC revealed the virus may have mutated in the Texas patient to better spread in mammals
- Experts are also warning over infections detected in three pet cats which died from the disease
The strain of bird flu that infected a person in Texas has mutated to spread more easily, officials say — amid growing alarm the disease could spread to more people.
The CDC said tests on the H5N1 sample showed it had a mutation that was 'known to be associated with viral adaptation to mammalian hosts' - but insisted the mutations were minor and the overall risk to the public was low.
This mutation was not detected in cattle or in wild birds, with officials saying it 'may have been acquired in the patient during the development of the [eye infection]'.
Meanwhile, three pet cats have died from bird flu after catching the disease on dairy farms in Texas, according to reports — as fears are raised that infected animals living near humans could spread the disease to people.
And the largest egg producer in the US has revealed bird flu has been detected in its flock, with nearly 2million chickens now set to be culled. There is growing concern that the outbreak on farms could cause supply chain issues or drive up the price of eggs and dairy products.
It comes amid concerns that H5N1 — which has already triggered a pandemic in the animal world — could soon do the same in humans. The EU's Food Safety Agency (EFSA) warned Wednesday that a large-scale bird flu pandemic could be triggered if the virus becomes transmissible between people.
nfectious disease experts warn every infection in mammals or humans raises the risk of the virus gaining new mutations enabling it to infect people.
Dr Francois Balloux, an epidemiologist in the UK, warned on X that the situation 'might change for the worse, eventually'.
But he added: 'People not professionally involved in pandemic prevention/mitigation being worried/feeling miserable now won't make any material difference to what may hit us, except that their life would suck, far more than it should.'
Dr Peter Hotez, a virologist at Baylor College of Medicine in Texas, told DailyMail.com that the cases were 'a reminder that avian influenza is circulating and continuously jumping to new mammalian hosts.
'So far, the subsequent jumps to humans are still uncommon and not producing severe illness,' he added, 'but I believe this could change eventually'.
The mutation detected on the virus infecting a dairy farm worker in Texas has been recorded previously, the CDC said — and did not spark a major outbreak at that time.
The change, on the PB2 gene linked to how the virus makes copies of itself, has not been recorded on wild poultry on in infections in cows.
The CDC said: 'It is important to note that this substitution has not been seen in available PB2 genes from viruses circulating in wild birds and poultry or in the recently described cattle viruses detected in Texas.
'[This suggests that] the mutation may have been acquired in the patient during the development of conjunctivitis.'
Bird flu makes millions of copies of itself within every cell it infects before bursting out to infect other nearby cells. A number of these copies contain mutations, with every new copy raising the risk of a mutation emerging which could help the virus to infect or spread between humans.
The patient in Texas had a mild infection, with their only symptom being inflammation of the eye.
The first case of bird flu in the US reported in 2022 in a prison worker also saw the patient suffer only from fatigue for a few days.
There are also concerns over infections with bird flu detected in pets — which raises the risk of the virus being spread to humans.
Yesterday, three pet cats were reported to have died after being infected with the virus on an affected dairy farm in Texas.
So far, seven dairy farms in Texas have reported outbreaks alongside two in Kansas and one each in New Mexico and Michigan. There are also suspicions over another outbreak at a farm in Ames, Iowa.
Cows infected are reported to be 'lethargic', eating less food and producing less milk than previously — although they are not dying from the disease.
At the same time, more outbreaks are being reported at poultry farms — leaving farmers with no option but to cull their birds.
The largest egg producer in the US — Cal-Maine — revealed yesterday it would need to cull 2million birds after the virus was detected in its flock.
Officials in Michigan are now also urging people to take enhanced measures to protect their flocks.
This is raising concerns over rising prices of milk and eggs.
Farmers are being required to dispose of milk from infected animals, while egg producers are knocked out of action for months by the culling of their flocks.
In 2022, egg prices surged more than 50 percent in response to the outbreak — with a dozen large, Grade A eggs, priced at $3.59 in November compared to $1.72 at the same time the year earlier. They peaked in January, 2023, at $4.82 for a dozen eggs.
Bird flu started to take off in 2020 after a wild bird flu swapped genes with a version of the virus from domestic poultry.
It spread rapidly via migrating birds and in May 2021 it was confirmed to have crossed the bird-mammal barrier for the first time — after two baby foxes in the Netherlands tested positive for the disease.
One died from the infection, while the other was euthanized because of its symptoms. The route of infection was not confirmed, but scientists said it was likely via eating the carcass of an infected bird.
In January 2022, the first case was then diagnosed in a human — in 79-year-old Alan Gosling from the UK.
The former engineer had contracted the virus from one of the 20 Muscovy ducks he shared his home with — and had only mild symptoms.
Barely three months later a second human case was reported in a prison inmate working on a poultry farm in Colorado.
The patient also suffered from only mild symptoms — 'fatigue for a few days' — and later recovered after taking the antiviral drug oseltamivir.
In November 2022, China recorded the first death from the virus — in a poultry farm worker who was infected with H5N1.
Sporadic cases have been detected since, but experts say the numbers are still much lower than the outbreak in Egypt around 2015 — when more than a hundred cases were detected.
Bird flu began to spread to domestic birds in February 2022, when the US revealed it had detected H5N1 in a turkey flock.
In that year alone, an estimated 52million birds had to be culled to stop the virus spreading — sending up the price of eggs and chicken meat.
More culling was done in 2023 and again this year, with the total number of culled birds now estimated to be more than 82million.
There are also concerns that the virus could spread into other animals with closer contact with humans after a dog in Ottawa, Canada, tested positive in April 2023.
And there are signs that it is gaining the ability to spread between mammals including seals, after 17,000 pups died at a colony in Patagonia.
Experts said at the time that the animals had been infected with bird flu, and warned that it was likely spreading between animals at the site.
The above graph shows human cases of avian influenza globally reported by year. The colors represent different countries with the light blue being Egypt and the orange being Cambodia
Heliobas Disciple
TB Fanatic
'This could be 100 times worse than Covid': Bird flu warning
Speaking at a briefing, virus researchers in the US said the H5N1 strain of bird flu may now be getting 'dangerously close' to triggering a pandemic. Pharma industry consultant warned of risks.
'This could be 100 times worse than Covid': Bird flu warning from scientists who say HALF of infections with H5N1 in people are fatal - as White House says it's 'monitoring' the situation
By Luke Andrews Senior Health Reporter For Dailymail.Com
Published: 16:38 EDT, 3 April 2024 | Updated: 18:55 EDT, 3 April 2024
- Experts warn there is a higher risk of bird flu starting to spread between humans
- But some appeal for calm, saying there are still a lot of unknowns
A bird flu pandemic could be '100 times worse than Covid' and kill up to half of everyone it infects, experts have warned — as the White House says it is 'monitoring' the situation.
Speaking at a briefing, virus researchers said the H5N1 strain of bird flu may now be getting 'dangerously close' to triggering a pandemic.
Multiple cases of the infection in a variety of mammals, including cows, cats and, more recently, humans, are all raising the risk of the virus mutating to become more transmissible, they said.
But others attending the briefing said it was too early to panic because there were still too many unknowns about recent cases to warrant sounding the alarm.
A White House representative said today it was tracking bird flu in the US, adding: 'We take the health and safety of the American people seriously.'
The above shows how bird flu is edging closer to human spillover in the US
The panel was quickly convened off the heels of news that a dairy farm worker in Texas tested positive for the virus, alongside 12 herds of cows in six states and three cats also in Texas that subsequently died.
Testing done on the worker showed the patient's virus had already mutated to spread more easily — although the CDC said this mutation had been recorded before, that the risk was low and that there was no sign of human-to-human transmission.
The briefing was attended by bird flu researchers, doctors and officials from government agencies who were alarmed by the bird flu case in a human.
John Fulton, a pharmaceutical industry consultant for vaccines and founder of Canada-based pharmaceutical company BioNiagara, organized the meeting after receiving enquiries from the media.
Speaking at the briefing, Dr Suresh Kuchipudi, a bird flu researcher in Pittsburgh, warned: 'This virus [has been] on the top of the pandemic list for many, many years and probably decades.
'And now we are getting dangerously close to this virus potentially causing a pandemic.'
He added: 'H5N1 viruses have already demonstrated several important features of a potential pandemic virus.
'So these are, the virus is already globally distributed, and this virus particularly, that is often perceived as an avian virus, it can, and it has shown, the ability to infect a range of mammalian hosts including humans.
'We are not really talking about a virus that is yet to make a jump, we are talking about a virus that is globally present, already infecting a range of mammals and is circulating.
'So, therefore, in my view, I think this is a virus that has the greatest pandemic threat [that is] playing out in plain sight and is globally present.'
'It is really high time that we are prepared.'
His concerns were echoed by Fulton, who warned the H5N1 strain of influenza A could trigger a worse pandemic than Covid.
He said: 'This appears to be 100 times worse than Covid, or it could be if it mutates and maintains its high case fatality rate.
'Once it’s mutated to infect humans, we can only hope that the [fatality rate] drops.'
The World Health Organization estimates the fatality rate for H5N1 at 52 percent, based on the 462 deaths recorded since 2003 among the 887 people diagnosed with the virus.
For comparison, Covid currently kills less than 0.1 percent of people it infects — although at the beginning of the pandemic this was around 20 percent.
Since 2020, when the new strain of bird flu emerged and spread around the world, seven out of 26 people infected with H5N1 have died — or nearly 30 percent.
Some experts warn that in more serious but rare cases, H5N1 could infect the respiratory tract triggering pneumonia. It can also infect other areas, such as the eyes — where it causes inflammation.
Dr Gabriel Girouard, a microbiologist in New Brunswick, warned the death rate of H5N1 was currently around 50 percent, although there were few human cases.
But he said that if the virus did start to spread between people this would likely 'drop' but still 'remain high'.
Newer infectious diseases have high fatality rates because people do not yet have a defense against them, allowing the virus to evade the immune system and cause a more severe infection.
Other experts attending the panel called for calm, however, including David Swayne, who has worked on bird flu infections in animals for decades.
He said: 'Right now, for the cattle cases — there is no knowledge, so that's easy for the alarm to be raised.
'There is a huge lack of knowledge that we need to fill.
'Let's look at the facts and look at them with reason, we don't really know that much today because of the knowledge gaps that we need to fill.'
Dr Francois Balloux, an epidemiologist in the UK, added on X this morning: 'People not professionally involved in pandemic prevention/mitigation being worried/feeling miserable now won't make any material difference to what may hit us, except that their life would suck, far more than it should.'
To become a pandemic, a virus needs to be able to infect humans or animals easily and spread between them.
But researchers are yet to establish whether the virus is now able to spread from mammal-to-mammal — with studies underway on infected cattle.
The White House press secretary said today, when asked about the US bird flu outbreak: 'This is something we are certainly monitoring.
'We have been, the CDC has been working and focusing on this.
'We take the health and safety of the American people seriously. It is very important to this President. Our top priority is to keep communities healthy, safe and informed.'
So far, 12 farms across six states have reported H5N1 infections in their cows — including five in Texas, as well as farms in New Mexico, Michigan, Ohio, Idaho and Kansas. Cows in Iowa are also being tested.
Infected cattle are described as 'lethargic', eating less food and producing less milk. But they are not dying from their infections.
But it is not clear how the cows became infected, whether it was via exposure to infected droppings, bird carcasses or another route.
It also is not clear whether the virus is spreading between the animals or if they are being infected by a single source, such as their feed. Most of the cases across the country have been linked back to farms in Texas.
For the human case, there are also many unknowns — including how the patient was infected.
It could have been from direct contact with cows or from touching a surface contaminated with the virus and then touching their face.
Although many mammals are being infected, experts say there is one species they focus on in particular: Pigs.
These animals have the same receptors in their lungs as humans, meaning an outbreak among them could predict a similar episode in humans.
But, infections are not currently being recorded in pigs.
However, a person in Pennsylvania was diagnosed with a flu infection from pigs earlier this year and hospitalized, but they made a full recovery. The individual had close contact with pigs and was infected with the H1N2 strain of influenza A, slightly different from H5N1.
Scientists warn pigs could also become infected with human and avian flu viruses at the same time, which could then swap genes — in a process called reassortment — to create a new version of the virus.
The situation has a potential wider impact than just causing panic, however, with the price of milk and eggs also likely to rise.
Milk from infected cows cannot be sold, while egg farms have to cull all their birds when bird flu is detected — which takes months to recover from.
This was behind the surge in egg prices in 2020, when the price of a dozen large, Grade A, eggs surged from $1.72 to $3.59 over the year to November 2022.
At their peak, they reached $4.82 for a dozen eggs.
Officials say there is a very low risk from of contracting bird flu from milk because nearly all the supply is pasteurized, which inactivates viruses and bacteria before milk heads to stores.
Bird flu started to take off in 2020 after a wild bird flu MIXED genes with a version of the virus from domestic poultry.
It spread rapidly via migrating birds and in May 2021 it was confirmed to have crossed the bird-mammal barrier for the first time — after two baby foxes in the Netherlands tested positive for the disease.
One died from the infection, while the other was euthanized because of its symptoms. The route of infection was not confirmed, but scientists said it was likely via eating the carcass of an infected bird.
In January 2022, the first case was then diagnosed in a human — in 79-year-old Alan Gosling from the UK.
Heliobas Disciple
TB Fanatic
Does the H5N1 case in Texas raise the risk of a future pandemic?
While there is no sign of person-to-person spread - a development that would signal the start of a human epidemic - experts say the ease with which the strain is jumping between species raise the risk of it evolving to infect us more easily.
'It's a matter of when, not if': DailyMail.com asked seven bird flu experts if the H5N1 case in Texas raises risk of a future pandemic... this is what they said
By Luke Andrews Senior Health Reporter For Dailymail.Com
Published: 16:13 EDT, 2 April 2024 | Updated: 16:34 EDT, 2 April 2024
- Bird flu infections in mammals raise the risk of dangerous mutations in virus
- Experts suggest is a matter of 'when, not if' for the next human bird flu outbreak
News that a Texan had been infected with H5N1 bird flu on Monday added a worrying wrinkle to a global outbreak that is edging closer to humans.
The patient was a dairy farmer and caught the virus from an infected cow, making them the second American to be infected after a person in Colorado in 2022.
While there is no sign of person-to-person spread — a development that would signal the start of a human epidemic — experts say the ease with which the strain is jumping between species raise the risk of it evolving to infect us more easily.
This variant of H5N1 has been detected in almost every corner of the globe, from the barren Antarctic to the depths of the ocean, since emerging in 2020. But it is the developments that are a little closer to home that are causing concern.
It has been in US poultry farms for years, goats and now cows (not to mention a pet dog in Canada). DailyMail.com spoke to seven infectious disease experts and virologists who have been tracking bird flu H5N1 for years about what the development in Texas means.
Dr Aaron Glatt, an infectious diseases expert at Mount Sinai, New York, warned: 'It is absolutely true that H5N1 has the potential to cause a pandemic.
'People who work with these animals do need to be careful.
'The more that this virus is spread, the more likely it is that it could become a strain that could mutate and start to spread from human-to-human.'
The H5N1 spreading across the world emerged in 2020 after a bird was infected with both a bird flu from domestic poultry and a virus from wild birds.
During the infection, the two viruses met in the same cell and swapped genes — in a process scientifically termed re-assortment — to create the new virus that now had multiple attributes which made it better at infecting bird cells.
It quickly spread globally, with the first cases identified in Europe — before infections also being detected in Africa, the Middle East and Asia.
Dr Leonard Mermel, an infectious diseases expert at Brown University, in Rhode Island, said the fact the disease was spreading in mammals 'raised the risk' of the virus evolving to infect humans.
'Viruses have multiple mutations in every replication cycle [each time they make copies of themselves],' he said.
'Each time that process occurs, where the viruses replicate, there may be many, many mutated viruses that leave [an infected] cell to infect other cells.
'One could, by chance, have a mutation allowing it to bind to these mammalian cells that would then allow it to transmit from mammal-to-mammal [and potentially human-to-human].'
While jumping between species carries the risk of a freak mutation, experts are particularly concerned about the virus getting into one population: pigs.
Pigs have the same receptors on their lungs — called alpha 2, 6 — as humans and they can harbor both bird and human viruses simultaneously.
Infections in pigs would be a warning sign that the virus has developed a mutation allowing it to bind to this receptor and a sign it could spread to humans.
There is also a risk of a pig being infected with a human and bird flu virus at the same time which could swap genes to make a new and potentially more dangerous virus.
In 2009, a swine flu outbreak occurred when a pig was infected with a human and bird flu virus simultaneously. This allowed the bird virus to use the human virus blueprint to start spreading between humans.
The outbreak led to 60million swine flu infections in humans in the US alone, nearly 300,000 hospitalizations and an estimated 12,400 deaths.
John Fulton, a pharmaceutical industry expert working on a bird flu vaccine, told DailyMail.com: 'I think we are way past “if” and well on our way to when…' when asked if this H5N1 strain would cause an outbreak in humans.
He has been working on developing a vaccine against bird flu for years, because the seasonal vaccines used to protect against human flu does not offer protection.
He is now around 18 months away from creating a new shot for poultry.
Even the experts who aren't too concerned about the case in Texas believe it could be symbolic of the virus beginning to become more dangerous to humans.
Dr Michael Osterholm, who has been tracking bird flu for decades, said: 'These cases are of concern and we will be sure to follow what is happening with them.
'We will have avian influenza pandemics, there is no question.'
Adding caution, he said: 'But we are seeing no cases in swine and swine are the real bridge species for us because they have the same receptor sites in the lungs.'
Dr Bill Schaffner, an infectious diseases expert at Vanderbilt University in Tennessee, said: '[Bird flu cases] happen periodically with humans, but you rarely get human-to-human transmission.
'The genetic part of the virus that would allow it to transmit readily from human-to-human is still missing.'
Heliobas Disciple
TB Fanatic
(fair use applies)
H5N1 Genotype Affecting Cows In America Possibly Gains Entry Into Humans Via The Eyes Thru The New PB2 E67K Mutation
Nikhil Prasad Fact checked by:Thailand Medical News Team
Apr 04, 2024
In a recent revelation by the U.S. Centers for Disease Control and Prevention (CDC), preliminary data regarding the H5N1 avian flu has set off alarms, particularly concerning its potential transmission to humans through an unexpected route - via the eyes. This groundbreaking information is derived from sequencing analysis of H5N1 samples from a patient in Texas who had been exposed to infected cows. The findings not only shed light on the virus's behavior but also unveil critical implications for public health strategies and preparedness measures.
Genomic Analysis: Unraveling Insights into Host Adaptation
The CDC's in-depth genomic sequencing of H5N1 samples has unearthed crucial clues regarding the virus's adaptation and potential transmission pathways. A noteworthy mutation - PB2 E67K - was identified in the human samples, a mutation known for its role in virus adaptation to mammalian hosts.
www.cdc.gov
While this mutation has been observed in previous cases of H5N1 infections, its association with increased transmissibility remains unestablished.
Moreover, comparisons with samples from cattle, wild birds, and poultry revealed minor differences, emphasizing the virus's avian origins. However, the presence of PB2 E67K underscores the dynamic nature of viral evolution and the necessity for vigilant genomic surveillance to track such mutations and their implications for public health.
More Possible cases Unver Investigation.
There have also been speculations that the U.S CDC is investigating other possible cases of human infections involving the new H5N1 genotype in the states of New Mexico and also Kansas but have not released details of those cases to any media covering H5N1 News issues as of yet nor have they issued any official media releases on these cases under investigations.
Clinical Implications: Eye Entry and Respiratory Tract Involvement
The CDC's analysis also delved into the clinical manifestations of H5N1 infection in the Texas patient. Contrary to expectations of respiratory involvement, the patient exhibited symptoms primarily related to the eyes, specifically conjunctivitis. This divergence from typical respiratory symptoms raises concerns about alternative routes of transmission and underscores the importance of comprehensive diagnostic approaches in identifying and managing H5N1 cases.
Despite the lack of respiratory symptoms in the patient, virologists stress the need for heightened awareness and surveillance, as mild cases like conjunctivitis may go unnoticed, potentially providing opportunities for the virus to adapt and escalate in virulence. The emphasis on early detection and isolation remains paramount in mitigating the risk of viral spread and human-to-human transmission.
Protective Eye Goggles Will Possibly Play A Bigger Role In Coming Pandemic
With scientist and researchers already predicting that an imminent H5N1 Avian flu outbreak among humans as the current H5N1 genotypes in circulation among cows, cats and dogs are just one mutation away from evolving into strains that are efficient for human-to-human transmissions. In another scenario, a possible new recombinant variant can emerge with the current H5N1 genotype combining with another zoonotic flu strain such as that like swine flu viruses.
History has shown that most of the lethal flu outbreaks were typically driven by recombinant flu variants including the famous Spanish Flu pandemic.
However, with the current revelation from the preliminary data from the U.S.CDC, it seems that the H5N1 virus is evolving towards more efficient use of receptors found in the human eye for viral entry into the host. Already even for the current COVID-19 crisis, a lot of data is emerging that the SARS-CoV-2 virus is also possibly evolving for better entry via receptors in the human eyes.
Hence, it is very likely that protective goggles will play a very important role in the coming months, not only of for the imminent H5N1 Avian flu outbreak but also for the newer SARS-CoV-2 sub-lineages.
Thailand Medical News also predicts that these new H5N1 genotypes will likely cause more serious brain and neurological issues and also cardiac and gastrointestinal issues than respratory issues!
Vaccine Preparedness and Antiviral Strategies
Amidst these revelations, promising insights emerge regarding vaccine efficacy and antiviral treatments. Analysis of the virus's hemagglutinin (HA) gene suggests a close alignment with candidate vaccine virus (CVV) strains, indicating the potential effectiveness of existing vaccines against the H5N1 genotype. This highlights the importance of proactive vaccine development and distribution strategies in combating emerging viral threats.
Furthermore, assessments of the virus's response to antivirals reveal encouraging findings, with no resistance markers detected in neuraminidase (NA) gene segments. This augurs well for the efficacy of neuraminidase inhibitors like oseltamivir and underscores the importance of diversified antiviral approaches to combat viral infections effectively.
Epidemiological Implications: Herd Confirmations and Surveillance Measures
In parallel developments, the USDA's Animal and Plant Health Inspection Service (APHIS) confirmed cases of highly pathogenic avian influenza in cow herds from Idaho and Ohio. These confirmations, coupled with pending results from other states, underscore the urgent need for comprehensive surveillance and containment measures.
The spread of H5N1 infections among dairy cow farms in the United States is occurring at a rather rapid rate. More dairy farms in the five states in America (New Mexico, Texas, Idaho, Kansas and Michigan) that are currently affected by the H5N1 virus are reporting the discovery of the virus. Suspected cases in dairy farms in Wyoming, Nebraska, Nevada and Utah are also being currently investigated.
The interconnectedness of livestock movements and disease spread highlights the complexity of mitigating viral outbreaks across species boundaries. Enhanced collaboration between health agencies, agricultural departments, and veterinary services is essential in implementing robust surveillance systems and rapid response protocols to curtail the transmission of infectious agents.
Conclusion: Navigating the Landscape of Emerging Infectious Diseases
The revelation of H5N1's potential transmission through ocular routes and its adaptive mutations underscores the evolving landscape of infectious diseases. As scientific advancements provide deeper insights into viral behavior and host interactions, the imperative for proactive surveillance, strategic preparedness, and collaborative interventions becomes increasingly apparent.
Addressing the multifaceted challenges posed by emerging infectious diseases demands a holistic approach encompassing genomic surveillance, clinical vigilance, vaccine development, and robust public health infrastructures. By fostering interdisciplinary collaborations and leveraging technological innovations, we can navigate the complexities of viral threats and safeguard global health resilience in the face of evolving pandemics.
H5N1 Genotype Affecting Cows In America Possibly Gains Entry Into Humans Via The Eyes Thru The New PB2 E67K Mutation
Nikhil Prasad Fact checked by:Thailand Medical News Team
Apr 04, 2024
In a recent revelation by the U.S. Centers for Disease Control and Prevention (CDC), preliminary data regarding the H5N1 avian flu has set off alarms, particularly concerning its potential transmission to humans through an unexpected route - via the eyes. This groundbreaking information is derived from sequencing analysis of H5N1 samples from a patient in Texas who had been exposed to infected cows. The findings not only shed light on the virus's behavior but also unveil critical implications for public health strategies and preparedness measures.
Genomic Analysis: Unraveling Insights into Host Adaptation
The CDC's in-depth genomic sequencing of H5N1 samples has unearthed crucial clues regarding the virus's adaptation and potential transmission pathways. A noteworthy mutation - PB2 E67K - was identified in the human samples, a mutation known for its role in virus adaptation to mammalian hosts.
Summary Analysis of Genetic Sequences of HPAI A(H5N1) Viruses in Texas
Summary Analysis of Genetic Sequences of HPAI A(H5N1) Viruses in Texas
www.cdc.gov
While this mutation has been observed in previous cases of H5N1 infections, its association with increased transmissibility remains unestablished.
Moreover, comparisons with samples from cattle, wild birds, and poultry revealed minor differences, emphasizing the virus's avian origins. However, the presence of PB2 E67K underscores the dynamic nature of viral evolution and the necessity for vigilant genomic surveillance to track such mutations and their implications for public health.
More Possible cases Unver Investigation.
There have also been speculations that the U.S CDC is investigating other possible cases of human infections involving the new H5N1 genotype in the states of New Mexico and also Kansas but have not released details of those cases to any media covering H5N1 News issues as of yet nor have they issued any official media releases on these cases under investigations.
Clinical Implications: Eye Entry and Respiratory Tract Involvement
The CDC's analysis also delved into the clinical manifestations of H5N1 infection in the Texas patient. Contrary to expectations of respiratory involvement, the patient exhibited symptoms primarily related to the eyes, specifically conjunctivitis. This divergence from typical respiratory symptoms raises concerns about alternative routes of transmission and underscores the importance of comprehensive diagnostic approaches in identifying and managing H5N1 cases.
Despite the lack of respiratory symptoms in the patient, virologists stress the need for heightened awareness and surveillance, as mild cases like conjunctivitis may go unnoticed, potentially providing opportunities for the virus to adapt and escalate in virulence. The emphasis on early detection and isolation remains paramount in mitigating the risk of viral spread and human-to-human transmission.
Protective Eye Goggles Will Possibly Play A Bigger Role In Coming Pandemic
With scientist and researchers already predicting that an imminent H5N1 Avian flu outbreak among humans as the current H5N1 genotypes in circulation among cows, cats and dogs are just one mutation away from evolving into strains that are efficient for human-to-human transmissions. In another scenario, a possible new recombinant variant can emerge with the current H5N1 genotype combining with another zoonotic flu strain such as that like swine flu viruses.
History has shown that most of the lethal flu outbreaks were typically driven by recombinant flu variants including the famous Spanish Flu pandemic.
However, with the current revelation from the preliminary data from the U.S.CDC, it seems that the H5N1 virus is evolving towards more efficient use of receptors found in the human eye for viral entry into the host. Already even for the current COVID-19 crisis, a lot of data is emerging that the SARS-CoV-2 virus is also possibly evolving for better entry via receptors in the human eyes.
Hence, it is very likely that protective goggles will play a very important role in the coming months, not only of for the imminent H5N1 Avian flu outbreak but also for the newer SARS-CoV-2 sub-lineages.
Thailand Medical News also predicts that these new H5N1 genotypes will likely cause more serious brain and neurological issues and also cardiac and gastrointestinal issues than respratory issues!
Vaccine Preparedness and Antiviral Strategies
Amidst these revelations, promising insights emerge regarding vaccine efficacy and antiviral treatments. Analysis of the virus's hemagglutinin (HA) gene suggests a close alignment with candidate vaccine virus (CVV) strains, indicating the potential effectiveness of existing vaccines against the H5N1 genotype. This highlights the importance of proactive vaccine development and distribution strategies in combating emerging viral threats.
Furthermore, assessments of the virus's response to antivirals reveal encouraging findings, with no resistance markers detected in neuraminidase (NA) gene segments. This augurs well for the efficacy of neuraminidase inhibitors like oseltamivir and underscores the importance of diversified antiviral approaches to combat viral infections effectively.
Epidemiological Implications: Herd Confirmations and Surveillance Measures
In parallel developments, the USDA's Animal and Plant Health Inspection Service (APHIS) confirmed cases of highly pathogenic avian influenza in cow herds from Idaho and Ohio. These confirmations, coupled with pending results from other states, underscore the urgent need for comprehensive surveillance and containment measures.
The spread of H5N1 infections among dairy cow farms in the United States is occurring at a rather rapid rate. More dairy farms in the five states in America (New Mexico, Texas, Idaho, Kansas and Michigan) that are currently affected by the H5N1 virus are reporting the discovery of the virus. Suspected cases in dairy farms in Wyoming, Nebraska, Nevada and Utah are also being currently investigated.
The interconnectedness of livestock movements and disease spread highlights the complexity of mitigating viral outbreaks across species boundaries. Enhanced collaboration between health agencies, agricultural departments, and veterinary services is essential in implementing robust surveillance systems and rapid response protocols to curtail the transmission of infectious agents.
Conclusion: Navigating the Landscape of Emerging Infectious Diseases
The revelation of H5N1's potential transmission through ocular routes and its adaptive mutations underscores the evolving landscape of infectious diseases. As scientific advancements provide deeper insights into viral behavior and host interactions, the imperative for proactive surveillance, strategic preparedness, and collaborative interventions becomes increasingly apparent.
Addressing the multifaceted challenges posed by emerging infectious diseases demands a holistic approach encompassing genomic surveillance, clinical vigilance, vaccine development, and robust public health infrastructures. By fostering interdisciplinary collaborations and leveraging technological innovations, we can navigate the complexities of viral threats and safeguard global health resilience in the face of evolving pandemics.
desertvet2
Veteran Member
I did tell you that covid was a dry run for what was REALLY coming.
Guess who they come for FIRST this time...
The resistors.
Guess who they come for FIRST this time...
The resistors.
Profit of Doom
Dismember
Panic early, beat the rush.
Profit of Doom
Dismember
I noticed at least two of the above posts were working climate change into their narrative. I’m calling bullshit. Far bigger fish to fry. Also, don’t think vaccines are going to be much use.
Heliobas Disciple
TB Fanatic
tweet not found (removed). Do you remember what it said?
Heliobas Disciple
TB Fanatic
Rintrah is heavy into climate change and vegetarianism. Don't throw the baby out with the bathwater. His analysis on viruses and the immune system is spot on. Ignore the parts you don't agree with.
HD
Heliobas Disciple
TB Fanatic
While I was absent from the board I did save links to post when I got back. It just took longer than I expected and now it's too overwhelming to post all those articles. With permission from ADMIN, I am as a one time 'catch-up' thing, going to post the links to the articles I missed out on posting so that the thread has the news from the last 3 weeks archived on this thread. If any article interests you, please do click on the link!
www.igor-chudov.com
childrenshealthdefense.org
apnews.com
www.theepochtimes.com
www.theepochtimes.com
www.theepochtimes.com
www.theepochtimes.com
www.theepochtimes.com
www.zerohedge.com
medicalxpress.com
www.theepochtimes.com
medicalxpress.com
medicalxpress.com
voiceforscienceandsolidarity.substack.com
www.voiceforscienceandsolidarity.org
voiceforscienceandsolidarity.substack.com
www.igor-chudov.com
news.yahoo.com
voiceforscienceandsolidarity.substack.com
www.thegatewaypundit.com
news.yahoo.com
managainstthemicrobes.substack.com
childrenshealthdefense.org
www.theepochtimes.com
www.theepochtimes.com
Excess Mortality Still Correlated With COVID Vaccination Rate - Dec 2023 data
Data to be swept under the rug, as usual
www.igor-chudov.com
‘Blood on Its Hands’: FDA Will Remove Anti-ivermectin Social Media, Website Posts Under Lawsuit Settlement Agreement
The FDA, which denied any wrongdoing, said it will remove content warning people not to use ivermectin to treat COVID-19 within 21 days. Plaintiffs called the settlement a big win for patients and the patient-physician relationship.
childrenshealthdefense.org
Louisiana debates civil liability over COVID-19 vaccine mandates, or the lack thereof
Three years after COVID-19 vaccines became widely available in the United States, Louisiana continues to debate policies related to inoculation mandates, including civil labilities if a work place mandates vaccines or not.
apnews.com
Pfizer Finally Releases Myocarditis Study for Children Who Received COVID-19 Vaccine
Some children experienced chest pain and other symptoms.
www.theepochtimes.com
Researchers Warn Against Blood Bank Contamination From mRNA Vaccinated Individuals
Since there are no reliable ways to separate spike proteins and mRNA from vaccinated blood, authors recommended discarding their usage.
www.theepochtimes.com
Researchers Concerned About Blood Transfusions From Vaccinated and Long-COVID Patients, Propose Changes: Preprint
The authors propose a system to track the health outcomes of blood recipients and that blood donors’ prior vaccine and infection history be recorded.
www.theepochtimes.com
DNA May Be Altered by COVID Infection or Vaccine, Potentially Leading to Cancer
DNA within the core of our cells is vulnerable to harmful insults. Many people are unaware that our DNA may be altered by a COVID-19 infection or vaccination.
www.theepochtimes.com
Rare Neurological Disorder Linked to COVID-19 Vaccination, Research Suggests
A recently published review in Vaccines shows COVID-19 vaccines may trigger Parsonage–Turner syndrome—a condition that causes intense pain and muscle atrophy.
www.theepochtimes.com
CCP-Linked Virologist Fired After Transferring Ebola From Winnipeg To Wuhan Resurfaces In China - And Is Collaborating With Military Scientists | ZeroHedge
ZeroHedge - On a long enough timeline, the survival rate for everyone drops to zero
www.zerohedge.com
Unveiling the Molecular Conspiracy: COVID-19’s Exploitation of Fragile X
Researchers have found an unexpected connection between coronavirus and Fragile X Syndrome, which is the most common hereditary cause of intellectual disability. How does coronavirus spread through the body? A new study can help us answer that question. Professor Jakob Nilsson from the Novo Nordi
scitechdaily.com
COVID-19 Vaccination’s Timing Linked to Menstrual Cycle Changes
However, the findings present no cause for alarm and are an important step in understanding the vaccine's overall impact on health. Researchers at Oregon Health & Science University have confirmed a link between the timing of COVID-19 vaccination and slight, temporary changes in the length of m
scitechdaily.com
Breaking: Emerging Evidence Suggests COVID-19 Originated in a Lab
Research points to an unnatural origin as the likely source for COVID-19. The origin of COVID-19 is highly debated – most studies have focused on a zoonotic origin, but research from the journal Risk Analysis, examined the likelihood of an unnatural origin (i.e. from a laboratory.) The results i
scitechdaily.com
Study explores characteristics associated with poor COVID-19 antibody response
Adults with certain socio-demographic and clinical characteristics may have weaker antibody responses to COVID-19 vaccination, which could leader to a higher risk of infection, according to a recent study published in Nature Communications.
Vaccinated People Are Immune Imprinted, Have Unusual Response to COVID-19 mRNA Boosters
Immune imprinting occurs when previous exposures leave such a strong immune memory that the body continues to produce antibodies targeting the past experience.
www.theepochtimes.com
COVID-19 Had a Much Greater Impact on Life Expectancy Than Previously Thought
A recent study published in The Lancet never-before-seen unprecedented details on the exceptionally high death rates due to the COVID-19 pandemic both within nations and internationally. Regions including Mexico City, Peru, and Bolivia experienced some of the most significant reductions in life expe
scitechdaily.com
Mathematicians Use AI and New Clustering Algorithm To Identify Emerging COVID-19 Variants
An AI framework aids in identifying and tracking new COVID-19 variants, using a novel algorithm named CLASSIX to efficiently process large genomic datasets and enhance early detection efforts. Scientists at The Universities of Manchester and Oxford have developed an AI framework that can identify
scitechdaily.com
Google's HeAR AI system uses sounds to detect lung diseases, such as COVID-19
A team of AI researchers at Google Research, working with a pair of colleagues from the Center of Infectious Disease Research in Zambia, has developed a machine learning system aimed at diagnosing lung diseases based on the sounds of coughing. In their study, available as a preprint on the arXiv...
COVID-19 research: Study reveals new details about potentially deadly inflammation
A recent USC study provides new information about why SARS-CoV-2, the virus behind the COVID-19 pandemic, may elicit mild symptoms at first but then, for a subset of patients, turn potentially fatal a week or so after infection. The researchers showed that distinct stages of illness correspond...
Nature will unambiguously demonstrate that neither the unvaccinated nor the vaccinated who refused to re-vaccinate can be blamed for the imminent transition of this immune escape pandemic to its final
The emergence of cryptic lineages: Another example of how a lack of immunological insight leads to empty prejudices. People often speculate that if my predictions come true (of which I remain 100% convinced), the unvaccinated will once again be scapegoated for exacerbating the public health...
voiceforscienceandsolidarity.substack.com
The Iron Twist: The Unexpected Driver of Long COVID
Iron levels and inflammation after COVID-19 infection are linked to long COVID, with research indicating that early intervention in iron regulation could mitigate long-term symptoms. Problems with iron levels in the blood and the body’s ability to regulate this important nutrient as a result of S
scitechdaily.com
I can now spot the tsunami at the horizon | Voice for Science and Solidarity
There shall be no doubt that the responsibility of this unprecedented gain-of-function experiment on the very human species solely lies with
www.voiceforscienceandsolidarity.org
Come on, give me a break!
I am peeing in my pants from laughing! Read this! https://www.nytimes.com/2024/03/22/health/coronavirus-evolution-immunity.html?smid=url-share (subscribe for free or read the article on my website as of Tue April 2nd) Due to an astonishing lack of immunological understanding of the host’s immune...
voiceforscienceandsolidarity.substack.com
Monkeypox Boosters Discussed as Vaccine Antibodies Drop to Zero In Just a Year
A very "unexpected" development!
www.igor-chudov.com
People in red states report more COVID vaccine side effects: Study
A new study found that states with a higher percentage of Republican voters are seeing more reports of adverse side effects from COVID-19 vaccines. The study published in the JAMA medical journal looked at 620,456 vaccine adverse events reported to the federal Vaccine Adverse Event Reporting...
Scientists continue to disregard Darwin's theories and incorrectly and vaguely attribute ‘immune suppression’(!) as the cause of the chronic shedding of evolving SARS-CoV-2 immune escape variants duri
Scientists continue to disregard Darwin's theory and incorrectly and vaguely attribute ‘immune suppression’(!) as the cause of the chronic shedding of evolving SARS-CoV-2 immune escape variants during this 'chronic phase' of the pandemic. During the ‘acute’ phase of the Covid-19 (C-19)
voiceforscienceandsolidarity.substack.com
Top International Virologist Issues Dire Warning: "Massive, Massive Tsunami of Death Among Highly Vaccinated...is Imminent" | The Gateway Pundit | by Cullen Linebarger
A world-leading virologist has issued a shocking warning to the American public that a “massive tsunami” of death will soon destroy the global COVID-19 vaccinated population.
www.thegatewaypundit.com
The Invisible Assault: How COVID-19 Clandestinely Ravages the Heart
NIH-supported research shows that the virus that causes COVID-19 can damage the heart without directly infecting heart tissue. SARS-CoV-2, the virus that causes COVID-19, can damage the heart even without directly infecting the heart tissue, a National Institutes of Health-supported study has fou
scitechdaily.com
COVID subcommittee chair asks top science journal editors to testify on relationship with federal government
Rep. Brad Wenstrup (R-Ohio), chair of the House Select Subcommittee on the Coronavirus Pandemic, issued letters to the editors of three major science journals on Tuesday, asking them to testify on the relationship between their publications and the federal government. Wenstrup sent letters to...
Blood reaches new catastrophic levels of alteration. DOD Erythromer like tech in full swing. Coacervates, Proteinosomes, and more.
No one can hide this now. All one has to do is look on a good lab grade industrial scope.
managainstthemicrobes.substack.com
Groundbreaking Study Reveals Potential Treatment for COVID-19 Brain Fog
Memory loss and learning difficulties are among the many confounding symptoms observed in individuals recovering from COVID-19. Yet little is known about the mechanisms of cognitive impairments like these, commonly called brain fog. In a new study, researchers at the University of Illinois Chicag
scitechdaily.com
27% of Saudis in 'Bombshell' Study Experienced Heart Issues After mRNA COVID Shots
A study from Saudi Arabia reported on by TrialSite News found that 27.11% of participants experienced heart complications following mRNA COVID-19 vaccination, with onset ranging from within one month to more than a year later.
childrenshealthdefense.org
Paxlovid Doesn’t Work in Many Vaccinated People: Pfizer Study
The new paper describes the results of a COVID-19 drug clinical trial.
www.theepochtimes.com
Study Suggests Link Between Rising Cancer Death Rates and COVID-19 Vaccination
COVID-19 vaccines were rolled out in 2021, prioritized for vulnerable groups like those with cancer, the researchers pointed out.
www.theepochtimes.com
Heliobas Disciple
TB Fanatic
More on the bird flu.
EVEN IF this is a deliberate GOF release, that doesn't mean it can't hurt you. Actually it's more likely to hurt you than something that showed up in the wild. So please pay attention whether or not you think this is a natural occurrence or just 'fear mongering' by TPTB. The TPTB have proven to us over the last 4 years that their fear mongering is reality based and not woo based.
~~~~~~~~~~~~
www.thegatewaypundit.com
(fair use applies)
Here We Go: Scientists Warn Bird Flu Pandemic Could Be ‘100 Times Worse’ Than COVID-19
by Jim Hoft
Apr. 4, 2024 3:20 pm
Amidst growing concerns, experts have cautioned that a bird flu pandemic may be looming on the horizon, one that could be catastrophic on a scale ‘100 times worse than Covid-19.’
The alarm was raised following reports of the virus being found in multiple species, including cows, cats, and humans, which could potentially accelerate the virus’s mutation to become more transmissible among humans.
In March 2024, testing for influenza was conducted on several animals in Texas and Kansas due to signs of illness. These animals included wild birds, cats, and dairy cows. Some of these tests returned positive for avian influenza A(H5N1), marking the first time the virus has been detected in cattle within the United States.
The Gateway Pundit previously reported that a Highly Pathogenic Avian Influenza (HPAI), initially detected in dairy cows in Texas and Kansas, has now spread to additional herds in Michigan, Idaho, and New Mexico.
On Monday, the Texas Department of State Health Services (DSHS) issued a health alert after confirming the first human case of the novel avian influenza A(H5N1) in the state.
“The patient became ill following contact with dairy cows presumed to be infected with avian influenza. The patient’s primary symptom was conjunctivitis. This is the second case of avian influenza A(H5N1) identified in a person in the United States and is believed to be associated with the recent detections of avian influenza A(H5N1) in dairy cows announced by the Texas Animal Health Commission,” according to DSHS.
During a recent briefing, scientists highlighted the increasing risk of the H5N1 bird flu strain turning into a pandemic.
The meeting, attended by leading bird flu researchers, medical professionals, and government officials, was convened in response to the human bird flu case and organized by John Fulton, a vaccine consultant and pharmaceutical industry expert, according to Daily Mail.
“This appears to be 100 times worse than Covid, or it could be if it mutates and maintains its high case fatality rate,” said Fulton. “Once it’s mutated to infect humans, we can only hope that the [fatality rate] drops.”
Dr. Suresh Kuchipudi, a notable figure in bird flu research, warned of the virus’s potential for a pandemic, highlighting its global distribution and ability to infect a variety of mammals, including humans.
“And now we are getting dangerously close to this virus potentially causing a pandemic,” Kuchipudi said.
“H5N1 viruses have already demonstrated several important features of a potential pandemic virus. So these are, the virus is already globally distributed, and this virus particularly, that is often perceived as an avian virus, it can, and it has shown, the ability to infect a range of mammalian hosts including humans.
“We are not really talking about a virus that is yet to make a jump, we are talking about a virus that is globally present, already infecting a range of mammals and is circulating. So, therefore, in my view, I think this is a virus that has the greatest pandemic threat [that is] playing out in plain sight and is globally present. It is really high time that we are prepared,” he added.
According to the World Health Organization, the H5N1 fatality rate stands at an alarming 52 percent, a stark contrast to the less than 0.1 percent mortality rate of Covid-19. The concern is that if H5N1 becomes easily transmitted among humans while maintaining its high fatality rate, the consequences could be dire.
EVEN IF this is a deliberate GOF release, that doesn't mean it can't hurt you. Actually it's more likely to hurt you than something that showed up in the wild. So please pay attention whether or not you think this is a natural occurrence or just 'fear mongering' by TPTB. The TPTB have proven to us over the last 4 years that their fear mongering is reality based and not woo based.
~~~~~~~~~~~~
Here We Go: Scientists Warn Bird Flu Pandemic Could Be '100 Times Worse' Than COVID-19 | The Gateway Pundit | by Jim Hᴏft
Amidst growing concerns, experts have cautioned that a bird flu pandemic may be looming on the horizon, one that could be catastrophic on a scale ‘100 times worse than Covid-19.’ The alarm was raised following reports of the virus being found in multiple species, including cows, cats, and...
www.thegatewaypundit.com
Here We Go: Scientists Warn Bird Flu Pandemic Could Be ‘100 Times Worse’ Than COVID-19
by Jim Hoft
Apr. 4, 2024 3:20 pm
Amidst growing concerns, experts have cautioned that a bird flu pandemic may be looming on the horizon, one that could be catastrophic on a scale ‘100 times worse than Covid-19.’
The alarm was raised following reports of the virus being found in multiple species, including cows, cats, and humans, which could potentially accelerate the virus’s mutation to become more transmissible among humans.
In March 2024, testing for influenza was conducted on several animals in Texas and Kansas due to signs of illness. These animals included wild birds, cats, and dairy cows. Some of these tests returned positive for avian influenza A(H5N1), marking the first time the virus has been detected in cattle within the United States.
The Gateway Pundit previously reported that a Highly Pathogenic Avian Influenza (HPAI), initially detected in dairy cows in Texas and Kansas, has now spread to additional herds in Michigan, Idaho, and New Mexico.
On Monday, the Texas Department of State Health Services (DSHS) issued a health alert after confirming the first human case of the novel avian influenza A(H5N1) in the state.
“The patient became ill following contact with dairy cows presumed to be infected with avian influenza. The patient’s primary symptom was conjunctivitis. This is the second case of avian influenza A(H5N1) identified in a person in the United States and is believed to be associated with the recent detections of avian influenza A(H5N1) in dairy cows announced by the Texas Animal Health Commission,” according to DSHS.
During a recent briefing, scientists highlighted the increasing risk of the H5N1 bird flu strain turning into a pandemic.
The meeting, attended by leading bird flu researchers, medical professionals, and government officials, was convened in response to the human bird flu case and organized by John Fulton, a vaccine consultant and pharmaceutical industry expert, according to Daily Mail.
“This appears to be 100 times worse than Covid, or it could be if it mutates and maintains its high case fatality rate,” said Fulton. “Once it’s mutated to infect humans, we can only hope that the [fatality rate] drops.”
Dr. Suresh Kuchipudi, a notable figure in bird flu research, warned of the virus’s potential for a pandemic, highlighting its global distribution and ability to infect a variety of mammals, including humans.
“And now we are getting dangerously close to this virus potentially causing a pandemic,” Kuchipudi said.
“H5N1 viruses have already demonstrated several important features of a potential pandemic virus. So these are, the virus is already globally distributed, and this virus particularly, that is often perceived as an avian virus, it can, and it has shown, the ability to infect a range of mammalian hosts including humans.
“We are not really talking about a virus that is yet to make a jump, we are talking about a virus that is globally present, already infecting a range of mammals and is circulating. So, therefore, in my view, I think this is a virus that has the greatest pandemic threat [that is] playing out in plain sight and is globally present. It is really high time that we are prepared,” he added.
According to the World Health Organization, the H5N1 fatality rate stands at an alarming 52 percent, a stark contrast to the less than 0.1 percent mortality rate of Covid-19. The concern is that if H5N1 becomes easily transmitted among humans while maintaining its high fatality rate, the consequences could be dire.