CORONA Main Coronavirus thread

Heliobas Disciple

TB Fanatic
CONTINUED:

Thank you. And as a reminder, if you would like to ask a question, please press star one. Limit to one question and one follow-up. Our next question comes from Eben from Fox news. Your line is now open.

Q: Thank you very much for doing the call today. There has been some political back and forth now that democrats are accusing the president which essentially means the administration and everything that falls under that as being ill prepared for coronavirus, requesting too little of amount in terms of their request for $2.5 billion. Do you feel that we are ill prepared from a financial standpoint? I know you are a clinician and I don’t want you to get too much into politics, but do you have what you need to do your job?

A: I guess I’ll answer that two ways. The first is HHS can provide information or answer questions about the funds that are available. What I can say from my perspective is I’ve been at CDC for 25 years and that if you asked public health officials over the course of that time what they feared as an expectation, it was something exactly like this. And so the idea that we might have a pandemic of influenza or a pandemic of a respiratory viral infection is something that we’ve known about and have been planning and preparing for. That’s why we at CDC have been exercising with the state and local health departments. That’s why the whole of government exercise last year, that’s why we’ve invested so much on the foundation we are now responding.

But that being said, we are never going to ever be able to be so completely prepared that we’re prepared for any inevitability. We always are going to find that diseases surprise us and that there was some consideration that is slightly different from what we planned for. So have we made a lot of progress in the 25 years I’ve been here? Yes. Are we better prepared today than we were 20 years ago? Yes. But are we completely prepared? You know, diseases surprise us and therefore we need to be reacting to the current situation even if it differs from what we planned for.

You know, in general we are asking the American public to work with us to prepare in the expectation that this could be bad. I continue to hope that in the end we’ll look back and feel like we are over-prepared, but that is a better place to be in than being under-prepared. And just like the preparedness for a pandemic influenza provides such a strong foundation for this response, any preparedness we do as a country, at schools, businesses, within our families will always be helpful for whatever the next event is. And so I don’t think in general that preparedness will ever go to waste. Next question, please.

Thank you. Our next question comes from Mike from A.P. Your line is now open.

Q: Hi. Thank you for taking my call. If I could ask a couple. One is just the latest case count, it’s been a little confusing for some of us just to sort out exactly how many U.S. cases there are and how they’re being sorted out. Second, if you could speak to your best and latest understanding of the severity of the disease. Of course there’s some news today about the WHO mission coming back and statements about not finding a lot of undetected cases. I was wondering if that’s related to CDC gearing up for these NPIs. And lastly, talking about the exercising you’ve been doing, what was the weakness or weaknesses that kept coming up in the exercises that you’re most concerned about and you’re really trying to stay on top of now that we have a real time experience happening? Thank you.

A: Okay. So let me — so let me start by saying that I know the case counts can be confusing. I will try to sort out what the numbers are as of today and try to explain why it perhaps is a little confusing. There remain 14 confirmed U.S. cases. We are separating out the cases among repatriated individuals. So those are 14 U.S. Cases. 12 of those are travelers who returned from an area where disease is circulating. Two of those are close contacts of another case. That’s 14. There are three novel coronavirus patients among people who are repatriated from Hubei that is in the repatriated flights. And our website says 36 because we updated this yesterday, but in fact as of this morning, there are 40 positives among individuals repatriated from the “Diamond Princess.” so these are Americans who were on board the “Diamond Princess” repatriated back to the United States. And that’s 40. So that means just to go back that there are 14 confirmed cases picked up through the U.S. public health systems. And 40 plus 3 makes 43 among individuals repatriated into the United States. I do hope that helps.

In terms of the severity, I think that there are a variety of reports that give information about severity. We’ve looked at severity among people, among reported people from Hubei. We’ve looked at reported people from elsewhere in china. And certainly the data coming out from Korea and Iran and Italy suggests also deaths which are concerning.

In terms of our messaging today, I really would say that it is more driven by the community spread in other countries than it is specifically from data from china. And so I think it really is the spreading of COVID-19 through other countries that makes all of us feel that the risk of spread in the united states has — is increasing.

In terms of exercising, you know, there are always small and big things that we learn from exercising. Maybe two specific things I’ll point out is that our exercising did show us that if we had a pandemic, there were going to be supply issues. And I think that we are now across the whole of government thinking through and working on those supply issues. One of them is enough protection for health care workers. This is clearly a priority. The health care workers put themselves on the front line caring for ill patients and has to be a priority to make sure they are protected.

Another issue is the NPIs. The non-pharmaceutical interventions. We have worked across governmental sectors to get input into our planning guidance. But it’s one thing to plan for those NPIs. It’s certainly another thing to be able to implement them at a large scale. And I think one of the reasons that we’re talking about this so proactively today is that we recognize that implementing NPIs at this level that we want to prepare the american people that their lives could be interrupted. Next.

Thank you. Our next question comes from Eric of ABC news. Your line is open.

Q: Thanks, Benjamin. Thanks, Nancy for taking our questions. I’m wondering like the chicken and the egg with the case definition and the testing. If you’re telling us today it’s not a question of if but when there’ll be community spread and it’s very difficult to — for clinicians to know the difference between flu and COVID-19, how come you’re not widening the case definition to test more people?

A: So let me answer that two ways. One is that we have more than one layer of surveillance. I think I talked about this in a previous call, but maybe just to talk about it a little more. There is a specific patient-under-investigation case definition that really does focus on travel because that is where the cases that are picked up through our public health systems are.

But we are also aware and concerned about the possibility for broader spread in the U.S. That’s why the Secretary and we announced last week that we were going to be doing more community-based surveillance relying on the infrastructure of our influenza. So we have already started that surveillance system. We’re rapidly working within the next couple weeks to expand that more broadly. As well, we have a variety of other more community-oriented surveillance systems that we’re working to stand up to be able to look for those cases in the community. So this is proceeding in stages with the one surveillance but community surveillance also rapidly starting. Brittany, we have time for two more questions, please.

Thank you. And our next question comes from Lauren from San Antonio Express News. Your line is now open.

Q: Thank you for taking my call. I wanted to ask about the 14-day incubation period that has been reiterated by many public health officials including the quarantine of the evacuees. We’ve seen some isolated reports coming from other countries suggesting that it is possible that the incubation period has been longer in some individuals in other countries who have been quarantined for more than 14 days. And I was wondering if you guys have any reason to suspect whether the incubation period may be longer than 14 days for those of Wuhan that have been released from their quarantine.

A: Thank you. That’s actually a really important question. And something we’re looking at closely. Some of the reports that you’ve seen are reports in the media, not reports in peer reviewed literature. And it impacts our ability to fully scientifically evaluate them. As I’ve said in previous meetings, there are a team of — there are more than 50 modeling mathematical modeling groups in the United States all working with us to look at a variety of issues around this response to novel coronavirus. One of the things they’re certainly analyzing is all of the available data on the incubation period. And the data so far still supports using 14 days as the top window.

In terms of isolated reports elsewhere, there are a variety of possibilities. One possibility is — there’s a variety of possibilities – what we’ll do is continue to synthesize and evaluate the available data trying to make a data-driven decision. And if more data becomes available that suggests a longer incubation period, we will certainly be visible and public about that. I think at this point, we’re still comfortable that 14 days is the appropriate top line for that. Last question, please.

Thank you. And our final question comes from Ben from CNN. Your line is now open.

Q: Hi, thanks so much for taking my question. This morning while he was traveling in India, President Trump said that he thinks that the coronavirus is a problem that is going to go away. He seems very optimistic about this and we’re trying to figure out exactly why he believes so strongly that to be the case. And so my question for you is what information is your agency specifically giving the president and the White House about the current state of the coronavirus outbreak?

A: As you imagine, we brief the Secretary daily and the Secretary is the lead of the White House task force. And Dr. Redfield the CDC director is briefing them daily. In terms of the course of this illness, we have a — again, a team of mathematical modelers working with us to try to predict the trajectory. One hypothesis is that we could be hopeful that this could potentially be seasonal. Other viral respiratory diseases are seasonal including influenza and therefore in many viral respiratory diseases, we do see a decrease in disease in spring and summer. And so we could certainly be optimistic that this disease will follow suit. But we’re not going to know that until time keeps ticking forward. We’re going to be, again, preparing as if this is going to continue, preparing as if we’re going to see community spread in the near term. But I’m always going to be hopeful that that disease will decline either for the summer or that, you know, we’ll be over-prepared and we won’t see the high levels of transmission here in the U.S.

Thank you, doctor. And thank you, all, for joining us for today’s briefing. Please visit CDC’s 2019 novel coronavirus website for continued updates. And if you have further questions, please call the main media line at 404-639-3286 or email media@CDC.gov. Thank you. Thank you for your participation in today’s conference. All participants may disconnect at this time.
 

Heliobas Disciple

TB Fanatic
This is the only transcript I could find of Pres Trump's press conference. This is how it was posted, I did not format it. Unfortunately I couldn't find the Q&A part, which is the part I really wanted to post. But at least we have the scripted part for now.

(fair use applies)

Feb 26, 2020
Donald Trump Coronavirus Press Conference Transcript: Trump and CDC Give Coronavirus Updates


Donald Trump: (00:02)
Thank you very much, everybody. Thank you very much.

Speaker 2: (00:04)
Thank you.

Donald Trump: (00:05)
Before I begin, I’d like to extend my deepest condolences to the victims and families in Milwaukee, Wisconsin. Earlier today, a wicked murderer opened fire at a Molson Coors Brewing Company plant, taking the lives of five people. A number of people were wounded, some badly wounded. Our hearts break for them and their loved ones. We send our condolences. We’ll be with them. And it’s a terrible thing, terrible thing. So our hearts go out to the people of Wisconsin and to the families. Thank you very much.

Donald Trump: (00:49)
I have just received another briefing from a great group of talented people on the virus that is going around to various parts of the world. We have through some very good early decisions, decisions that were actually ridiculed at the beginning. We closed up our borders to flights coming in from certain areas, areas that were hit by the coronavirus and hit pretty hard. And we did it very early. A lot of people thought we shouldn’t have done it that early, and we did, and it turned out to be a very good thing. The number one priority from our standpoint, is the health and safety of the American people. That’s the way I viewed it when I made that decision. Because of all we’ve done, the risk to the American people remains very low. We have the greatest experts really, in the world right here. The people that are called upon by other countries when things like this happen. We are ready to adapt and we’re ready to do whatever we have to as the disease spreads, if it spreads.

Donald Trump: (02:00)
As most of you know, the level that we’ve had in our country is very low. Those people are getting better, or we think that in almost all cases, the better they are getting. We have a total of 15. We took in some from Japan. You heard about that, because they are American citizens. They’re in quarantine, and they’re getting better too. But we felt we had an obligation to do that. It could have been as many as 42. It was just an obligation we felt that we had. We could have left them and that would have been very bad, very bad I think, American people. And they’re recovering. Of the 15 people, the original 15 as I call them, eight of them have returned to their homes, to stay in their homes until fully recovered. One is in the hospital, and five have fully recovered. One is we think, in pretty good shape and is in between hospital and going home. But we have a total of 15 people and they’re in a process of recovering, with some already having fully recovered.

Donald Trump: (03:23)
We started out by looking at certain things. We’ve been working with the Hill very, very carefully, very strongly. I think we have very good bipartisan spirit for money. We were asking for $2.5 billion, and we think that’s a lot. But the Democrats and I guess Senator Schumer, wants us to have much more than that. Normally in life, I’d say we’ll take it, we’ll take it. If they want to give more, we’ll do more. We’re going to spend whatever’s appropriate. Hopefully, we’re not going to have to spend so much, because we really think we’ve done a great job in keeping it down to a minimum. And again, we’ve had tremendous success. Tremendous success, beyond what people would have thought.

Donald Trump: (04:13)
Now at the same time, you do have some outbreaks in some countries. Italy and various countries are having some difficulty. China, you know about, where it started. I spoke with President Xi. We had a great talk. He’s working very hard. I have to say, he’s working very, very hard. If you can count on the reports coming out of China, that spread has gone down quite a bit. The infection seems to have gone down over the last two days. As opposed to getting larger, it’s actually gotten smaller. And one instance, where we think we can be somewhat reliable. It seems to have gotten quite a bit smaller. With respect to the money that’s being negotiated, they can do whatever they want. I mean, they can… We’ll do the two-and-a-half. We’re requesting two-and-a-half. Some Republicans would like us to get four, and some Democrats would like us to get eight-and-a-half. We’ll be satisfied, whatever it is. We’re bringing in a specialist, very highly regarded specialist tomorrow, who works actually at the State Department. Very, very tremendously talented in doing this.

Donald Trump: (05:26)
I want you to understand something that shocked me when I saw it. I spoke with Dr. Fauci on this and I was really amazed, and I think most people are amazed to hear it. The flu in our country kills from 25,000 people to 69,000 people a year. That was shocking to me. So far, if you look at what we have with the 15 people and they’re recovering, one is pretty sick, but hopefully we’ll recover. But the others are in great shape. But think of that. 25,000 to 69,000. Over the last 10 years, we’ve lost 360,000. These are people that have died from the flu, from what we call the flu. Hey, did you get your flu shot? That’s something. Now, what we’ve done is we’ve stopped non-U.S. citizens from coming into America from China. That was done very early on. We’re screening people, and we have been at a very high level. Screening people coming into the country from infected areas. We have in quarantine, those infected and those at risk. We have a lot of great quarantine facilities.

Donald Trump: (06:45)
We’re rapidly developing a vaccine and they can speak to you, the professionals can speak to you about that. The vaccine is coming along well. Speaking to the doctors, we think this is something that we can develop fairly rapidly, a vaccine for the future and coordinate with the support of our partners. We have great relationships with all of the countries that we’re talking about. Some, a fairly large number of countries. Some, it’s one person. Many countries have no problem whatsoever. And we’ll see what happens. But we’re very, very ready for this, for anything. Whether it’s going to be a breakout of larger proportions or whether or not we’re at that very low level, and we want to keep it that way. So we’re at the low level. As they get better, we take them off the list. So that we’re going to be pretty soon, at only five people. And we could be at just one or two people over the next short period of time. So we’ve had very good luck.

Donald Trump: (07:50)
Johns Hopkins, I guess, is a highly respected great place. They did a study, comprehensive. The countries best and worst prepared for an epidemic, and the United States is now… We’re rated number one. We’re rated number one for being prepared. This is a list of different countries. I don’t want to get in your way, especially since you do such a good job. This is a list of the different countries. United States is rated number one most prepared. United Kingdom, Netherlands, Australia, Canada, Thailand, Sweden, Denmark, South Korea, Finland. This is a list of the best rated countries in the world by Johns Hopkins.

Donald Trump: (08:40)
We’re doing something else that’s important to me, because he’s been terrific in many ways, but he’s also very good on healthcare. And we really followed him very closely, a lot of states do, when Mike was Governor, Mike Pence, of Indiana. They have established great healthcare. They have a great system there. A system that a lot of the other states have really looked to and changed their systems. They wanted to base it on the Indiana system, it’s very good. He’s really very expert at the field. And what I’ve done is, I’m going to be announcing exactly right now that I’m going to be putting our Vice President, Mike Pence in charge. And Mike will be working with the professionals and doctors and everybody else that’s working. The team is brilliant. I spent a lot of time with the team over the last couple of weeks, but they’re totally brilliant. And we’re doing really well. Mike is going to be in charge, and Mike will report back to me. But he’s got a certain talent for this. I’m going to ask Mike Pence to say a few words, please. Thank you. Mike.

Mike Pence: (09:50)
Thank you Mr. President. President Trump’s made clear from the first days of this administration, we have no higher priority than the safety, security, health and wellbeing of the American people. And from the first word of an outbreak of the coronavirus, the President took unprecedented steps to protect the American people from the spread of this disease. He recounted those briefly, but the establishment of travel restrictions, aggressive quarantine effort of Americans that are returning, the declaration of a public health emergency and establishing the White House corona task force, are all reflective of the urgency that the President has brought to a whole of government approach.

Mike Pence: (10:35)
As a former governor from the state where the first MERS case emerged in 2014, I know full well the importance of Presidential leadership, the importance of administration leadership, and the vital role of partnerships of state and local governments and health authorities in responding to the potential threat of dangerous infectious diseases.

Mike Pence: (11:05)
I look forward Mr. President, to serving in this role. I’m bringing together all the members of the corona task force that you’ve established. The HHS, CDC, DHS, the Department of Transportation and State. This team has been at your direction, Mr. President, meeting every day since it was established. My role will be to continue to bring that team together, to bring to the President the best options for action to see to the safety and wellbeing in healthy American people. I will also be continuing to reach out to governors, state and local officials. In fact, in the recent days, the White House met with over 40 state, county, and city health officials from over 30 states and territories to discuss how to respond to the potential threat of the coronavirus. We’ll be working with them in renewed ways to make sure they have the resources to be able to respond.

Mike Pence: (12:08)
And as the president said, we’ll be adding additional personnel here at the White House to support our efforts on the President’s behalf. We’ll also be working with members of Congress to ensure that the resources are available for this whole of government response. And we’ll be working very closely with Secretary Azar and his team, that have done an outstanding job communicating to the public to ensure the American people have the best information. With that, the President has asked me to recognize the Secretary of Health and Human Services, Alex Azar. And also, the Deputy Director of CDC, Dr. Anne Schuchat. Four of them, ops. Mr. Secretary.

Alex Azar: (12:52)
Thank you. Well, thank you Mr. Vice President. And thank you, Mr. President, for gathering your public health experts here today and for your strong leadership in keeping America safe. I just want to say, I could not be more delighted that you’ve asked the Vice President, my old friend and colleague, to lead this whole of government approach with us under the emergency support function number eight.

Alex Azar: (13:14)
As of today, we have 15 cases of Covid-19 that have been detected in the United States, with only one new case detected in the last two weeks. We also have three cases among Americans repatriated from Wuhan. And 42 cases among Americans repatriated, who had been stuck on the Diamond Princess in Japan. The President’s early and decisive actions including travel restrictions, have succeeded in buying us incredibly valuable time. This has helped us contain the spread of the virus, handle the cases that we have, and prepare for the possibility that we will need to mitigate broader spread of infections within the United States.

Alex Azar: (13:55)
The President’s actions taken with the strong support of his scientific advisors, have proven to be appropriate, wise and well calibrated to the situation. We’re grateful for the hard work that healthcare workers, first responders, communities and state and local leaders, have put into the response so far. Because of this hard work and the President’s leadership, the immediate risk to the American public has been and continues to be low.

Alex Azar: (14:21)
Our containment strategy has been working. At the same time, what every one of our experts and leaders have been saying for more than a month now, remains true. The degree of risk has the potential to change quickly, and we can expect to see more cases in the United States. That is why we’ve been reminding the American public and our state, local and private sector partners, that they should be aware of what a broader response would look like. CDC has recommended that the American public and especially state and local governments, businesses and other organizations, should refresh themselves on how they would respond in the event that the situation worsens.

Alex Azar: (15:02)
We’re encouraging Americans to learn what future steps might be necessary to keep themselves and their communities safe. Knowing these potential steps now can help keep the risk to you and your community low. Americans can find useful information at cdc.gov/covid, C-O-V-I-D, 19. And we’re working closely with government and private sector partners to educate them about preparedness.

Alex Azar: (15:28)
Finally, we’ve begun working with Congress to secure the funding that we need. There are five major priorities in the White House request to Congress, that the White House made on Monday. These priorities are first, expanding our surveillance network. Second, support for state and local governments work. Third and fourth, development of therapeutics and vaccines. And fifth, manufacturing and purchase of personal protective equipment, like gowns and masks. As chairman of the President’s coronavirus task force, I’m committed to providing regular updates from our coordinated inter agency process. We’ve had our top public health leaders like those joining me here today, speaking to the media many times per day to inform the American public.

Alex Azar: (16:14)
The Trump administration is going to continue to be aggressively transparent, keeping the American people and the media apprised of the situation, and what everyone can do. With that, I’m going to hand things over to Dr. Anne Schuchat. Dr. Schuchat is the senior career official at the Centers for Disease Control and Prevention, the Principal Deputy Director, with an over 30 year career at the CDC in public health, and as a member of the United States Public Health Service Commission Corps. So Dr. Schuchat, I’ll turn it over to you.

Dr. Anne Schuchat: (16:45)
Thanks so much, Mr. Secretary. As you know, this has been a difficult and challenging time. Our hearts go out to the individuals who have been directly affected by the virus, and to all those who have been working tirelessly in responding to it. Our aggressive containment strategy here in the United States has been working, and is responsible for the low levels of cases that we have so far. However, we do expect more cases, and this is a good time to prepare.

Dr. Anne Schuchat: (17:22)
As you heard, it’s the perfect time for businesses, healthcare systems, universities and schools, to look at their pandemic preparedness plans, dust them off and make sure that they are ready. And we have lots more information at the CDC’s website, and in partnership on how to do that. But it’s also a really good time for the American public to prepare, and for you to know what this means for you.

Dr. Anne Schuchat: (17:47)
The coronavirus that we’re talking about is a respiratory virus. It’s spread in a similar way to the common cold or to influenza. It’s spread through coughs and sneezes. So those everyday sensible measures that we tell people to do every year with the flu, are important here. Covering your cough, staying home when you’re sick, and washing your hands. Tried and true, not very exciting measures, but really important ways that you can prevent the spread of respiratory viruses.

Dr. Anne Schuchat: (18:26)
So the trajectory of what we’re looking at over the weeks and months ahead is very uncertain. But many of the steps that we have taken over the past 15 years to prepare for pandemic influenza and our experience going through the 2009 H1N1 pandemic of influenza, remind us of the kinds of steps that our healthcare system, our businesses, our communities and schools, may need to take. We’re in this together. All of government, the public and the private sector. And the CDC wants to make sure you have the best information available every day. Thank you.

Donald Trump: (19:05)
Please.

Dr. Tony Fauci: (19:12)
I just want to give you a very quick update on the-

Speaker 7: (19:14)
Name, please? Would you tell us your name, please?

Dr. Tony Fauci: (19:16)
My name is Dr. Tony Fauci. I’m the Director of the National Institute of Allergy and Infectious Diseases at NIH. Just a very quick update on the counter measure development in the form of vaccines and therapeutics. I had told this audience at a recent press briefing, that we have a number of vaccine candidates and one prototype.

Dr. Tony Fauci: (19:36)
I wanted to give you a feel for the timeframe of a vaccine, and what its impact might be now and in subsequent years… Is that I told you we would have a vaccine that we would be putting into trials to see if it’s safe. And if it induces a response, that you would predict would be protective in about three months. I think it’s going to be a little bit less than that. It’s probably going to be closer to two months. That would then take about three months to determine if it’s safe and immunogenic, which gives us six months. Then you graduate from a trial which is phase one of 45 people, to a trial that involves hundreds, if not low-thousands, of people to determine efficacy.

Dr. Tony Fauci: (20:16)
At the earliest, an efficacy trial would take an additional six to eight months. So although this is the fastest we have ever gone from a sequence of a virus to a trial, it still would not be any applicable to the epidemic unless we’d really wait about a year to a year-and-a-half. Now, that means two things. One, the answer to containing is public health measures. We can’t rely on a vaccine over the next several months to a year. However, if this virus which we have every reason to believe it is quite conceivable that it will happen, will go beyond just a season and come back and recycle next year. If that’s the case, we hope to have a vaccine.

Dr. Tony Fauci: (21:04)
And then finally and briefly, therapeutics. There are a number of antiviral drugs that are being tested. A few days ago, we initiated a randomized controlled trial of a drug called remdesivir, which has antiviral activity in vitro in an animal model. The good news about that, is that it’s a trial that’s randomized to either placebo or standard of care, and drug and standard of care. Which means, that we will know reasonably soon whether it works. And if it does, we will then have an effective therapy to distribute. Thank you.
 

Heliobas Disciple

TB Fanatic
President Trump referenced this chart in today's press conference so I thought I'd copy over the article where it was discussed, along with the graph he held up:


(fair use applies)

These are the countries best prepared for health emergencies
12 Feb 2020
David Elliott Senior Writer, Formative Content



The Global Health Security Index lists the countries best prepared for an epidemic or pandemic.
National health security is fundamentally weak around the world, it says, and nowhere is fully prepared to handle such an outbreak.
Global biological risks are in many cases growing faster than governments and science can keep up.
The international community must work together to ensure all countries are prepared to respond to these risks, it says.

Two years ago the director general of the World Health Organization silenced the audience at the World Government Summit with the view that a devastating epidemic could start in any country at any time – and that the world would not be prepared.

Today, with the globe in the grip of coronavirus, those comments seem even more prescient.

The current outbreak is nowhere near the scale of the situation Tedros Adhanom Ghebreyesus described to leaders at the Dubai summit, in which as many as 100 million people could die. But it has brought one question into sharp focus: just how prepared are we for a pandemic?

Not enough, according to the Global Health Security Index, a report from the Nuclear Threat Initiative, the Johns Hopkins Center for Health Security and the Economist Intelligence Unit released in October 2019.

The 195-country study finds national health security to be “fundamentally weak” around the world. No nation is fully prepared to handle an epidemic or pandemic, it says.

Which countries are best prepared?

The report uses public information to assess each country’s ability to prevent, detect and respond to health emergencies. The index measures countries’ capabilities from 0-100, with 100 representing the highest level of preparedness.
1.PNG

On this scale, the US is the “most prepared” nation (scoring 83.5), with the UK (77.9), the Netherlands (75.6), Australia (75.5) and Canada (75.3) behind it. Thailand and South Korea are the only countries outside of the West that rank in this category.

Much of Europe, Russia, the Middle East, Asia and Central and South America are described as “more prepared,” with scores between 66 and 34.3, while the majority of countries ranked “least prepared” are in Africa. North Korea (17.5), Somalia (16.6) and Equatorial Guinea (16.2) are listed in the index's bottom three.

China – which is at the centre of the recent coronavirus outbreak – is in 51st place, scoring 48.2.

What needs to be done?

Collectively, international preparedness is “very weak.” The index’s average overall score is 40.2, which rises to 51.9 for high-income countries – a situation the report describes as alarming.

So what can be done? The report emphasizes that health security is a collective responsibility.

It recommends governments commit to action to address health security risks, that every country’s health security capacity should be measured regularly and transparently, and that the international community works together to tackle biological threats, with a focus on financing and emergency response.

This kind of action will become even more necessary. The number and diversity of epidemic events has increased over the past 30 years, according to the World Economic Forum's Global Health Security: Epidemics Readiness Accelerator.

The trend is expected to intensify. As globalization brings increasing trade, travel and population density, and as problems such as deforestation and climate change grow, we enter a new era in the risk of epidemic events, it says.

Stronger, unified responses to these threats – such as that displayed by the Coalition for Epidemic Preparedness Innovations when it moved to rapidly form partnerships to develop a vaccine for the novel coronavirus – will be of vital importance.
 

Heliobas Disciple

TB Fanatic
(fair use applies)

Chinese woman without symptoms of coronavirus infects 5 relatives
February 22, 2020
TPE admin

A 20-year-old Chinese woman from Wuhan, the epicenter of the coronavirus outbreak, traveled 675 km north to Anyang where she infected five relatives, without ever showing signs of infection, Chinese scientists reported on Friday, offering new evidence that the virus can be spread asymptomatically.

The case study, published in the Journal of the American Medical Association, offered clues about how the coronavirus is spreading, and suggested why it may be difficult to stop.

“Scientists have been asking if you can have this infection and not be ill? The answer is apparently, yes,” said Dr. William Schaffner, an infectious disease expert at Vanderbilt University Medical Center, who was not involved in the study.

Researchers have reported sporadic accounts of individuals without any symptoms spreading the virus. What’s different in this study is that it offers a natural lab experiment of sorts, Schaffner said.

“You had this patient from Wuhan where the virus is, traveling to where the virus wasn’t. She remained asymptomatic and infected a bunch of family members and you had a group of physicians who immediately seized on the moment and tested everyone.”

According to the report by Dr. Meiyun Wang of the People’s Hospital of Zhengzhou University and colleagues, the woman traveled from Wuhan to Anyang on Jan. 10 and visited several relatives. When they started getting sick, doctors isolated the woman and tested her for coronavirus. Initially, the young woman tested negative for the virus, but a follow-up test was positive.

All five of her relatives developed COVID-19 pneumonia, but as of Feb. 11, the young woman still had not developed any symptoms, her chest CT remained normal and she had no fever, stomach or respiratory symptoms, such as cough or sore throat.


Scientists in the study said if the findings are replicated, “the prevention of COVID-19 infection could prove challenging.”

Key questions now, Schaffner said, are how often does this kind of transmission occur and when during the asymptomatic period does a person test positive for the virus.
 

Heliobas Disciple

TB Fanatic
(fair use applies)

Coronavirus far more likely than Sars to bond to human cells due to HIV-like mutation, scientists say
Stephen Chen in Beijing
Published: 12:30am, 27 Feb, 2020 | Updated: 1:32am, 27 Feb, 2020
  • Research by team from Nankai University shows new virus has mutated gene similar to those found in HIV and Ebola
  • Finding may help scientists understand how the infection spreads and where it came from

The new coronavirus has an HIV-like mutation that means its ability to bind with human cells could be up to 1,000 times as strong as the Sars virus, according to new research by scientists in China and Europe.

The discovery could help to explain not only how the infection has spread but also where it came from and how best to fight it.


Scientists showed that Sars (severe acute respiratory syndrome) entered the human body by binding with a receptor protein called ACE2 on a cell membrane. And some early studies suggested that the new coronavirus, which shares about 80 per cent of the genetic structure of Sars, might follow a similar path.

But the ACE2 protein does not exist in large quantities in healthy people, and this partly helped to limit the scale of the Sars outbreak of 2002-03, in which infected about 8,000 people around the world.

Other highly contagious viruses, including HIV and Ebola, target an enzyme called furin, which works as a protein activator in the human body. Many proteins are inactive or dormant when they are produced and have to be “cut” at specific points to activate their various functions.

When looking at the genome sequence of the new coronavirus, Professor Ruan Jishou and his team at Nankai University in Tianjin found a section of mutated genes that did not exist in Sars, but were similar to those found in HIV and Ebola.

“This finding suggests that 2019-nCoV [the new coronavirus] may be significantly different from the Sars coronavirus in the infection pathway,” the scientists said in a paper published this month on Chinaxiv.org, a platform used by the Chinese Academy of Sciences to release scientific research papers before they have been peer-reviewed.

“This virus may use the packing mechanisms of other viruses such as HIV.”

According to the study, the mutation can generate a structure known as a cleavage site in the new coronavirus’ spike protein.

The virus uses the outreaching spike protein to hook on to the host cell, but normally this protein is inactive. The cleavage site structure’s job is to trick the human furin protein, so it will cut and activate the spike protein and cause a “direct fusion” of the viral and cellular membranes.

Compared to the Sars’ way of entry, this binding method is “100 to 1,000 times” as efficient, according to the study.

Just two weeks after its release, the paper is already the most viewed ever on Chinarxiv.

In a follow-up study, a research team led by Professor Li Hua from Huazhong University of Science and Technology in Wuhan, Hubei province, confirmed Ruan’s findings.

The mutation could not be found in Sars, Mers or Bat-CoVRaTG13, a bat coronavirus that was considered the original source of the new coronavirus with 96 per cent similarity in genes, it said.

This could be “the reason why SARS-CoV-2 is more infectious than other coronaviruses”, Li wrote in a paper released on Chinarxiv on Sunday.

Meanwhile, a study by French scientist Etienne Decroly at Aix-Marseille University, which was published in the scientific journal Antiviral Research on February 10, also found a “furin-like cleavage site” that is absent in similar coronaviruses.

A researcher with the Beijing Institute of Microbiology, Chinese Academy of Sciences in Beijing, said the studies were all based on genetic sequencing.

“Whether [the virus] behaves as predicted will need other evidence including experiments,” said the researcher who asked not to be named.

“The answer will tell how the virus makes us ill,” he said.

Scientists’ understanding of the new coronavirus has changed dramatically over the past few months.

At first the virus was not considered a major threat, with the Chinese Centres for Disease Control and Prevention saying there was no evidence off human-to-human transmission.

But that assumption was soon invalidated, and as of Wednesday, there had been more than 81,000 confirmed infections around the world.

Chinese researchers said drugs targeting the furin enzyme could have the potential to hinder the virus’ replication in the human body. These include “a series of HIV-1 therapeutic drugs such as Indinavir, Tenofovir Alafenamide, Tenofovir Disoproxil and Dolutegravir and hepatitis C therapeutic drugs including Boceprevir and Telaprevir”, according to Li’s study. This suggestion is in line with reports by some Chinese doctors who self-administered HIV drugs after testing positive for the new coronavirus, but there is as yet no clinical evidence to support the theory.

There is also hope that the link to the furin enzyme could shed light on the virus’ evolutionary history before it made the jump to humans.

The mutation, which Ruan’s team described as an “unexpected insertion”, could come from many possible sources such as a coronavirus found in rats or even a species of avian flu.
 

Heliobas Disciple

TB Fanatic
(fair use applies)

Italian MOH Now Reports 400 COVID-19 Cases & 12 Deaths
Posted by Michael Coston at 1:10 PM
Wednesday, February 26, 2020

A week ago, Italy had only reported 3 COVID-19 cases, and - like many countries do today - assumed they had the situation under control. On Friday morning last week, they reported first 3 . . . and then a few hours later, 6 more cases.

Forty-eight hours later (Sunday) Italy declared an Emergency COVID-19 Decree Following 79 Cases & 2 Deaths. Towns were locked down, schools were closed, and the health department worked furiously to conduct contact tracing on cases.

Fast forward another 72 hours and the case count has risen to 400, with 12 deaths. We now know COVID-19 had been spreading - unnoticed - in Italy for 2 or 3 weeks at least. They didn't know about it, because they weren't actively looking for it in their community.

A cautionary tale of how quickly the COVID-19 situation can go from `contained' to a full blown crisis in a matter of hours. And proof that what you don't know, can hurt you.

The Italian MOH's 1600hrs (translated) update follows:

Covid-19, the cases in Italy at 6 pm on February 26th

400 people are infected with the new Sars-CoV-2 coronavirus in Italy. Of these 12 people died and 3 people recovered.

These are the official figures communicated today at the 18:00 conference by the Commissioner for the emergency of civil protection, Angelo Borrelli.

In the individual Regions the number of infected people is as follows:

Lombardy Region: 258

Veneto Region: 71

Emilia Romagna Region: 47

Piedmont Region: 3

Lazio: 3 (the 2 Chinese tourists and the resigned researcher)

Sicily: 3

Liguria: 11

Tuscany: 2

Brands: 1

Autonomous Province of Bolzano: 1

Of the swabs carried out 4% gave a positive result.

Watch the video with the point of the situation of 26 February at 6 pm of the Civil Protection
 

marsh

On TB every waking moment

Paying The Price For Our Faustian Bargain With China

Wed, 02/26/2020 - 18:45

Authored by Charles "Sam" Faddis via AndMagazine.com,
Roughly forty years ago we and the Chinese entered into a true Faustian bargain. We agreed to open our markets to Chinese goods, and the Chinese in exchange opened their nation to foreign investment and manufacturing.



We were motivated by greed. Factories in China would have access to seemingly unlimited quantities of low cost workers. It did not hurt that those factories would be unencumbered by unions, workplace safety laws or environmental regulations.

The Chinese were motivated by a desire to survive. The Soviet Union was tottering toward extinction, destroyed not by American forces on the battlefield but by rot and inefficiency in its economy. The Chinese would escape that fate by giving their people a higher standard of living and a more comfortable lifestyle in exchange for the continued acceptance of an oppressive, totalitarian regime.

The bargain was made. As with all pacts with the devil the bill has come due, this time in the form of the coronavirus.

Well over two months ago the coronavirus began to explode in China. The Chinese government did what it always does. It lied. It covered up the truth. It attacked those who claimed there was a serious problem and accused them of spreading disinformation and propaganda. On the internet, the Chinese deployed an army of bots, similar to those it used to bury the truth about protests in Hong Kong last year.

The Chinese had no choice. The continued existence of the Chinese Communist Party’s dictatorship is predicated on perpetual, explosive growth. Acknowledging the scope of what was happening would bring down the house of cards that had taken so long to construct.

Western observers, leaders and businessmen followed suit. They too believed they had no choice. They had bet everything on a system that made the entire global economy dependent on supply chains that seemingly all ran through mainland China. Contemplating what would happen if those supply chains suddenly stopped working was too awful. There was nothing to do but hope for the best.

As they say, hope is not a plan.

Today the stock market fell more than 1000 points on concerns that the coronavirus has so shut down the Chinese economy that many companies around the world will be unable to continue to supply consumers with products. Tech companies led the way, among them Apple, whose stock lost 5% of its value in a single day amid reports that the release of its new iPhone will have to be delayed due to virus related production problems in China.

The impact of factory shutdowns in China is already showing up here in the ports of Los Angeles and Long Beach – two of the busiest ports in the United States. Last year during the February – March timeframe there were a total of 17 cancellations of ship arrivals, largely due to the Lunar New Year. So far this year there have been 37 such cancellations.

The Port of Long Beach has seen cancellations skyrocket as well. In a typical year there may be 20 to 30 cancelled sailings. Already this year there have been 50. Noel Hacegaba, Deputy Executive Director of Administration and Operations at the port is crystal clear about the reason. It is, he said, “100% due to the factory closures” in China.

A ship docked at Long Beach on Friday of last week was the last one expected to come in from China for nine days.

Long Beach and Los Angeles are not exceptional. Many Chinese ports remain effectively closed. The number of cargo containers coming out of China each week has fallen by 300,000 since the virus hit. Worldwide the cost of shipping cargo is plummeting as ship owners compete for a rapidly diminishing amount of trade.

U.S. firms are already experiencing significant delays in getting shipments from China, but they are fortunate in the overall scheme of things. Given the distances involved, American companies have yet to experience the full force of shutdowns, because products were already in transit when the virus hit with full force. For a glimpse of the future, though, we need only look at South Korea.
South Korea’s giant Hyundai complex at Ulsan, the world’s biggest auto assembly facility, recently shut down. The complex, which includes five separate automobile plants and makes 1.4 million vehicles a year is offline, because it cannot get the critical parts it needs from China. Twenty-five thousand workers have been laid-off. Hyundai is not the only firm affected. Other major car companies in South Korea are either shutting down, limiting operations or considering doing so.

Here’s the real bad news. It is likely only going to get worse. The Chinese Communist Party has no choice. A citizenry out of work, out of money and faced with the truth that its government cannot combat the growing epidemic may finally revolt. The coronavirus is not just threatening lives. It is threatening the very existence of the regime.

So, in desperation, the Chinese government is forcing factories open and herding hundreds of millions of workers, many of whom were locked down and in isolation, back into the crowded dormitories where they live during the work year, half a dozen men or women to a room, using communal bathrooms and working on overcrowded factory floors. There could not possibly be a better petri dish environment to guarantee a disease – already defying all efforts to control it – explodes.

We made our deal with the devil. Like Faust the price we pay will be a terrible one.
 

Old Gray Mare

TB Fanatic
Fair use.

Six new nations announced they have their first Coronavirus cases. Updates on case numbers in a few other European countries. Most of countries in Europe have cases a few countries without cases don't appear to have been testing for it. Warning: language.

Coronavirus Update: Greece, Denmark, Romania, Pakistan, Macedonia, Estonia Cases: China Still Lying
•Feb 27, 2020



Styxhexenhammer666

411K subscribers
Link to source:
View: https://www.youtube.com/watch?v=UbLZL1jPPcY


runtime: 9:13
 

marsh

On TB every waking moment

McKinsey Publishes Handy 'How To Survive The Coronavirus' Guide For Corporations & Governments

Wed, 02/26/2020 - 17:55

Consulting firms - particularly the elite private firms like McKinsey and BCG - are supposed to earn their keep during crises, at least in theory. Aside from helping companies 'streamline' their operations (i.e. justify painful job cuts), it's really their only utility.

That's why we weren't surprised to learn that the only people on Earth who worked harder than the doctors and nurses in Wuhan over the past week have been the McKinsey marketing division, which managed to put together this colorful 'Crisis Response Report', a mix of widely-known information combined with some internal analysis, to try and drum up some business.

The report, entitled "Coronavirus COVID-19 Crisis Response" and dated Feb. 14, features a useful breakdown of where things stand (or at least where things stood a week and a half ago when they wrote the report), as well as a deck of slides explaining what McKinsey can do "for you" during this stressful time.




After reading the "executive summary", we can grasp the report's key takeaway: While China is expected to start ramping up production over the next week or two, it's possible that over the long term, we may see only a partial recovery. Because of this, companies need to start thinking about how to 'diversify' their supply chains. That's where the good people at McKinsey can help.

On the first slide, McKinsey started by explaining the history of coronaviruses, and where COVID-19 fits in, while also explaining that this is a "new" virus that has never infected humans before.



Slide No. 2 was dedicated to the topic of how the virus is transmitted, and how far it has spread. These charts are, of course, two weeks out of date, which means they're not really helpful other than reminding us how quickly the virus has spread.


Another (dated) roundup of the outbreak's "impact to date."


The chart below, about key factors that could influence the severity of the outbreak, is still useful.



Introducing, "the Chart that Dr. Tedros wants the world to see". The WHO director-general on Wednesday scolded governments and the press for using the word 'pandemic' in a way that sparks panic.


McKinsey's "base case" echos most of the Wall Street players: Right now, the consensus is for some of the economic impact to bleed into Q2, leaving open the possibility of a rebound in H2.



Here's a more detailed look at the potential fallout for the manufacturing sector.


Even though it's a little stale, this might be the most important chart in the deck.


This breakdown of some of China's most important factories is also helpful.



Again, McKinsey is taking some helpful travel data that we've seen before and presenting it in a handy visual.


For investors and business executives, McKinsey has created this handy 'coronavirus preparation' checklist.


The report also included some marketing materials for McKinsey, including information about the firm's work on previous outbreaks, while also introducing its "team of experts in epidemiology, crisis management, supply chain and stress testing."

But that material is a little too dry, so we figured we'd leave it out. However, if you're an anxious kleptocrat worried about whether a coronavirus outbreak could undermine your regime's grip on power, give McKinsey a call. They're good with that kind of ting.
 

Swamp Wallaby

International Observer
All schools in Japan told to close until April over virus outbreak

Kyodo, Staff Report

Prime Minister Shinzo Abe on Thursday asked all elementary, junior high and high schools nationwide to close from Monday through the students’ spring break, which typically ends in early April.

“Efforts have been made to prevent the spread of infection among children in each region, and these one or two weeks will be an extremely critical period,” Abe told a meeting of key Cabinet ministers on the coronavirus outbreak crisis.

“The government attaches the top priority to the health and safety of children, among others,” he said.

Abe’s surprise announcement came as the number of confirmed COVID-19 virus patients kept surging, exceeding 200 across Japan as of Thursday evening, excluding the more than 700 infected patients related to the virus-hit Diamond Princess cruise ship.

Most of the 1,600 elementary and junior high schools in Hokkaido decided to close for a week the same day in an effort to slow the ongoing coronavirus outbreak .

The action came a day after the Hokkaido education board urged local authorities to temporarily close all public and private elementary and junior high schools in an effort to contain the spread of the virus as over 50 infections have been confirmed in the prefecture, including some students.

“We will make our best efforts to prevent further spread of infection to protect the lives and health of the people in Hokkaido,” Gov. Naomichi Suzuki said during a prefectural assembly session.

Ochanomizu University in Tokyo had already said it will close affiliated schools from Friday for about a month until early April, including a spring break. Prince Hisahito, the 13-year-old nephew of Emperor Naruhito, attends the junior high school affiliated with the university. “I believe it is an unprecedented closure for such an extended period of time,” a school official said.

The Kanagawa government decided to exclude parents and guardians from attending graduation and entrance ceremonies at junior and senior high schools run by the prefecture as a precautionary measure.

Hokkaido’s capital Sapporo, which has about 300 elementary and junior high schools, will close from Friday through March 6.

“We wanted to secure enough time for working parents to arrange their schedules with their employers before starting the break,” said Masahide Hasegawa, chief of Sapporo’s education board, explaining the one-day delay in the closure compared with other schools in Hokkaido.

Machiko Inari, a 40-year-old resident of Hakodate, will take a week off to take care of her daughter, in fifth grade, and her son in kindergarten. “Although it will affect my work and coworkers, it’s better if it reduces the risk of infection for children as little is still known about the disease,” she said.

According to the Hokkaido education board, a health survey targeting all affected teachers will be conducted during the shutdown, while a decision to decontaminate school facilities will be determined by each municipality.

On March 5, a special class on infectious diseases will be held at all elementary and junior high schools in Hokkaido, and schools are expected to prepare for it during the closure.

High schools weren’t a part of the prefecture’s recommendation to close, and entrance exams for public high schools will be held on March 4 as scheduled.

The temporary closure is in line with central government guidelines that asked municipalities to consider calling off classes at all schools and closing down day care centers in areas where multiple virus cases are confirmed.In Tomakomai, where the infection of a female high school student has been confirmed, all elementary and junior high schools decided to shut down until March 8, longer than the request made by the prefectural education board.

In Ebetsu, where a junior high school teacher has tested positive for the virus, schools will be closed until March 6.

A series of infections at Hokkaido schools also include two brothers at an elementary school in Nakafurano and a school bus driver in Aibetsu.

 

marsh

On TB every waking moment
China's "Whatever It Takes" Moment (May Not Be Enough)

Wed, 02/26/2020 - 17:15

The COVID-19 outbreak is dealing a severe blow to China’s economy. Small- and medium-sized enterprises (SMEs) with tiny profit margins are especially bearing the brunt, but the impact is widespread, with the latest data point merely adding to concerns that, despite all the talk that Chinese are returning to work, the Chinese economy remains dead in the water.

As we detailed previously, here is China's daily coal consumption which have barely pushed off the lows, and are roughly 50% where they were a year ago this time.



With coal demand in the doldrums, it is also to be expected that coal supply is depressed as well, and indeed coal volumes over the past week remain 25% lower than the past 3 years' average, and roughly 33% below the 2019 level.



One of the better indicators of real-time commerce, traffic congestion, remains virtually unchanged, and substantially below where it was in previous years.



Yet, hilariously, this being China even with no transport, no commerce, and virtually no power plant use, pollution is finally starting to ramp up. One wonders what is causing this if it's not coal demand, or transportation: maybe all those crematoriums working overtime?



And speaking of not transport, the number of passengers carried after the New Year is barely above 10 million, almost 50 million below last year's levels.



Meanwhile, a brief silver lining in the economy was promptly snuffed out last week, when the property sales volume in 30 major cities crashed back to earth and remains well below 25% of the seasonal norm.



And with no end market demand, it is hardly a surprise that steel demand has continued to crater, and was below half the normal level from the past 3 years, with the most recent data showing full-country apparent steel demand -33% y/y vs -43% y/y last week:
  • Construction steel -78% y/y (in line with physical steel trading volume)
  • Flats -16% y/y


Last but not least, and perhaps most ominous of all, the earlier semi-official data print in the form of the February survey on business conditions showed a depression level plunge, with the index crashing more than 18 points, the most on record, to 37.3, which confirms Nomura's expectation of a manufacturing PMI print later this week which may have a 30-handle.


And so it is little wonder that China just went all-in on monetary and fiscal support for the nations' companies, following Mario Draghi's lesson -
"whatever it takes."
As Nomura's Ting Lu details, to cope with this substantial shock, China’s State Council on 25 February unveiled a raft of targeted policy measures to support SMEs, especially those in Hubei province, the epicenter of COVID-19 (but, while more measures are coming, Nomura does not see “massive stimulus” as imminent, something we warned about two weeks ago)

This is in line with our view that Beijing is keenly focused on helping SMEs survive the epidemic and pushing for business resumption.

Following the containment of COVID-19, we expect Beijing to taper off these easing measures in part to tame inflation and other issues amid an expected V-shaped recovery.

We do not expect Beijing to launch a round of significant stimulus packages to boost investment and consumption demand following the epidemic.
Beijing’s package to rescue SMEs amid the virus outbreak

Policy measures in the package include targeted liquidity and credit support, targeted tax cuts, targeted cost cuts and rental cuts. Details follow below:
  • On targeted liquidity support, the PBoC will increase the quota for banks regarding relending and re-discounting by RMB500bn to extend credit to SMEs, following the PBoC’s RMB300bn special-purpose relending (with a proportion of interest covered by fiscal subsidies) in early February. It will also lower the interest rate of re-lending designated for agricultural entities and SMEs by 25bp to 2.5% pa. According to the PBoC, as of end-2019, the outstanding amount of re-lending designated for agricultural entities and SMEs was RMB260bn and RMB283bn, respectively.
  • On targeted credit supply, Beijing encouraged financial institutions to provide a grace period for the virus-hit SMEs, upon application, in repaying the principal and interest of their outstanding loans, with the repayment date postponed to as late as 30 June and penalty interest waived; the policy applies to all companies in Hubei province. Beijing further required state-owned large commercial banks to achieve a 30% y-o-y growth in their outstanding loans to SMEs in H1, and lower the loan rates for SMEs from the level in the previous year. Policy banks will receive a special quota of RMB350bn for extending cheap credit to SMEs and the private sector.
  • On targeted tax cuts, the value-added tax (VAT) will be exempted for small-scale taxpayers in Hubei province between 1 March and end-May, while the VAT rate for small-scale taxpayers outside Hubei province will be lowered from 3% to 1% over the same period.
  • In addition, Beijing pledged a forceful implementation of lowering electricity prices for industrial and commercial businesses (excluding high energy-consuming industries) by 5%, and encouraged local governments to reduce urban land use taxes to support landlords’ rent cuts for individual businesses.
We expect more policy easing measures...

As COVID-19 is not yet under control and business resumption continues at a slow pace, most SMEs have been severely hit. We expect Beijing to further ramp up its policy support for SMEs and low-income individuals. We also expect some other easing measures in coming months to boost final demand and stabilise market sentiments:
  • We continue to expect Beijing to provide local governments with more flexibility in easing some tightening measures in their local property markets. In recent days a few banks have reportedly eased their minimum downpayment ratios for new home purchases in some cities. However, we think it unlikely that Beijing will launch another round of big stimulus packages to boost nationwide property demand like it did in H2 2015 after the stock market crisis.
  • We expect Beijing to ramp up investment in infrastructure during and after the fight against the virus, but the scale is unlikely to be massive owing to tight financial and fiscal conditions.
  • We expect Beijing to roll out some policy stimulus measures to stabilise auto sales, such as cutting auto purchase taxes, encouraging more cities to ease quota restrictions on vehicle licenses, and providing subsidies for the replacement of old cars.
...but as we detailed previously, a massive stimulus seems less likely



However, it seems unlikely that Beijing will roll out another big round of stimulus packages because:
1) the room for policy space is limited after years of stimulus and rapid accumulation of debt;
2) current account balance is worsening while foreign debt is on a rise;
3) CPI inflation may remain elevated above 5% y-o-y in H1;
4) conventional stimulus to boost investment and consumption demand may not work well amid the virus outbreak;
5) we expect a natural V-shaped recovery following the containment of the epidemic, thus adding too much stimulus could lead to an overheating. After the containment of COVID19, we expect Beijing to gradually taper off some easing measures, with no repeat of the RMB3.6trn of the PBoC’s pledged supplementary lending (PSL) money, which was used for the property sector in low-tier cities between 2015 and 2019.
* * *
And so, while Goldman continues to believe that Chinese investors will look through weak current demand due to Xi’s policy put.
The question is - what's already priced in for Chinese markets? It appears a lot...



One glance at the chart above and it's clear that the support for Chinese stocks has been unprecedented.


And all driven by re-leveraging!!??

That can't end well, no matter what Xi says or does. However, as Goldman suggests, in its always-a-silver-lining manner, "we know demand is bad now, it’s the 2nd derivative that matters."

But, as we noted earlier and Nomura confirms, markets may be significantly disappointed as "big stimulus" is more than priced in... and is likely to be absent from CCP policy statements as they try to juice confidence through fabricated case/death counts.
 

marsh

On TB every waking moment

The End Of The Beginning Or The Beginning Of The End?
Profile picture for user Tyler Durden
by Tyler Durden
Wed, 02/26/2020 - 16:25

Authored by Ryan Selkis via Messari.io,
I don’t consider myself superstitious or paranoid, but this past week I've had a rare combination of bad omens, sleepless nights (I *never* have sleep issues), and intuitions that have left me convinced we may truly be at the cusp of “The Fourth Turning” - a sort of generational reset - where the coronavirus serves as the catalyst that sparks mass societal changes which were already in motion thanks to federal government dysfunction, never ending global monetary stimulus, and declines in traditional media.


The Fourth Turning in Strauss-Howe's generational theory, or the “Crisis”, is an “an era of destruction, often involving war or revolution, in which institutional life is destroyed and rebuilt in response to a perceived threat to the nation's survival. After the crisis, civic authority revives, cultural expression redirects towards community purpose, and people begin to locate themselves as members of a larger group."

I’ll concede there is probably a heavy confirmation bias in paying any attention to Strauss-Howe, given that those who have already gravitated to crypto are much more likely to hold deep personal levels of distrust in our institutions. Still, I find the model a bit eerie in its predictive power given it was proposed 20 years ago. Though it was (is?) derided as pseudo-science by scholars, I find it worth reading up on.

The trillion dollar macro question seems to be whether we are at the "beginning of the end” or the "end of the beginning” of this Fourth Turning, a trite way of considering whether and how big global events like elections, terrorist attacks or wars, massive technological breakthroughs, pandemics, etc. will spark much bigger changes beyond their local peaks. In other words, is a given event a black swan or an expected event in the natural course of history? When it comes to the coronavirus, I tend to think the black swan is not the emergence of a pandemic, but the second and third order effects the virus could have on global politics and trade.

My logic runs as follows:

  1. Compared to the seasonal flu, the coronavirus is more contagious, deadlier, harder to contain, takes up more critical medical resources, and has a longer asymptomatic infection period. It has no effective vaccine / treatment, and can infect entire populations in close quarters (families, hospitals, Diamond Princess, etc.) So if containment efforts fail, the virus will overwhelm global healthcare systems.
  2. The key variables I’m tracking (with best guess assumptions) is that the virulence (R0) is 2-3x worse than the flu, 5-15x deadlier, more quietly contagious, and leads to a much higher percentage (20%) of critical medical events.
  3. Extrapolations are dangerous, but these variables suggest there could be tens of millions of potential deaths and a complete overrun of most critical care in global healthcare systems. Barring some miraculous disappearance of the virus (or new data), we might expect to see aggressive containment measures with massive economic ripple effects.
  4. In a world where ~60 million people die every year, 10-20 million deaths sounds scary, but it’s really a short-term blip in mortality. The real devastating impact will be felt throughout the global economy, where a rise in nationalism / populism / isolationism, meets escalating trade wars, meets a virus that tests the resilience of interconnected supply chains on an unprecedented scale.
  5. We're already starting to see multiple glimpses of the potential economic contagion, and I have kept a running tally in my document on the virus here.
I’ve written about this virus with such obsession and urgency over the past several weeks, not because I’m afraid the sky is falling, and we're all screwed, but because I remain optimistic about whatever comes next even if the worst case comes to pass.

It is easy to get fearful (or dismissive) about the idea something like the coronavirus could lead to a global reset, and to mock the prophets of doom.
It is harder, but more important to prepare for, embrace, and work towards the second phase of the Fourth Turning: the post crisis revival of civic authority, cultural embrace of community, and the rally around a globally common purpose and identity.

If things get worse and we go into a prolonged period of self-isolation, what role will crypto pioneers (who have the luxury of working remotely) play in building a more resilient economy and post-crisis future?

I hope it's more meaningful than mere speculative games.

It may have to be if crypto is to survive a global recession.



Today also happens to coincide with the sixth anniversary of the Mt. Gox bankruptcy, one of the most stressful events of my life/career.

I break down the full play-by-play on Charlie Shrem’s newest podcast, including how I got my hands on the fateful “crisis strategy draft” smoking gun document; broke the story; then went to war with skeptics, trolls, and the Bitcoin Foundation for falling asleep at the wheel with respect to warning the community about the Japanese exchange’s problems.

It was fun to recount the full tale, and it’s a timely reminder that things don’t always end up as bad as you think they might: I sold all of my bitcoins after breaking the story out of fear the event would prove existentially bad for bitcoin.

But the Mt. Gox saga turned out to be the end of the beginning. Not the beginning of the end.

I hope I am wrong about the coronavirus in exactly the opposite way: that containment measures are working, that it turns out we are at the beginning of the end of this outbreak, and that we'll mostly return to normalcy in a matter of weeks or months. We’ll see.
 

marsh

On TB every waking moment
Rabobank: We Simply Don’t Have Enough Hospitals Or ICU Units Anywhere

Wed, 02/26/2020 - 14:55

Submitted by Michael Every of Rabobank
Markets have finally woken up to the threats being presented by COVID-19, which comes on top of what was hardly a healthy global economy. Yesterday saw the S&P down a further 3% to 3,128 and the Dow down 3.1% to leave us close to the “27,000!” base-ball cap level. At the same time we hit new record lows in US Treasury yields. The 10-year touched 1.31%, although this morning we have seen yields backing up again to 1.37%, while the 30-year hit 1.79% and is now at 1.85%. FX markets were somewhat less phased, for once, with EUR/USD still over 1.0860, AUD/USD holding over 0.66, GBP/USD around 1.30, USD/CNY around 7.03, and even USD/JPY around 110.50.

Not waking up so much is the White House. “All is well!” is the tweeted message from the president, when he isn’t busy talking about the US justice system in what can be seen as worrying detail given that little thing called separation of powers. White House economic advisor Larry Kudlow went even further: “We have contained this. I won’t say airtight, but it’s pretty close to airtight,” he said, adding while the outbreak is a “human tragedy” it will likely not be an “economic tragedy” and “At the moment…there’s no supply disruptions out there yet.

Markets seem to disagree. So does the US Centre for Disease Control (CDC), which has stated that it is when and not if COVID-19 hits the States. Of course, if you aren’t testing people you aren’t going to be finding any cases - and there is not a whole lot of testing going on in the US right now.

Indeed, the WHO--who still won’t call it a pandemic, which would be a major ‘event’ trigger--are saying that the globe is “simply not ready”. And they are right: imagine the strain on health services even in developed countries if COVID019 were to sweep in, especially with up to 20% of the population aged over 65 and hence most vulnerable based on the observed mortality pattern so far. We simply don’t have enough hospitals or ICU units anywhere.

Yet at time of writing there were further signs that the virus continues to spread, even if within China the data is pointing in the right direction (this being the one the data-providers want to see: note that Caixin is today saying that in one sample 14% of recovered virus patients in Guangdong tested positive when checked up again, and hence may still be infectious). Elsewhere, we have many more cases and a few more deaths in Italy; a case in Germany near the Dutch border linked to Italy; a case in Austria, and in Croatia; 1,000 people quarantined in a hotel in Spain, again linked to Italy; 169 new cases in South Korea, even despite a draconian lockdown; a US solder in South Korea testing positive, risking infection within the US army; a Korean airline stewardess who may have spread the virus in many locations; suspicions of infections stemming from Bali, where there is also not a lot of testing going on; and cases right across the Middle East, including the Iranian deputy health minister, who could recently be seen sweating profusely--maskless--in a televised public health announcement telling the public “All is well!“; and what looks like a case in Brazil, the first recorded in Latin America.

Economically, the “anti-Kudlow” argument, or the “Kud-LOW” argument is even clearer: Guangdong is keeping schools closed until 2 March, and Hong Kong until 20 April (ouch!); Virgin has cancelled all flights from Australia to Hong Kong; Kuwait has cancelled all flights to Singapore and South Korea; China is freezing some flights to South Korea too; and other global-connectivity threads are being snipped away one by one. There is even muttering that the Olympics is under threat as Japan closes down major public events “for the next two weeks”.

This is all as the WHO and the EU keep insisting that nothing and nobody should interfere with free movement of goods and people across borders, presumably for fear of setting a precedent for anti-globalization forces…who will equally naturally be making political hay from the establishment’s inability to apply standards consistently, this time on quarantine:
within national borders completely draconian measures are laudable - with reports on social media alleging that some Chinese firms are even micromanaging where and when workers go during the day, for example. Expect that inconsistency to change in just one direction. The clamour will be for international lockdowns as well as local in the same way that while it was fine to provide unlimited liquidity to banks and nothing at all to the public a few years ago, the current trend is now to provide unlimited liquidity to banks and public money to the public too.

On which note, battered Hong Kong has just announced it will be electronically handing over HKD10,000 (USD1,274) to each of its adult permanent residents in an attempt to try to juice the collapsing economy. Yes, the special administrative region sits on vast fiscal reserves that it usually does nothing useful with other than white elephants and tax rebates. No, this won’t help an economy much when nobody is going out or coming to visit. Yes, it’s ironic that the first location to go the helicopter money route doesn’t even have an endogenous sovereign currency given HKD is pegged to the USD. Imagine how fiscally creative a country that CAN run MMT policies could get in the face of the virus threat. Indeed, recall China has in many ways been doing this quasi-MMT thing for years if you consider the IMF’s estimate of a consolidated fiscal deficit of 12% of GDP even before this crisis started. This is why it cannot afford to run a trade deficit, exposing its currency to the downside of such an ‘MMT-like’ policy. Yet a flood of foreign firms leaving the country due to this virus is going to make that more, not less, likely ahead - as is the fear that Beijing will increase central control over the economy once the dust has finally settled. As mentioned earlier, USD/CNY is still not that Kud-LOW at around 7.03. Think how low global bond yields will go when this hits home and it’s trading nearer to 8.
 

marsh

On TB every waking moment

Covid-19 Is Fast Exposing The Market's Reality...

Wed, 02/26/2020 - 13:35

Authored by Bill Blain via MorningPorridge.com,
“Failure is not falling down, but not getting back up again..”
Someone important in the Hong Kong Government reads the Morning Porridge! Last week I was talking about the use of “Helicopter Money” as a policy response; dropping wads of cash direct to consumers to juice the demand side of the economy – and this morning the HK authorities announced a HK$ 10k handout to each and every citizen!

Back in London, I’ve heard staff were sent home from the London office of a top-rank US investment bank because their spouses had attended the Milan Fashion Week. They’ve been told to go into self-imposed quarantine. The Irish govt has called for the cancelation of the Ireland vs Italy game. Two meetings on one of my deals next week have been switched to less effective conference calls because key staff may be unwilling to travel to Yoorp from the US. It looks like my annual Lads Ski Trip to the top of the Aosta Valley in 10-days time is unlikely to go ahead.

Dang. Covid19 is becoming dashed inconvenient...

The market reality is becoming... fraught. By the end of this week its entirely likely markets will be down 10% or more from last week’s top (currently 7.5% down and watching!) That’s serious. But, what’s scary is that this crash is utterly different to anything that’s gone before... This is outside our normal experience.
Yesterday’s market was like watching Homer Simpson tumbling down a steep slope. He bounced off a ledge, rose higher for a moment, before gravity inevitably took over. Doh! Will the market stop tumbling today? Probably not – the trend is further economic, virus triggered, reactive slowdown. But, this is not a conventional end-of-the-world-as-we-know it stock death plunge. This is a slow-motion catastrophe as shocked realisation bites; where the reality of the virus induced snap recession and its consequences will continue to depart from the path of a conventional crash.

The upside of this slo-mo crisis is it gives market participants more time to think and react – which equally means more opportunity to get it horribly wrong!

This is going to prove a new experience for everyone. Most crashes, and this is my 6th or 7th since my first in 1987, see the whole market tumble in lockstep. This crash is going to be more about unknown coronavirus-driven fundamentals – which sectors and names are most vulnerable to broken supply chains, permanently lost orders, travel lockdown and industrial siege mentality, and which are most likely to benefit from critical sector government support.
It’s also the subject of an exogenous force – the unknowns about the virus. This will be driven by how governments react to an external pandemic threat rather than the usual internal crisis vectors like stupidly unwise bank lending, or a stock bubble bursting (although it doesn’t help the valuation bubble looked very close to popping!) The effect is the tempo of the crisis will rise and fall dependant on the non-economic factors – the spread (contagion) and effect (mortality) of the disease.

Someone will suggest can probably write that as a formula:
P = f{(C*Ci/1/M*(CP)})*G

Where Panic (P) is a function of Contagion (C ) * the increase in Contagion rate (Ci) / Mortality (M) * 1/Cured Patients (CP) multiplied by the Government (G) factor on whether policy is good/bad .. or something like that…

Problem is… none of us in markets are experts on pandemics – hence we’re as likely to be wrong as anyone. Industry talking-heads pretending they understand the virus are likely to be as wrong as anyone.

Take it for granted that the experts advising governments on lockdown are experts, and while they might not know all about it, they know more than us...
That’s a reason to be worried. The crisis, the disease, has only just burst out of China, and as it explodes elsewhere the shock effect on market sentiment has already been massive – perhaps out of all proportion – or so say a number of market pundits. As the pace of cases rises and falls, deaths occur, treatments and cures are found, and we see more reaction from the authorities, then the likelihood for sustained market volatility increases. See my formula above.

The slo-mo crisis gives time to make investment calls. I’ve said before I’m not so worried about solid names like Apple – if you can’t buy an iPhone today, you will be able to buy one in a few weeks, months, next year. I was tempted to buy Spotify and Netflix, till figuring that if people are bored in quarantine skimming through Spotify, then it actually has to pay more in Royalties if more people are streaming content! (Which might be a good reason to buy Music as Asset (guess what? I’m doing a Music deal at the moment!)

Maybe sell Italy bonds and banks? A cancelled ski trip means resorts at the head of the Aosta – Courmayer and La Thuile (my favourite ski destination) - will effectively close, with multiplier effects down the Valley. I’ve seen the effects of a bad winter before: the following year there are shuttered restaurants, skimped piste maintenance, and older skis in the hire shop. Cancel the whole season a month early – and you are talking a whole regional economic ecosystem in trouble.

It’s entirely possible restrictions in global travel will push the more vulnerable airlines into default – although it’s also predictable governments will step into support them. That’s a market call – which airlines have enough government clout and support to sustain them through a lean period? Norwegian will be one to watch. And how much pressure will bailing out a Middle East national carrier create when the underlying economy depends on the oil price – which has been pummelled by uncertainty on virus slowdown, and the strained Saudi/Russian relationship?

Spread that analysis out over every sector of the whole economy. The Chinese are trying to do it by mandating no layoffs, and telling the banks to lend and assuring them they will be bailed. (That’s a whole can of unintended consequential worms in terms of possible banking behaviour…) Western economies might have to make similar calls.

The closest parallel I can think of is the organisation and management of a wartime economy. There are some fascinating histories comparing the success of the UK coalition government directing the economy through 1940-1945, compared to the undirected dither, competitive powerplays and wastage within the German Reich – most folk will be entirely unaware how badly the German economy failed to adapt, and why it’s a major and often understated reason they lost the last global conflict.

Meanwhile…

While all eyes are focused on where markets are going in response to the Cataclysm of Coronavirus news.. there is plenty else bubbling down below on the front lines of finance:

Another emerging market debacle is unfolding in Lebanon, US company downgrades as unwise leverage and M&A raising the ire of rating agencies are rising, the Democrats self-immolating in the US, and the doubts about politicians eyeing each other to see who might try to garner a boost from the current virus fixated market. (A bit of competitive devaluation anyone?)Or how about story in FT this morning about the rise of hydrogen – which has enormous implications for the hype over electric cars!

In short, there is plenty to think about out there aside from the darn virus! When you need something to not understand, let’s move on to Europe.

The big issue is the UK trade agreement. Yesterday the Yooropeens agreed that Britain must be punished for Brexit. If we want to trade with Europe, it can only be if we accept every rule of the EU. Does anyone outside Brussels understands that’s going to trigger crisis? The UK will not accept it.

Strip it down to the basics, and it feels like we’ve got a continuation of the 1000 year war. It’s not about protecting the Yoorpeen Union from a more nimble and more perfidious Albion undercutting its trade and good standards. It’s about France getting payback time. The smart economic outcome for Europe would be a good trade deal with the UK, where the damage to the Union is minimised and trade carries on as before. Instead, the French won the argument, together with their salivating Irish poodle. They want to humiliate us, choosing their moment as a distracted and senile Germany snores in the background, to make its play.
That’s a bad decision. As M. Barnier struts the stage of history demanding Britons submit as slaves to the Franco-Yooropean hegemony… our politicians will not dither or shilly-shally, but make a very clear guesture to Europe in terms of access to British fish, thus stoking a future of on-going trade protectionism. The default position from angry right-wing Brits will be simple: Europe is very welcome to our fish – they can buy all the fish they want at whatever the market price is from British trawlers. We might be willing to do a few side deals in return for some consideration. If you want the best fish in Europe – it’s going to cost. It will cost more in France.

That won’t be good for anyone.

Listening to calm reasonable European parliamentarians a few weeks ago it sounded like a negotiation likely to result in a sensible Canada style deal was underway.

Now, the UK has to circumvent the French dominance of the hollow EU. Boris and his gang need to deliver messages direct to European leaders telling them the UK is not even going entertain France’s demands. Let’s start again and let it be widely known we are willing to sign up to the agreed Canada style deal with Europe, and negotiate from there. If they refuse, as they have been mandated to do, lets break the rules.

Let it also be know we’re more than willing to strike side deals with each European state – except for France and Ireland – on everything and anything. The Spanish want our Fish? No problem. The Germans want to sell us their cars? No problem. The Danes want to sell us Bacon? No problem. Let’s chat.
Now I know that isn’t possible when dealing with the Yoorp trade monolith – where one size fits all, but France better. Its time to let European voters know what a trade block with the UK will cost. Let the national press, farmers, fishermen, the Eurosceptics and the right wing know, and reinforce the message that France’s singular desire to hurt perfidious Albion can only be achieved by crushing German, Dutch, Danish, Swedish and the rest of Yoorp’s exports.
The French have tried to mount economic blockades of Britain before. Didn’t take rest of Europe long to work out dealing with a merchantile trading economy like the UK beats dealing with the dead hand of French state policy every time.
 

Squid

Veteran Member
Even with the media picking up on this may be serious and since the left see’s this as a strategy to take down Trump you still have a window to prepare. The media to support the the Trump take down will attempt to induce panic but for now the prep window is open.

Might be a good idea to think through your buying timeline, get the sheeple stuff now and when they all go black friday to get milk and bread, and fights break out over the last dudt mask (you can forget N95) either chill at home or be topping off gas and get some electronics before supply shortages hit those.
 

marsh

On TB every waking moment
Trump Furious With CDC For 'Spooking' Market: WaPo

Wed, 02/26/2020 - 11:55

President Trump's penchant for viewing the stock market's performance as a barometer of his presidency's success is widely known to the public by now. So the fact that Trump has been extremely agitated by goings-on back home during his trip to India this week is hardly a surprise.



Usually, we don't give much credence to the Washington Post's inside-baseball stories purporting to offer a 'peak behind the curtain' while creating a venue for vindictive officials to exact their revenge by anonymously trashing the president or rivals within the administration.

But today, WaPo's account basically confirms what we suspect has been unfolding behind the scenes, with the president turning on yet another federal agency and blaming it for spooking the markets. In the past, Trump has (either publicly or privately) blamed Democrats, Treasury Secretary Mnuchin, Labor Secretary Wilbur Ross, Boeing and - of course - Jay Powell for the market selloffs.

Now, we can add the CDC to that list.

The paragraph below is basically the heart of WaPo's story, describing President Trump's impotent fury at helplessly observing the selloff from afar.
While he has spent the past two days traveling in India, Trump has watched the stock market’s fall closely and believes extreme warnings from the Centers for Disease Control and Prevention have spooked investors, the aides said. Some White House officials have been unhappy with how Health and Human Services Secretary Alex Azar has handled the situation, they said.
Specifically, Trump was furious at the CDC for its press conference on Tuesday which appeared to rattle the market and cemented the selloff for a fourth day. The No. 1 rule for successful propaganda is to make sure your source still appears credible to the unengaged reader or viewer. When one insists on pushing a narrative that is completely divergent from the lived experience of millions, credibility can be damaged.

"You don’t want to overly feed the darkness, but if you seem like all you do is happy talk then you lose credibility," said Gene Sperling, who served as a top economic adviser during the Clinton and Obama administrations. "You get a three-hour high from your happy talk, but lose the long-term ability to be seen as serious, factual and potentially reassuring at a later point when it might be justified. This White House may already be in danger of losing the capacity to be seen as serious."
Just like the State Department's decision to bring back 14 infected Americans during their evacuation of the 'Diamond Princess', the administration's approach has left it open to criticism - at least, according to the Washington Post.
Now, White House officials’ efforts to contain the economic fallout from the coronavirus have created new political hazards, as they publicly play down the threat while other federal officials with a background in health and diseases are warning of more severe consequences for inaction. The administration also risks creating new health hazards, should the pressure to assure investors of economic stability undercut its public health message about the mounting threat.
In a statement, the White House defended its response, saying comments have been taken out of context or twisted to distract from the Trump administration’s efforts so far. Administration officials strongly denied that the CDC and White House economic team were at odds on Tuesday.
At least one analyst appeared to agree.
"The CDC is probably more credible about the risks from the coronavirus than anything the Trump economic officials say," said Chris Rupkey, chief financial economist at MUFG Union Bank. "The market is coming down on the CDC."
On CNBC, guests complained that the administration's message sounded muddled and confused yesterday, which certainly didn't help boost the market's confidence. Fortunately for investors, the administration has refined its message, as Kudlow and others insisted that Trump's warnings represent "where we are now", while the CDC is focused on staving off the worst-case scenario.

A snippet from Kudlow's appearance on CNBC yesterday is one example:
"We have to err on the side of emergency planning in the United States. They are doing the right thing," Kudlow said of CDC officials. "I have to worry about the economy and the financial markets ... There’s a fear factor right now, and I get that, but what I was trying to say is this thing is not going to go on forever, and our economy is in great shape."
The White House also blamed Democrats and accused them of trying to deliberately trying to scare markets in an effort to sabotage Trump.
"Unfortunately what we are seeing today is a political effort by the Left and some in the media to distract and disturb the American people with fearful rhetoric and palace intrigue," White House spokesman Judd Deere said in a statement.

"The United States economy is the strongest in the world thanks to the leadership and policies of President Trump. The virus remains low risk domestically because of the containment actions taken by this Administration since the first of the year."
And let's not forget the Dems media allies.

President Trump initially dismissed the virus during his trip to Davos in January, and has issued a string of optimistic tweets this week, including encouraging investors to 'buy the f--king dip' on Monday. Unfortunately, those who took the president's advice probably got smoked.

With more than 50 cases confirmed in the US and the CDC warning about imminent community outbreaks, Trump's words can sound jarring. But remember: The better prepared everyone is, the less likely the virus will spread. And nothing inspires this type of behavior quite as effectively as genuine paranoia.

The only problem is, it will take time before we know for sure whether the Trump Administration's travel restrictions were effective.

Trump will address the outbreak at 6 pm ET. Watch it live here.

Meanwhile, before we go, we'd like to point out another angle that was unsurprisingly overlooked by WaPo: the CDC's Dr. Nancy Messonnier is the sister of the former Deputy Attorney General Rod Rosenstein, the one who appointed Special Counsel Robert Mueller and was eventually fired by President Trump following a tense overall tenure.

Is it possible she could be part of the resistance?

Also, as we've pointed out previously, the CDC's diagnostic tests have malfunctioned and only a few states and local health agencies have any tests on hand.

Is Trump being set up?
 

marsh

On TB every waking moment

Updated February 26, 2020
CDC is closely monitoring an outbreak of respiratory illness caused by a novel (new) coronavirus. The outbreak first started in Wuhan, China, but cases have been identified in a growing number of other international locations, including the United States. This page will be updated regularly on Mondays, Wednesdays, and Fridays.
COVID-19: Confirmed Cases in the United States*†
COVID-19: Confirmed Cases in the United States*†
Travel-related12
Person-to-person spread2
Total confirmed cases14
Total tested445
* This table represents cases detected and tested in the United States through U.S. public health surveillance systems since January 21, 2020. It does not include people who returned to the U.S. via State Department-chartered flights.
† Numbers closed out at 4 p.m. the day before reporting.
COVID-19: Cases among Persons Repatriated to the United States†
COVID-19: Cases among Persons Repatriated to the United States†
Wuhan, ChinaDiamond Princess Cruise Ship‡
Positive342
† Numbers closed out at 4 p.m. the day before reporting.
(Does not include the case of community spread from Solano Co. CA)
 

pops88

Girls with Guns Member
Trump Furious With CDC For 'Spooking' Market: WaPo

Wed, 02/26/2020 - 11:55

President Trump's penchant for viewing the stock market's performance as a barometer of his presidency's success is widely known to the public by now. So the fact that Trump has been extremely agitated by goings-on back home during his trip to India this week is hardly a surprise.



Usually, we don't give much credence to the Washington Post's inside-baseball stories purporting to offer a 'peak behind the curtain' while creating a venue for vindictive officials to exact their revenge by anonymously trashing the president or rivals within the administration.

But today, WaPo's account basically confirms what we suspect has been unfolding behind the scenes, with the president turning on yet another federal agency and blaming it for spooking the markets. In the past, Trump has (either publicly or privately) blamed Democrats, Treasury Secretary Mnuchin, Labor Secretary Wilbur Ross, Boeing and - of course - Jay Powell for the market selloffs.

Now, we can add the CDC to that list.

The paragraph below is basically the heart of WaPo's story, describing President Trump's impotent fury at helplessly observing the selloff from afar.

Specifically, Trump was furious at the CDC for its press conference on Tuesday which appeared to rattle the market and cemented the selloff for a fourth day. The No. 1 rule for successful propaganda is to make sure your source still appears credible to the unengaged reader or viewer. When one insists on pushing a narrative that is completely divergent from the lived experience of millions, credibility can be damaged.


Just like the State Department's decision to bring back 14 infected Americans during their evacuation of the 'Diamond Princess', the administration's approach has left it open to criticism - at least, according to the Washington Post.

At least one analyst appeared to agree.

On CNBC, guests complained that the administration's message sounded muddled and confused yesterday, which certainly didn't help boost the market's confidence. Fortunately for investors, the administration has refined its message, as Kudlow and others insisted that Trump's warnings represent "where we are now", while the CDC is focused on staving off the worst-case scenario.

A snippet from Kudlow's appearance on CNBC yesterday is one example:

The White House also blamed Democrats and accused them of trying to deliberately trying to scare markets in an effort to sabotage Trump.



And let's not forget the Dems media allies.

President Trump initially dismissed the virus during his trip to Davos in January, and has issued a string of optimistic tweets this week, including encouraging investors to 'buy the f--king dip' on Monday. Unfortunately, those who took the president's advice probably got smoked.

With more than 50 cases confirmed in the US and the CDC warning about imminent community outbreaks, Trump's words can sound jarring. But remember: The better prepared everyone is, the less likely the virus will spread. And nothing inspires this type of behavior quite as effectively as genuine paranoia.

The only problem is, it will take time before we know for sure whether the Trump Administration's travel restrictions were effective.

Trump will address the outbreak at 6 pm ET. Watch it live here.

Meanwhile, before we go, we'd like to point out another angle that was unsurprisingly overlooked by WaPo: the CDC's Dr. Nancy Messonnier is the sister of the former Deputy Attorney General Rod Rosenstein, the one who appointed Special Counsel Robert Mueller and was eventually fired by President Trump following a tense overall tenure.

Is it possible she could be part of the resistance?

Also, as we've pointed out previously, the CDC's diagnostic tests have malfunctioned and only a few states and local health agencies have any tests on hand.

Is Trump being set up?

Not to turn this into a Q thread, but the picture I see is a present being wrapped up for a grand celebration...and she's part of Haman's group that will hang on their own gallows. Cake, sparklers, confetti...it will be grand.
 

garnetgirl

Veteran Member
I put this on another thread, too, but it's just a positive bit of local information that pertains to the big picture ~

I think there are a lot more preparations going on behind the scenes than we realize. A friend of mine who works in the small rural health department in my town told me yesterday that they had been attending pandemic preparation meetings and getting information for the last two weeks. Yesterday, they were all fitted for respirators. I was very encouraged to hear this.

garnetgirl
 

marsh

On TB every waking moment
BIG BOOKMARK!


If the coronavirus hits America, who’s responsible for protecting you?

What the response to a Covid-19 outbreak in the US could look like.
By Brian Resnick@B_resnickbrian@vox.com Updated Feb 26, 2020, 6:50pm EST

The outbreak of the coronavirus — and Covid-19, the disease it causes — in mainland China has provoked a response the likes of which the world has never seen. Hundreds of millions of people in the country have had their travel restricted; many have not even been allowed to leave their homes. All of this is aided by the vast Chinese surveillance state.

Meanwhile, though the number of new cases in China dropped to 406 on Wednesday, bringing the total to 78,000, China is ramping up capacity to treat tens of thousands of sick people, with new hospitals going up nearly overnight. Many people still haven’t returned to work, though some of the restrictions are being eased.

Draconian restrictions on movement and the intensive tracking of people potentially exposed to the virus are just some of the ways China — a centralized, authoritarian state — has responded to its outbreak.

What would have happened if the outbreak had started in the US — or if it comes here next?

The number of confirmed cases in the US is small: just 14, and 12 are related to travel. An additional 45 people who were sickened with Covid-19 abroad have returned to the US for treatment. On Tuesday, the Centers for Disease Control and Prevention shifted its message on the likelihood of the coronavirus spreading in the United States. “Ultimately we expect we will see community spread in this country,” Nancy Messonnier, director of the CDC’s National Center for Immunization and Respiratory Diseases, told reporters in a press call. She said it’s a matter of “when,” not “if,” and that “disruption to everyday life might be severe.”

There’s still a lot we don’t about the virus. It’s a novel, fast-spreading disease to which people have no immunity. So far, no vaccines or drugs to treat it exist, though both are being developed. That said, many of the cases of Covid-19 are mild, as Vox’s Julia Belluz reports. The fatality rate — which remains an early estimate that could change — is hovering around 2 percent. A virus of these parameters could spread very quickly.

While there’s much we don’t know about how this could play out with regard to how many people will get sick and how sick they’ll get, what we do know is the United States has dealt with outbreaks — polio, tuberculosis, and H1N1 flu, for starters — before, and many health officials have been anticipating a new one. There are lots of professionals on the federal and local levels who stand ready to try to stymie the spread of coronavirus in the United States.

That’s not to say our system is perfect, or even necessarily prepared for this incoming novel virus. But it’s worth thinking through what responses are possible in the United States and how they might become politicized. There are a few really important things to know.

The biggest one: Public health is a power that’s largely left up to the states, which introduces flexibility into our system. But it also introduces inconsistencies, local politics, and laws, with varying protections for civil liberties. The biggest question remains: Can our health care infrastructure handle an influx of thousands of new patients?

Public health is largely up to the states

The first question to ask about outbreak response in the United States: Who is in charge?

You may think “the White House,” or some arm of the federal government. But per the 10th Amendment of the US Constitution, public health is not a power specifically given to the federal government, and so it rests mainly with the states, as well as large cities with strong public health departments, like New York City.

“It’s important to remember that public health is actually a police power that is delegated to the states,” says Rebecca Katz, director of the Center for Global Health Science and Security at Georgetown.

GettyImages_1208657595.jpg
This may be good news if you’re nervous about the Trump administration’s preparedness for a significant outbreak. The federal government does have some powers, including the right to quarantine travelers coming from abroad (the CDC recently issued its first mandated quarantine on travelers in 50 years due to Covid-19), and to impose travel restrictions. If things get really bad, the federal government “can basically federalize state response if there’s a failure of local control,” says Tom Frieden, former director of the CDC and former New York City health commissioner. But local control comes first.

The federal government maintains the CDC, the premier disease-tracking and prevention research agency in the world, whose guidance is essential during an outbreak. The agency also maintains a strategic stockpile of medical supplies like respirators to deploy in a wide-ranging pandemic.

The administration could also appoint a person (like a Covid-19 “czar”) to oversee coordination between the many departments of the federal government (Health and Human Services, Agriculture, and others) to aid the response. On Wednesday, President Donald Trump did that, saying that Vice President Mike Pence will be in charge of the federal response.

“There used to be a White House office in charge of pandemic prevention and response,” says Ron Klain, who led the response to the 2014 Ebola epidemic under the Obama administration. “President Trump abolished the office in 2018.”

How local governments could intervene in an outbreak

Cities and states hold most of the power to act during an outbreak. What could they do?

“There are pros and cons to the decentralized way we do public health in the US,” Frieden says. “There’s enough autonomy so that New York City doesn’t need permission from New York state or the CDC or the federal government to announce an outbreak and begin aggressive control measures.”

How aggressive could it get? State governments, as well as some large cities, have the power to order quarantines, or the practice of isolating people who may have been exposed to a virus in order to prevent them from spreading the illness before they start experiencing symptoms.

The power is not only to order quarantines, but also to enforce them. “Public health is actually a police power that is delegated to the states,” Katz says. “You could end up with someone coming to your door, and saying, ‘You’ve been exposed, and you’re either coming with me, or you have to stay in your house.’”
AP_20055432911306.jpg

They could force you to stay at home or detain you in a facility. “There are still some places in the country where they may put someone with active TB [tuberculosis] in a jail cell,” Katz added, “because it might be the only place available for negative pressure containment [an air-purification scheme].”

To be clear, that’s an extreme scenario. Katz says these detainment powers are rarely, if ever, used. To start, a quarantine order would probably be voluntary, and possibly limited to people who know for sure that they have had direct contact with an infected person. (Katz suggests that if it comes to it, think of quarantine as jury duty — an annoying civic duty you just have to endure.)
Health policy experts also debate the effectiveness of using mass quarantines and shutting down cities to stop or prevent the spread of an outbreak. Generally, the focus is on isolating patients who are actually sick and quarantining contacts who may have been exposed. But that’s not to say a local government wouldn’t turn to quarantines or travel restrictions, despite public health experts advising against them.

During an outbreak, local authorities would likely take their guidance from the CDC and the federal government. But it would be up to these local authorities to enact the “disruption to everyday life” that Messonnier mentioned in the press call.

Quarantine is not the only option for slowing an outbreak. Depending on how the virus spreads, it could be extremely hard to find people who have been exposed and put them in quarantine.

Other measures can be put into place, such as postponing or canceling mass gatherings like sporting events, concerts, or religious gatherings. It could mean closing schools (any local school board could decide to do this independently) or encouraging telework. The CDC calls such measures “social distancing,” designed to slow the spread of a contagious disease. (Other good practices during any outbreak: Stay home if you’re sick, cover your coughs and sneezes, and wash your hands.)

The CDC’s Messonnier wants people to prepare for the possibility of these social-distancing measures and figure out how they might live and work around them. “Think about what you’d do for child care if schools or daycares are closed,” she said. “Is teleworking an option for you? Does your health care provider offer a telemedicine option? All of these questions can help you be better prepared for what might happen.” (The CDC maintains a guide for families to prepare for pandemic flu. Some of the recommendations could also apply to a respiratory illness like Covid-19.)

What’s not going to happen in the US: the wholesale lockdown of a city, like what has occurred in Wuhan, China, where the virus originated.

“It would be impossible to shut down a major city in United States,” Klain says. “You couldn’t feed the people in the city without things coming in and out. You couldn’t remove the garbage. You couldn’t run the health care system. In the end, if you tried to shut down a major city in the United States, more people would die from the impact on the hospitals in that city ... than you would save by slowing the spread of coronavirus.”

The cons of this system

A pro of our decentralized public health system is that individual communities can be nimble and decide what’s best in dealing with an outbreak. A con is that we end up with a potential patchwork of responses. Viruses don’t care about state or city boundaries, and people routinely travel between them. Overall, that could make it harder to control the spread of an infection.

Katz has conducted research into the variety of quarantine laws that exist across states. “Most of these laws are really old and haven’t been updated,” she says. “A lot of the state-level regulations have not been updated since the civil rights and individual rights laws of the ‘60s and ‘70s went into effect.” Some laws don’t provide protections such as a right to legal counsel when being quarantined. Very few states — only 20 percent — have provisions to keep people from being fired from missing work during a quarantine.

The upshot is this: Because many states haven’t bothered to revise these laws, they haven’t thought through what a modern-day quarantine should look like or what rights need to be respected.

Katz’s co-authored 2018 paper on this sums it up starkly:
Fewer than half of state laws even include right to counsel during a quarantine, and many fewer have written protections for being able to choose a medical provider or receive compensation for damages that may occur. While half of the states have granted explicit police powers to enforce public health actions during a quarantine, half do not. And only 20% provide any employment protection for individuals forced to stay away from work for the betterment of society. More worrisome, less than half of the states have language in their laws and regulations related to providing safe and humane quarantines.
“We believe the variation between states and the inclusion of curious rules creates an environment across the country that will result in unease, confusion, and possibly civil unrest if large-scale quarantines are ever required,” the paper concluded.

The patchwork also introduces politics into the mix. Governors, mayors, school boards, and other local officials are politicians, who we know don’t always heed the best available advice of scientific experts. A few weeks ago, during a House hearing on the emerging coronavirus outbreak, Johns Hopkins University infectious disease expert Jennifer Nuzzo testified that international travel bans during outbreaks are unproductive and ineffective. Congressman Brian Mast (R-FL) said her testimony “does not pass the test of common sense.”

Political responses to the outbreak may be wide-ranging. Some may fear that acting will hurt their local economy, while others may overreact. In 2014, a teacher in Maine was placed on leave because he had traveled to Dallas, where an Ebola patient died in a hospital (the teacher had not visited the hospital). During the Ebola outbreak, then-New Jersey Gov. Chris Christie forced a nurse who had treated Ebola patients in Africa into quarantine. She never exhibited symptoms of the disease, and experts concluded she posed no risk. But the governor held her in isolation anyway. The nurse ended up suing the state, arguing her rights had been infringed upon.

Already, we have seen ways in which local politics can influence the US response to Covid-19. The city of Cosa Mesa, California, has gone to court trying to block federally quarantined patients from going to a facility there. The Trump administration scrapped plans to send quarantined people from the Diamond Princess cruise ship to a facility in Alabama after local outcry.

Another fear is that Trump will undermine the advice and messaging of the CDC for political or personal reasons, similar to the “SharpieGate” incident in which Trump displayed an altered version of a National Oceanic and Atmospheric Administration hurricane forecast map for the press. Trump had previously erroneously tweeted that Alabama had been in the path of Hurricane Dorian, and the altered map seemed intended to make the president look like he was correct all along.

The White House is getting moving on a coronavirus response, requesting Congress for $1.25 billion in emergency funding to prepare (though they request the money be sourced from funds allocated toward work on the Ebola virus). Trump, so far, has been downplaying the risk of the coronavirus taking hold here, but is reportedly “furious” about how the news of the disease is impacting the US stock market.

Are hospitals ready?

The scariest what-if to think through is this: What if a disease like Covid-19 does start to spread widely here, sending thousands or more to hospitals across the country? Another worry is that transmission would likely begin in a big, urban environment with international travel hubs. Could our institutions handle that?
“No,” Klain says bluntly. “That’s one of the most dangerous things about this. It could overwhelm a local health care system. We don’t have extra hospitals just sitting around with doctors and nurses and beds with no patients in them. That’s not the way our health care system works, right? Underperforming hospitals are shut down. Generally, hospitals run pretty full. What if all of a sudden 10,000 sick people needed hospitalization in a major city? There’s no 10,000 extra beds sitting around someplace.”

(It bears mentioning another concern: This is the American health care system, where sick people are known to avoid care due to fears of high medical bills.)
We’d likely have to build tent hospitals to triage patients, and possibly cancel elective surgeries to free up beds in existing facilities.

“You’ll find patients backed up in the emergency room, you will find patients on gurneys because there aren’t enough beds,” says William Schaffner, a professor of preventive medicine and infectious diseases at the Vanderbilt University School of Medicine. He says all hospitals will have a pandemic preparedness plan, which is often rehearsed. But even the best plans have flaws.

During the 2009 H1N1 flu pandemic, Schaffner says that caregivers at Vanderbilt’s emergency pediatric department were getting fatigued. “We didn’t have kind of a team on the bench who were emergency pediatric certified to go in. So we got volunteers from the rest of the pediatric physician staff,” he said. “These staff members had to quickly be trained for the emergency room.”
Diseases are chaotic by nature. Outbreaks test the system and will reveal its flaws. Just how unprepared is the US medical system for a big outbreak? Hopefully, we won’t have to find out.
 

Swamp Wallaby

International Observer
Israel confirms third coronavirus case

Israel's health ministry said a man who returned from travel in Italy has tested positive for coronavirus.

The man returned from Italy four days ago and tested positive after developing symptoms, the ministry said.

It is the country's third coronavirus case.


Greece reports two new coronavirus cases

Greece has reported two new cases of coronavirus in the past 24 hours, bringing the total number of confirmed cases to three.

The health ministry said one of the cases concerned a relative of a 38-year-old woman in the northern town of Thessaloniki, the first confirmed case reported in Greece.

The woman had recently returned from Milan in northern Italy.


Swiss confirm three new coronavirus cases

The number of confirmed coronavirus cases in Switzerland has risen to four, the country's health authority said.

In the western canton of Geneva one person was tested positive for the virus while it was also confirmed in a couple in the southeastern Alpine canton of Grisons, it added.

"All three patients are isolated in the hospital. Their condition is good," the Federal Office of Public Health said.


Iranian official confirmed infected with coronavirus

Mojtaba Zonnour, head of Iranian parliament's National Security and Foreign Relations Commission says he is infected with COVID-19.

Zonnour, who is also a deputy from the country's virus-hit Qom city, said in a video message that he is currently in quarantine.


Crew leaves Japan virus-hit ship for new quarantine

Crew members from a coronavirus-stricken cruise ship off Japan began leaving the vessel for a new quarantine on-shore after passengers left the boat, the government said.

"Today, 240 crew members are leaving the ship and this disembarking operation will continue for a couple of days," a health ministry official told AFP news agency.

Those leaving the boat will be placed in medical observation for 14 days at government-designated dormitories before being allowed to leave Japan, they said.


Iran infection cases reach 245, deaths 26

Iran's health ministry spokesman says the new coronavirus has killed 26 people amid 245 confirmed cases in the country.

 

marsh

On TB every waking moment

Korean Air Flight Attendant Working LAX Flights Diagnosed With Coronavirus
February 26, 2020 at 8:14 am

LOS ANGELES (CBSLA) – A flight attendant for Korean Air who worked several flights out of Los Angeles International Airport has been diagnosed with coronavirus.

The 24-year-old was diagnosed Tuesday in southern Seoul, according to the Korea Joongang Daily newspaper.

The flight attendant had worked flights between LAX and Seoul–Incheon International Airport on Feb. 19 and 20, according to South Korean media outlets.

The woman also serviced a flight from Tel Aviv, Israel, to Seoul on Feb. 15, South Korea’s Center for Disease Control said. She may have contracted the virus from a South Korean church group who were on a pilgrimage to Israel, the Yonghap News Agency reports.

So far, 30 members of that church group have been diagnosed with coronavirus, according to South Korean health authorities.

Korean Air has closed its operations center at Incheon Airport in order to disinfect the area.

Meanwhile, a 23-year-old U.S. soldier stationed at Camp Carroll in South Korea has also tested positive for coronavirus, U.S. Forces Korea (USFK) confirmed in a statement Tuesday.

He has been quarantined off-base.

“Korea Centers for Disease Control and Prevention and USFK health professionals are actively conducting contact tracing to determine whether any others may have been exposed,” USFK said.

On Tuesday, concerns over the spread of the coronavirus forced organizers to postpone the Korea Times Music Festival at the Hollywood Bowl.

According to the Yonghap News Agency, South Korea has 1,261 confirmed coronavirus cases, including 12 deaths.

According to the U.S. Centers for Disease Control and Prevention, the novel coronavirus, COVID-19, is spread from person-to-person through close contact, usually within 6 feet, and mainly via respiratory droplets when an infected person coughs or sneezes. Symptoms include fever, cough and shortness of breath. People are likely most contagious when they are most symptomatic.
 

marsh

On TB every waking moment
Riverside County Resident Evacuated From Cruise Ship In Japan Tests Positive For Coronavirus
February 25, 2020 at 10:22 pm

RIVERSIDE (CBSLA) — A Riverside County resident tested positive for the coronavirus after being evacuated from a Diamond Princess cruise ship quarantined off the coast of Japan, county health officials confirmed Tuesday.
The unidentified patient was being treated in Northern California and “is expected to fully recover,” according to health officials.


A crew member wearing a face mask walks on the deck of the Diamond Princess cruise ship at Daikoku pier cruise terminal in Yokohama on February 24, 2020.
The infected person was being closely monitored and there was no indication of local exposures in the county, Riverside County’s public health officer Cameron Kaiser reported.

In South Korea the first U.S. military soldier tested positive for the virus, the Associated Press announced. According to the U.S. military, the soldier was in self-quarantine at his off-base residence.

Orange County locals and county leaders continued Tuesday to push back against a state and federal plan to transfer an unknown number of patients infected with the coronavirus to Costa Mesa’s Fairview Developmental Center.
A small group of protesters gathered to keep the patients from arriving at the state-owned site which is located within a mile of thousands of apartments and houses, major retail centers, the Costa Mesa Golf and Country Club, the Orange County Fairgrounds, Vanguard University, the Costa Mesa police department, and City Hall.

“The truth is we don’t know enough about this virus after being in here they can be transferred to hospitals in the area,” said one protester.

On Sunday, the U.S. Department of Health and Human Services said in a statement that Naval Base Ventura County Point Mugu may receive American travelers coming through LAX who would be quarantined to be monitored for symptoms of coronavirus.

The coronavirus is not currently spreading in U.S. communities, according to the statement. Both the CDC and HHS have said that person-to-person spread of coronavirus in the U.S. has only been seen among close contacts of returned travelers from Wuhan.

The coronavirus, known as COVID-19, originated in China and has killed more than 2,700 people. More than 80 thousand cases have been reported, including 57 in the U.S.

As of Tuesday, there were no confirmed cases of the virus in Riverside County.
 

marsh

On TB every waking moment
Biochem Biophys Res Commun. 2020 Feb 17. pii: S0006-291X(20)30339-9. doi: 10.1016/j.bbrc.2020.02.071. [Epub ahead of print]
Structure analysis of the receptor binding of 2019-nCoV.
Chen Y1, Guo Y1, Pan Y2, Zhao ZJ3.
Author information

Abstract

2019-nCoV is a newly identified coronavirus with high similarity to SARS-CoV. We performed a structural analysis of the receptor binding domain (RBD) of spike glycoprotein responsible for entry of coronaviruses into host cells. The RBDs from the two viruses share 72% identity in amino acid sequences, and molecular simulation reveals highly similar ternary structures. However, 2019-nCoV has a distinct loop with flexible glycyl residues replacing rigid prolyl residues in SARS-CoV. Molecular modeling revealed that 2019-nCoV RBD has a stronger interaction with angiotensin converting enzyme 2 (ACE2). A unique phenylalanine F486 in the flexible loop likely plays a major role because its penetration into a deep hydrophobic pocket in ACE2. ACE2 is widely expressed with conserved primary structures throughout the animal kingdom from fish, amphibians, reptiles, birds, to mammals. Structural analysis suggests that ACE2 from these animals can potentially bind RBD of 2019-nCoV, making them all possible natural hosts for the virus. 2019-nCoV is thought to be transmitted through respiratory droplets. However, since ACE2 is predominantly expressed in intestines, testis, and kidney, fecal-oral and other routes of transmission are also possible. Finally, antibodies and small molecular inhibitors that can block the interaction of ACE2 with RBD should be developed to combat the virus.
 

Trivium Pursuit

Has No Life - Lives on TB
Top