paul bunyan
Frostbite Falls, Minnesota
Original Article is from the Journal "Nature" and is available as an abstract for free
Wonderful Nose, Nares, Info To Follow:
http://www.nature.com/nature/journal/v535/n7613/full/nature18634.html
Nature Article Human commensals (native friendly bugs ) producing a novel antibiotic impair pathogen colonization (in the nose/ nares)
Nature 535,511–516(28 July 2016)doi:10.1038/nature18634 Received 12 November 2015 Accepted 09 June 2016 Published online 27 July 2016 Article tools
Abstract
We show that nasal Staphylococcus lugdunensis strains produce lugdunin, a novel thiazolidine-containing cyclic peptide antibiotic that prohibits colonization by Staph. aureus , and a rare example of a non-ribosomally synthesized bioactive compound from human-associated bacteria.
Lugdunin is bactericidal against major pathogens, effective in animal models, and not prone to causing development of resistance in S. aureus. Notably, human nasal colonization by S. lugdunensis was associated with a significantly reduced S. aureus carriage rate, suggesting that lugdunin or lugdunin-producing commensal bacteria could be valuable for preventing staphylococcal infections. Moreover, human microbiota should be considered as a source for new antibiotics.
Full article available by payment,,,heh
YMMV,
Nose pickers, Carry on!
PB
Wonderful Nose, Nares, Info To Follow:
http://www.nature.com/nature/journal/v535/n7613/full/nature18634.html
Nature Article Human commensals (native friendly bugs ) producing a novel antibiotic impair pathogen colonization (in the nose/ nares)
Nature 535,511–516(28 July 2016)doi:10.1038/nature18634 Received 12 November 2015 Accepted 09 June 2016 Published online 27 July 2016 Article tools
Abstract
- Abstract•
- References•
- Author information•
- Extended data figures and tables•
- Supplementary information
We show that nasal Staphylococcus lugdunensis strains produce lugdunin, a novel thiazolidine-containing cyclic peptide antibiotic that prohibits colonization by Staph. aureus , and a rare example of a non-ribosomally synthesized bioactive compound from human-associated bacteria.
Lugdunin is bactericidal against major pathogens, effective in animal models, and not prone to causing development of resistance in S. aureus. Notably, human nasal colonization by S. lugdunensis was associated with a significantly reduced S. aureus carriage rate, suggesting that lugdunin or lugdunin-producing commensal bacteria could be valuable for preventing staphylococcal infections. Moreover, human microbiota should be considered as a source for new antibiotics.
Full article available by payment,,,heh
YMMV,
Nose pickers, Carry on!
PB